Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy

Ternström, Lisa; Jeppsson, Anders; Ricksten, Anne; Nilsson, Folke

doi:10.1016/j.healun.2004.02.019

Cited by 26 publications

(24 citation statements)

References 30 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27,28 In the clinic, elevated TNF-␣ production is associated with increased cardiac allograft vasculopathy and mortality in heart transplant recipients. 13 In cholesterol-fed rabbits with heterotopic cardiac transplants, blockade of TNF-␣ inhibits acute coronary lesion formation 8 days after transplantation with the same molecule used in this study. 19 However, TNF-R1 deficiency does not abrogate the development of arteriosclerotic lesions in mice cardiac allografts at 8 to 12 weeks after transplantation.…”

Section: Discussionmentioning

confidence: 90%

“…12 Elevated TNF-␣ production has been associated with increased incidence of cardiac allograft arteriosclerosis and mortality in cardiac transplant recipients. 13 Simvastatin has recently been shown to decrease myocardial TNF-␣ expression, which may explain its beneficial effect on patient survival and rejection episodes. 14 However, increased TNF-␣ production was not associated with increased risk of rejection in adult cardiac transplant recipients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Tumor Necrosis Factor-α Attenuates Myocardial Remodeling in Rat Cardiac Allografts

Sihvola

Koskinen

Pulkkinen

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Inhibition of Tumor Necrosis Factor-α Attenuates Myocardial Remodeling in Rat Cardiac Allografts

Sihvola

Koskinen

Pulkkinen

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…33,34 Comparable mechanisms may apply to HTx recipients; that is, associations between pro-inflammatory cytokine levels and increased risk of rejection might be related to increased psychologic distress. TNF-␣ is a potent pro-inflammatory cytokine that is produced in cardiac allografts, and has been associated with the development of cardiac allograft vasculopathy, 35 cardiac allograft hypertrophy 36 and right ventricular failure 37 in heart transplant recipients. Evidence has also suggested that a statinmediated decrease in TNF-␣ expression may have a beneficial effect on survival and rejection post-HTx.…”

mentioning

confidence: 99%

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Denollet

Vrints

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Unfavorable outcome of heart transplantation in recipients with type D personalityDenollet, Johan; Holmes, R.V.F.H.; Vrints, C.J.; Conraads, V. Published in:The Journal of Heart and Lung Transplantation Document version:Publisher's PDF, also known as Version of record General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: The role of personality in heart transplantation (HTx) remains largely unknown. We examined the distressed personality (Type D) as a predictor of outcomes in patients suffering from end-stage heart disease who underwent HTx. Methods:Using the DS14 scale, 51 patients (75% men; 54.1 Ϯ 9.7 years of age) were diagnosed as Type D or non-Type D in the pre-transplant period. End-points of this prospective follow-up study (mean 5.4 years) were mortality and allograft rejection (Grade Ն3A rejection, rejection-free days after HTx). Results:At baseline, 15 patients were diagnosed as Type D and 36 as non-Type D; they did not differ in recipient or donor characteristics. At follow-up, there were 8 deaths; the mortality rate of Type D recipients was 33% vs 8% for non-Type Ds ( p ϭ 0.036). Two deaths were due to early post-operative complications and were excluded from further analyses. Type D recipients had a 10-fold higher mortality rate after hospital discharge (5 of 15, or 33%) as compared with non-Type D recipients (1 of 34, or 3%) ( p ϭ 0.013, adjusting for age and gender). Among surviving recipients, the rate of Grade Ն3A rejection for both groups was 40% vs 27%, respectively (p ϭ 0.45). The first episode of rejection was diagnosed, on average, after 14 days in Type D recipients vs after 50 days in the other patients (p ϭ 0.032). The risk of unfavorable outcomes (death, Grade Ն3A rejection, or number rejection-free days Յ14) was greater in Type D recipients (12 of 15, or 80%) than in non-Type Ds (13 of 34, or 38%), adjusting for other risk factors (odds ratio: 6.75; 95% confidence interval: 1.47 to 30.97) ( p ϭ 0.014). Conclusions: Type D personality independently predicted mortality and early allograft rejection, and should be accounted for when planning interventions to achieve optimal outcomes after HTx. J Heart Lung Transplant 2007;26:152-8.

show abstract

“…Numerous cytokine SNPs have been studied in relation to immune function, and strong associations have been established with the outcome of solid organ and hematopoietic stem cell transplantation, 12,19,20 as well as with infection (viral, bacterial, and parasitic), shock, and autoimmune diseases. 21 Mira et al reported an association of the higher producing TNF (Ϫ308A) SNP with septic shock susceptibility and mortality, 22 and Imahara et al linked this SNP to increased risk of severe sepsis in trauma patients.…”

Section: Resultsmentioning

confidence: 99%

The TNF (−308A) polymorphism is associated with microchimerism in transfused trauma patients

Gill

Lee

Utter

et al. 2008

Blood

View full text Add to dashboard Cite

Microchimerism (MC), defined as the persistence of allogeneic cells at low concentrations, is well documented in transfused trauma patients. We hypothesized that genetic polymorphisms linked to cytokine production could contribute to trauma-induced immune modulation and development of microchimerism after transfusion of trauma patients. We used high-throughput SYBR-green-based genotyping of single

show abstract

Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy

Cited by 26 publications

References 30 publications

Inhibition of Tumor Necrosis Factor-α Attenuates Myocardial Remodeling in Rat Cardiac Allografts

Inhibition of Tumor Necrosis Factor-α Attenuates Myocardial Remodeling in Rat Cardiac Allografts

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

The TNF (−308A) polymorphism is associated with microchimerism in transfused trauma patients

Contact Info

Product

Resources

About