Tumor microenvironment activated nanoenzyme-based agents for enhanced MRI-guided photothermal therapy in the NIR-II window

Chen, Ying; Liu, Yong; Kuang, Peipei; Guo, Chunmei; Zan, Jiahui; Xie, Chen; Yin, Chao; Fan, Quli

doi:10.1039/d1cc07195e

Cited by 3 publications

(3 citation statements)

References 18 publications

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Section: Dually/multiply‐activated Nir‐ii Phototheranostic Agentsmentioning

confidence: 99%

“…Fan et al. reported a TME pH/H 2 O 2 ‐activated NIR‐II phototheranostic (HTCFs), [19b] with CeO 2 −Fe 3 O 4 as a peroxidase mediator and TMB as an H 2 O 2 ‐activatable prodrug. The cancer cell membrane was employed as shells for extended plasma residence time and specific cell targeting.…”

Section: Dually/multiply‐activated Nir‐ii Phototheranostic Agentsmentioning

confidence: 99%

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Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Xiao,

Wu,

Tan

et al. 2024

Chemistry An Asian Journal

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Malignant tumors seriously threaten human life and well‐being. Emerging Near‐infrared II (NIR‐II, 1000‐1700 nm) phototheranostic nanotechnology integrates diagnostic and treatment modalities, offering merits including improved tissue penetration and enhanced spatiotemporal resolution. This remarkable progress has opened promising avenues for advancing tumor theranostic research. The tumor microenvironment (TME) differs from normal tissues, exhibiting distinct attributes such as hypoxia, acidosis, overexpressed hydrogen peroxide, excess glutathione, and other factors. Capitalizing on these attributes, researchers have developed TME‐activatable NIR‐II phototheranostic agents with diagnostic and therapeutic attributes concurrently. Therefore, developing TME‐activatable NIR‐II phototheranostic agents with diagnostic and therapeutic activation holds significant research importance. Currently, research on TME‐activatable NIR‐II phototheranostic agents is still in its preliminary stages. This review examines the recent advances in developing dual‐functional NIR‐II activatable phototheranostic agents over the past years. It systematically presents NIR‐II phototheranostic agents activated by various TME factors such as acidity (pH), hydrogen peroxide (H2O2), glutathione (GSH), hydrogen sulfide (H2S), enzymes, and their hybrid. This encompasses NIR‐II fluorescence and photoacoustic imaging diagnostics, along with therapeutic modalities, including photothermal, photodynamic, chemodynamic, and gas therapies triggered by these TME factors. Lastly, the difficulties and opportunities confronting NIR‐II activatable phototheranostic agents in the simultaneous diagnosis and treatment field are highlighted.

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Section: Dually/multiply‐activated Nir‐ii Phototheranostic Agentsmentioning

confidence: 99%

Section: Dually/multiply‐activated Nir‐ii Phototheranostic Agentsmentioning

confidence: 99%

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Xiao,

Wu,

Tan

et al. 2024

Chemistry An Asian Journal

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“…Based on this feature, some peroxidase-like nanozymes have also emerged as alternative tools for in vivo and in vitro therapy such as antibacterial therapy or tumor therapy taking advantage of the high oxidative capacity of ˙OH. 60,61…”

Section: The Enzyme-like Activities Of Nanozymes For Respiratory Dise...mentioning

confidence: 99%

Advances and perspectives of nanozymes in respiratory diseases

He¹,

Shi²,

Zheng³

et al. 2023

J. Mater. Chem. B

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Oxygen and hydrogen peroxide self-supplying magnetic nanoenzymes for cancer therapy through magneto-mechanical force, force-induced reactive oxygen species, chemodynamic effects, and cytotoxicity of Ca2+ ions

et al. 2023

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Tumor microenvironment activated nanoenzyme-based agents for enhanced MRI-guided photothermal therapy in the NIR-II window

Abstract: We report a nanoenzyme-based photothermal agent, in which the nanoenzyme acts as a peroxidase, prodrug carrier, and MRI contrast agent. The formation of dimer by the prodrug under the catalysis...

Cited by 3 publications

References 18 publications

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Advances and perspectives of nanozymes in respiratory diseases

Oxygen and hydrogen peroxide self-supplying magnetic nanoenzymes for cancer therapy through magneto-mechanical force, force-induced reactive oxygen species, chemodynamic effects, and cytotoxicity of Ca2+ ions

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