Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

Huang, Yu; Fan, Hui; Ti, Huihui

doi:10.1016/j.ajps.2024.100902

Asian Journal of Pharmaceutical Sciences

2024

DOI: 10.1016/j.ajps.2024.100902

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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

Yu Huang,

Hui Fan,

Huihui Ti

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Cited by 4 publications

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A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

Zhang,

Yu,

Guan

et al. 2024

Small Science

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To solve the oxygen dependence problem of photodynamic therapy (PDT), it is critical to explore photosensitizers that do not rely on O2 molecule to generate reactive oxygen species (ROS). Herein, a stable cationic metal‐organic cage [Pd6(RuLoz3)8](BF4)28 (MOC‐88) that possesses high +28 charges is designed. The cage‐confined positive microenvironment enables efficient generation of hydroxyl radicals and improved yield of the singlet oxygen under one‐/two‐photon excitation, showing excellent performance to concurrently enhance Type‐II and O2‐independent‐Type‐I PDT. Moreover, the effective ROS production and robust lipid peroxidation trigger a series of signaling pathways (inflammasome, cyclic guanosine monophosphate–adenosine monophosphate synthase stimulator of interferon genes, and NF‐κB) to evoke PANoptosis and ferroptosis in tumor cells, enabling MOC‐88 to simultaneously cause the loss of cell membrane integrity, release a series of inflammatory cytokines and damage‐associated molecular patterns, stimulate the maturation and antigen presentation ability of dendritic cells, and ultimately activate T‐cell‐dependent adaptive immunity in vivo to inhibit tumor growth.

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A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

Zhang,

Yu,

Guan

et al. 2024

Small Science

View full text Add to dashboard Cite

show abstract

Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy

Zeng,

Zhang,

Leng

et al. 2025

Critical Reviews in Oncology/Hematology

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Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy

Liu,

Wang,

et al. 2024

International Journal of Biological Macromolecules

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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

Cited by 4 publications

References 250 publications

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy

Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy

Contact Info

Product

Resources

About

Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

Cited by 4 publications

References 250 publications

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O2‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O2‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy

Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy

Contact Info

Product

Resources

About

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O₂‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis