2001
DOI: 10.1016/s0360-3016(01)01523-1
|View full text |Cite
|
Sign up to set email alerts
|

Tumor hypoxia, p53, and prognosis in cervical cancers

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
27
0
1

Year Published

2002
2002
2010
2010

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 60 publications
(29 citation statements)
references
References 31 publications
1
27
0
1
Order By: Relevance
“…This was not expected based on a similar but smaller study in NSCLC, where high buccal cell adducts were associated with better survival. 13 However, other studies in the literature are conflicting concerning the relationship between adduct levels and outcome. Inconsistencies may be related to the range of different tumor and cell types studied, different chemotherapy schedules, and different measurement methods and assay times.…”
Section: Discussionmentioning
confidence: 99%
“…This was not expected based on a similar but smaller study in NSCLC, where high buccal cell adducts were associated with better survival. 13 However, other studies in the literature are conflicting concerning the relationship between adduct levels and outcome. Inconsistencies may be related to the range of different tumor and cell types studied, different chemotherapy schedules, and different measurement methods and assay times.…”
Section: Discussionmentioning
confidence: 99%
“…Although the present investigation is limited due to its retrospective character these findings may stimulate further research into the association between anaemia and outcome of chemotherapy. Interactions may be possible on several levels such as, e.g., increased bloodflow and drug delivery to the tumour in less anaemic patients or higher effectiveness of radical generating agents in the presence of better oxygen supply as postulated for radiotherapy (Haensgen et al, 2001). Since anaemia is a major problem in dose intensive therapy in the young patient population with germ cell cancer the effects of erythropoietic growth factors on the frequency of transfusions, quality of life and potentially also on overall response to chemotherapy should be further studied.…”
Section: Discussionmentioning
confidence: 99%
“…Squamous cell carcinomas of the uterine cervix, characterized by pronounced hypoxia (Sundfor et al, 1998) and low apoptotic index (Hockel et al, 1999), showed a high probability for lymphatic spread and recurrence, despite adjuvant treatment with radiation or chemotherapy in addition to radical surgery (Hockel et al, 1999). Also, in cervix carcinomas a significant correlation between hypoxia and functionally impaired p53 was demonstrated (Haensgen et al, 2001). p53 status and hypoxia had no independent prognostic impact on overall survival, but the combination of these two parameters was a significant prognostic factor (Haensgen et al, 2001).…”
Section: Molecular Effectsmentioning
confidence: 95%
“…Also, in cervix carcinomas a significant correlation between hypoxia and functionally impaired p53 was demonstrated (Haensgen et al, 2001). p53 status and hypoxia had no independent prognostic impact on overall survival, but the combination of these two parameters was a significant prognostic factor (Haensgen et al, 2001). On the other hand, in patients with primary soft tissue sarcoma, no association was found between median pO 2 and p53 status (Nordsmark et al, 2001a).…”
Section: Molecular Effectsmentioning
confidence: 95%