Tumor Necrosis Factor‐Alpha Levels After Surgical Anti‐Infective Mechanical Therapy for Peri‐Implantitis: A 12‐Month Follow‐Up

Mendonça, Adriana Cutrim de; Santos, Vanessa Renata; Neto, João Batista César; Duarte, Poliana Mendes

doi:10.1902/jop.2009.080521

Cited by 27 publications

(47 citation statements)

References 32 publications

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“…In line with previous findings, there were no differences with regards to IL-6, IL-8, IL-10 (Severino et al 2011), whereas the levels of IL-1β were significantly higher at peri-implantitis, compared to mucositis sites. Further studies also showed that peri-implantitis treatment reduced the PICF levels of IL-1β (Bassetti et al 2013) and TNF-α (de Mendonca et al 2009;Duarte et al 2009a). Studies have also demonstrated that single nucleotide polymorphisms (SNP) in the IL-1 gene may hold an increased risk for the development of peri-implantitis, particularly when combined with smoking (Andreiotelli et al 2008;Bormann et al 2010).…”

mentioning

confidence: 94%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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mentioning

confidence: 94%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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“…Mechanical peri-implant therapy leads to reduced TNF-α levels in the crevicular fluid associated with improved clinical parameters [12,13].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Particularities of the Implications of the Presence of Tumor Necrosis Factor Alpha in Patients with Periodontal Disease

Ieremie

Lazăr

Ciurba

2014

Acta Medica Marisiensis

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Periodontal disease can have significant effects by increasing the circulating levels of TNF-α, therefore its prevention and treatment is important in maintaining the overall health of the body. Objective: The aim of our research was to assess the differences in the salivary concentration of TNF-α between patients with periodontal disease and those free of the disease and to studz whether it can represent an indicator of the evolution of periodontal disease. We also aimed to assess the practical applicability of the method for the determination of this cytokine in the saliva. Materials and methods: Our study included two groups of subjects, the first group consisting in patients diagnosed with periodontal disease, while the control group included subjects free of periodontal disease. TNF-α concentration was determined with the ELISA test for human TNF-α and the results were expressed in pg/ mL. The data were statistically processed with GraphPad software and the statistical nonparametric Mann-Whitney test was applied. Results: We observe nearly double values of the TNF-α salivary level in the group of patients suffering from periodontal disease compared to the subjects free of periodontal disease, which allows us to notice that saliva analysis is a useful and safely enough method for the diagnosis and follow-up in the development of periodontal disease. Conclusion: The salivary level of TNF-α in patients with periodontal disease is not only an indicator of periodontal disease progression, but also a reflection of the pathogen potential that periodontal disease may have on the overall health of the body.

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“…Pathogenic species stimulate proinflammatory cytokines, such as interleukin (IL)-1b, IL-6, and tumor necrosis factor (TNF)-a, which coordinate many aspects of the local inflammatory response. 35 TNF-a subsequently induces more adhesion molecules, proinflammatory cytokines, and chemokines as well as induces osteoclast function resulting in bone loss. Peri-implant crevicular fluid TNF-a may be an indicator for peri-implant inflammation and may precede indicators such as BOP increased probing depth (PD), providing for an earlier diagnosis.…”

Section: Genetic Factorsmentioning

confidence: 99%

“…Peri-implant crevicular fluid TNF-a may be an indicator for peri-implant inflammation and may precede indicators such as BOP increased probing depth (PD), providing for an earlier diagnosis. 35 There is potential for genetic alterations of any of the above factors to influence periimplantitis. IL-1 is a group of 11 cytokines that are involved in the regulation of immune and inflammatory responses.…”

Section: Genetic Factorsmentioning

confidence: 99%