Tumor Localizing Agents VI

Radioiodinated Small Molecules and Their Applications

“…[93,94] Appelgren [95] showed, by autoradiography and radioassay techniques,that 14C-labeled cholesterol localized in the adrenal cortex of mice to a greater extent than any other of the steroid analogues. [99] Counsell and associates, [100] and Lieberman and associates [101] as a scanning agent to visualize adrenal glands. Radioiodinated cholesterol is used as an adrenal scanning agent ( Fig.…”

Synthesis and evaluation of radioiodinated cholesteryl ethers as lipoprotein probes

“…Because of our interest in tracers for diagnostic imaging, our attention has focused on lipid analogues labeled with 7-emitting nuclides such as the various radioisotopes of iodine, namely 1231, 126I, and 131I (2). Radioiodinated lipids, such as [131I]19-iodocholesterol, have been found to be useful not only as diagnostic agents in nuclear medicine (3,4) but also as radiolabeled probes in biochemical studies (5). Radioiodinated 7-emitting probes offer the advantage of being more readily counted than tritium or carbon-14-labeled compounds and frequently their synthesis is more readily accomplished.…”

“…7.54 (s, 1 H, arom H2), 7.5 (d, 1 H, arom H4), 7.13 (d, 1 H, arom H6), 7.0 (t, 1 H, arom H5), 5.35 (d, 1 H, 6 vinyl H), 3.45 (t, 2 H, CH20), 3.12 (m, 1 , a-H), 2.53 (t, 2 H, PhCH2), 1.0 (s, 3 H, 19-CH3), 0.92 (d, 3 H, 21CHS, J = 6.46 Hz), 0.87 (d, 6 H, 26 and 27-CH3, J = 6.54 Hz), 0.68 (s, 3 H, I8CH3). Anal.…”

“…Figure3. Tissue distribution of radioactivity in guinea pigs24 h after injection of 1MI-CIBE-gpLDL or 128I-gpLDL.…”

“…(s,3 H, 19-CH3), 0.89 (d,3 H, 2I-CH3, J = 6.46 Hz), 0.85 (d, 6 H, 26 and 27-CH3, J = 6.54 Hz), 0.68 (s, 3 H, I8-CH3). Anal.…”