Tumor Microenvironment‐Responsive Polymer‐Based RNA Delivery Systems for Cancer Treatment
Yahan Zhang,
Ming Zhang,
Haiqin Song
et al.
Abstract:Ribonucleic acid (RNA) therapeutics offer a broad prospect in cancer treatment. However, their successful application requires overcoming various physiological barriers to effectively deliver RNAs to the target sites. Currently, a number of RNA delivery systems based on polymeric nanoparticles are developed to overcome these barriers in RNA delivery. This work provides an overview of the existing RNA therapeutics for cancer gene therapy, and particularly summarizes those that are entering the clinical phase. T… Show more
Polymer vectors hold great promise for application in gene therapy. However, some challenges such as low transfection efficiency, high toxicity, and insufficient cell selectivity still need to be addressed. Here,...
Polymer vectors hold great promise for application in gene therapy. However, some challenges such as low transfection efficiency, high toxicity, and insufficient cell selectivity still need to be addressed. Here,...
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