Tumor Inflammatory Microenvironment in EMT and Metastasis

Yuan, Tingting; Wu, Yadi; Zhou, Peter L.

doi:10.5772/32219

Cited by 5 publications

(5 citation statements)

References 151 publications

(162 reference statements)

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“…EMT can also be triggered by the signals induced by growth factor (FGF, EGF, HGF, VEGF) receptors involved in activation of the RAS-ERK1/2 or PI3K-Akt pathways. The EMT process is also strongly influenced by stimuli derived from tumour microenvironment, such as inflammation, hypoxia and metabolic or oncogenic stress (Kalluri and Weinberg 2009 ; Yuan et al 2012 ). The existence of a positive feedback loop between pro-inflammatory microenvironment and EMT has been shown in several experiments (Mantovani et al 2008 ; López-Novoa and Nieto 2009 ).…”

Section: Micrornasmentioning

confidence: 99%

MicroRNAs in regulation of triple-negative breast cancer progression

Piasecka

Braun

Kordek

et al. 2018

J Cancer Res Clin Oncol

147

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PurposeDysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy.MethodsPubMed and Medline databases were systematically searched for the relevant literature. 121 articles have been selected and thoroughly analysed.ResultsSeveral miRNAs associated with EMT/CSC and invasion were identified as significantly (1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC. Dysregulation of miR-10b, miR-21, miR-29, miR-145, miR-200 family, miR-203, miR-221/222 was reported of prognostic value in TNBC patients.ConclusionAvailable data suggest that specific microRNA clusters might play an important role in biology of TNBC, understanding of which should assist disease prognostication and therapy.

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Section: Micrornasmentioning

confidence: 99%

MicroRNAs in regulation of triple-negative breast cancer progression

Piasecka

Braun

Kordek

et al. 2018

J Cancer Res Clin Oncol

147

View full text Add to dashboard Cite

show abstract

“…There has been substantial clinical and experimental evidence that TAMs orchestrate all the stages of tumor progression. [ 5 11 23 24 ] M2 TAMs produce many immunomodulatory molecules including checkpoint inhibitors, and factors promoting angiogenesis[ 25 ] and tissue reconstruction, thus exerting trophic effects that exerts stromal angiogenesis, matrix breakdown[ 7 21 ] due to cleavage of E-cadherin-β-catenin complex and consecutive activation of Wnt-β-catenin pathway which is the main inducer of EMT[ 11 26 27 ] leading to tumor progression.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] Approximately 90% of cancer-related death is caused by metastasis. [ 5 ] Despite advances in the surgical, chemotherapy and radiotherapy treatment options, the 5-year survival rate has not been improved significantly in the past few years. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of density of tumor-associated macrophages using CD163 in histological grades of oral squamous cell carcinoma, an immunohistochemical study

Chaudhari

Prakash

Pradeep

et al. 2020

J Oral Maxillofac Pathol

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“…TME has a close connection with tumor progression and metastasis [7]. It has been demonstrated in ccRCC that there is an intimate connection between immune cell infiltration in TME and tumor progression and its clinical outcome [8].…”

Section: Introductionmentioning

confidence: 99%

Development of an Immune Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Tumor Microenvironment

Wang

Song

et al. 2023

Horm Metab Res

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Immune infiltration remains at a high level in clear cell renal cell carcinoma (ccRCC). It has been confirmed that immune cell infiltration in tumor microenvironment (TME) is intimately bound up with the progression and the clinical outcome of ccRCC. The prognostic model, developed based on different immune subtypes of ccRCC, has a predictive value in patients’ prognosis. RNA sequencing data, somatic mutation data of ccRCC and clinical information were acquired from the cancer genome atlas (TCGA) database. The key immune-related genes (IRGs) were selected and by univariate Cox, LASSO, and multivariate Cox regression analyses. Then the ccRCC prognostic model was developed. The applicability of this model was verified in the independent dataset GSE29609. Thirteen IRGs including CCL7, ATP6V1C2, ATP2B3, ELAVL2, SLC22A8, DPP6, EREG, SERPINA7, PAGE2B, ADCYAP1, ZNF560, MUC20, and ANKRD30A were finally selected and a 13-IRGs prognostic model was developed. Survival analysis demonstrated that when compared with the low-risk group, patients in the high-risk group had a lower overall survival (p<0.05). AUC values based on the 13-IRGs prognostic model used to predict 3- and 5-year survival of ccRCC patients were greater than 0.70. And risk score was an independent prognostic factor (p<0.001). In addition, nomogram could accurately predict ccRCC patient’s prognosis. This 13-IRGs model can effectively evaluate the prognosis of ccRCC patients, and also provide guidance for the treatment and prognosis of ccRCC patients.

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Tumor Inflammatory Microenvironment in EMT and Metastasis

Cited by 5 publications

References 151 publications

MicroRNAs in regulation of triple-negative breast cancer progression

MicroRNAs in regulation of triple-negative breast cancer progression

Evaluation of density of tumor-associated macrophages using CD163 in histological grades of oral squamous cell carcinoma, an immunohistochemical study

Development of an Immune Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Tumor Microenvironment

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