Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent

Zhang, Yuan; Eltayeb, Omer; Meng, Yating; Zhang, Guomei; Zhang, Yan; Shuang, Shaomin; Dong, Chuan

doi:10.1039/c9nj05427h

Cited by 21 publications

(18 citation statements)

References 37 publications

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“…In other words, two types of transition metal elements are used to achieve efficient CDT via Fenton and/or Fenton‐like reaction at the same time. The currently reported dual metal ions‐mediated strategies are based on manganese/iron, [ 352–358 ] copper/iron, [ 359–365 ] copper/manganese, [ 366,367 ] etc.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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380

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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380

212

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“…Thus, more nanomaterials were studied to enable high catalytic efficiency in TME. Compared with Fe‐based catalysts, other metal catalysts (Mn 2+ , 33,34 Ti 3+ , 35 Cu 2+ , 36,37 and Mo 5+ 38 ) show different catalytic activities, which are dependent on pH changes. For instance, compared with Fe(II), Cu 2+ ions show higher catalytic activity at relatively higher pH values, which is close to the pH value in tumor sites 39…”

Section: Nanomaterials For Chemical Reactions In Catalytic Cancer Therapymentioning

confidence: 99%

Nanomaterials for cascade promoted catalytic cancer therapy

Tong

Gao

Huang

et al. 2021

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Catalytic therapy utilizing special substances (e.g., hydrogen peroxide and glucose) in tumor sites has attracted wide interest to achieve tumor‐specific therapy or improve the efficacy of other treatments. Benefiting from the selectivity and high activity of catalytic chemistry, efficient cancer therapy is available with negligible side effects. Numerous works, which are focused on further augmenting catalytic therapy with cascade strategies, have been reported with biocompatible nanomaterials composed of natural enzymes and/or nanozymes. Herein, we summarized catalytic reactions and nanomaterials in cascade strategy‐involved cancer therapy. With rapid advances in chemistry and nanomaterials, developing more selective and efficient cascade catalytic strategies will continue to be promising and challenging for cancer therapy.

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“…This is due to the rapid tumor growth, and the diffusion of oxygen and nutrients is limited. Metabolites such as lactate and glutathione, then accumulate, resulting in the tumor core becoming necrotic, surrounded by a peri-necrotic hypoxic cloistering of abnormal dividing cells [ 80 ]. The exploitation of metabolic targets can be achieved through direct means (metabolic enzymes) or indirect targets of disordered signaling pathways and the resultant microenvironment created.…”

Section: Controlled Gene and Drug Delivery Systemsmentioning

confidence: 99%

Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Moodley

Singh

2021

Pharmaceutics

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With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

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Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent

Abstract: We engineered a tumor microenvironment-triggered MSN-based anti-cancer nanocarrier for simultaneous delivery of DOX and chemodynamic agent.

Cited by 21 publications

References 37 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Nanomaterials for cascade promoted catalytic cancer therapy

Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

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