Tumor escape from killing: Role of killer inhibitory receptors and acquisition of tumor resistance to cell death

Chouaı̈b, Salem; Thiery, Jérôme; Gati, Asma; Guerra, Nadia; Behi, Mohamed El; Dorothée, Guillaume; Mami‐Chouaib, Fathia; Bellet, Dominique; Caignard, Anne

doi:10.1034/j.1399-0039.2002.600401.x

Cited by 30 publications

(15 citation statements)

References 48 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent report (72) demonstrates that KIR-incompatible allogeneic NK cells have superior antitumor effects against fresh tumor cells isolated from different solid cancers, as well as against MEL and RCC established tumor cell lines (73). Interactions between solid tumor cells and the microenvironment in vivo create a context that promotes tumor growth, selection, and protection from immune attack, suggesting that the tridimensional architecture of solid cancer lesions is likely one of the tumor mechanisms to escape immunosurveillance (70). To this regard, another important mechanism to control NK cell activity is their ability to traffic to tumor sites.…”

Section: Nk Cell-based Immunotherapeutic Strategies Against Cancermentioning

confidence: 99%

NK Cells and Cancer

Zamai

Ponti

Mirandola

et al. 2007

The Journal of Immunology

261

199

View full text Add to dashboard Cite

In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on the recent acknowledgments on the efficacy of NK cells after cytokine and mAb administration in cancer therapy. Since efficacy of NK cell-based immunotherapy has been proven in KIR-mismatch regimens or in TRAIL-dependent apoptosis, the ability to manipulate the balance of activating and inhibitory receptors on NK cells and of their cognate ligands, as well as the sensitivity of tumor cells to apoptosis, opens new perspectives for NK cell-based immunotherapy.

show abstract

Section: Nk Cell-based Immunotherapeutic Strategies Against Cancermentioning

confidence: 99%

NK Cells and Cancer

Zamai

Ponti

Mirandola

et al. 2007

The Journal of Immunology

261

199

View full text Add to dashboard Cite

show abstract

“…It is well established that cell proliferation reflects the interplay of cell survival and cell death pathways and that the resistance of tumor cells to cytotoxic treatments involves multiple mechanisms protecting cells from apoptosis (28). Therefore, understanding the molecular basis of the survival pathways and the ways they intersect with the apoptotic cascade and identifying agents that can bypass these signals will likely be necessary for the development of effective immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of a Tumor Cell Susceptibility to Autologous CTL Killing by Restoration of Wild-Type p53 Function

Thiery

Dorothée

Haddada

et al. 2003

The Journal of Immunology

View full text Add to dashboard Cite

Inactivation of p53 has been implicated in many types of tumors particularly in non-small cell lung carcinoma, one of the most common cancers in which p53 mutation has been frequently identified. The aim of this study was to investigate the influence of p53 status on the regulation of tumor susceptibility to specific CTL-mediated cell death. For this purpose, we used a cytotoxic T lymphocyte clone, Heu127, able to lyse the human autologous lung carcinoma cell line, IGR-Heu, in a HLA-A2-restricted manner. Direct genomic DNA sequencing revealed that IGR-Heu expresses a mutated p53 at codon 132 of the exon 5 which results in the loss of p53 capacity to induce the expression of the p53-regulated gene product p21waf/CIP1. Initial experiments demonstrated that IGR-Heu was resistant to Fas, TNF, and TRAIL apoptotic pathways. This correlated with the lack of p55 TNFRI, Fas, DR4, and DR5 expression. The effect of wild-type (wt) p53 restoration on the sensitization of IGR-Heu to autologous CTL clone lysis was investigated following infection of the tumor cell line with a recombinant adenovirus encoding the wt p53 (Adwtp53). We demonstrate that the restoration of wt p53 expression and function resulted in a significant potentiation of target cell susceptibility to CTL-mediated lysis. The wt p53-induced optimization of tumor cell killing by specific CTL involves at least in part Fas-mediated pathway via induction of CD95 expression by tumor cells but does not appear to interfere with granzyme B cytotoxic pathway.

show abstract

“…37 An interesting example of exogenous form of tumour escape and its link with the processes of the apoptosis may be the autocrinic secretion of Fas L, which protects the tumour cells from the Fas-mediated apoptosis (mediated by the cytotoxic lymphocytes). 38,39 In the cases of melanomas of the vascular coat of the eye, the tumour cells exhibit Fas-receptor, but they are insensitive not only with respect to the T-cell mediated apoptosis, but also to the apoptosis mediated by the Fas-specific antibodies with agony provoking effect.…”

Section: Connections Between the Different Forms Of Tumour Escape?mentioning

confidence: 99%

“…2,23,39 By analogy with the KIR receptors, they also possess both activating and inhibiting function in the transmission of the respective signals. Five types of Lectin-Like-Receptors have been discovered in the human body, expressed as hetero-or homodimers.…”

Section: Kir-and Lectin-like Receptors and Tumour Escapementioning

confidence: 99%

See 1 more Smart Citation

Dissecting the pathways of tumour escape: " question of life and death?"

Tchernev

Nenoff

2010

An. Bras. Dermatol.

View full text Add to dashboard Cite

Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction pathways within the tumour cells and between these and the immune system. The article focuses attention on the evolution of the melanocytic naevi in the direction of a dysplastic or tumour cell. The determination of single molecules as prognostic parameters within cancer genesis seems to be problematic. New hopes are being placed on the treatment with TW-37, ABT-737 and TAT-Bim, which, to an extent, are able to support the programmed cell death. The clinical importance of these innovative therapies remains to be seen and should therefore, be viewed with considerable criticism. Keywords: Apoptosis; bcl-2-Associated X Protein; Cell cycle; HLA antigens Resumo: Caminhos apoptóticos estão fornecendo importantes mecanismos de salvaguarda na proteção contra o câncer através da eliminação de células alteradas e freqüentemente nocivas. Os distúrbios de proliferação, diferenciação e apoptose celular são também encontrados nos caminhos específicos sinal-transdução dentro das células tumor e entre essas células e o sistema imunitário. O artigo foca na evolução da verruga conhecida como melanocytic naevi em direção a uma célula displasica ou célula tumor. A determinação de moléculas isoladas como parâmetros de prognóstico dentro da gênesis do câncer parece problemática. Novas esperanças estão sendo colocadas no tratamento com TW-37, ABT-737 e TAT-Bim, os quais, até certo ponto, são aptos a apoiar a morte celular programada (PCD). A importância clínica dessas terapias inovadoras permanece ainda a ser vista e devem, por essa razão, serem olhadas com considerável juízo crítico. Palavras-chave: Apoptose; Antígenos HLA; Ciclo celular; Proteína X associada a bel-2 Aprovado pelo Conselho Editorial e aceito para publicação em 15.12.2009.

show abstract

Tumor escape from killing: Role of killer inhibitory receptors and acquisition of tumor resistance to cell death

Cited by 30 publications

References 48 publications

NK Cells and Cancer

NK Cells and Cancer

Potentiation of a Tumor Cell Susceptibility to Autologous CTL Killing by Restoration of Wild-Type p53 Function

Dissecting the pathways of tumour escape: " question of life and death?"

Contact Info

Product

Resources

About