Tumor Necrosis Factor Gene Polymorphisms in Tunisian Patients With Behçet’s Disease

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

“…The frequency of the -1031C allele was similar to that reported in a case control study on 1213 post-MI patients and 1561 healthy controls (32). In addition, the genotype and allele frequencies of control individuals were comparable to those previously reported for healthy Tunisian controls (33), which were similar to frequencies established for other ethnic groups, including healthy Swedish (32) and pan-Brazilian (34) individuals. The association between the two TNF-a loci and CAD was also studied by haplotype analysis.…”

The Tumor Necrosis Factor-A (TNF-A) Gene -308 G/A Polymorphism and the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Gene Polymorphisms in Behcet'S Disease

“…Kamoun et al (2007) (9) studied both the 1031T/C and 308 A/G TNF-α gene promoter polymorphisms among tunisian patients. the frequency of TNF-α-1031C allele was indeed significantly higher in BD patients than in healthy controls, whereas the frequencies of TNF-α-308G and TNF-β 252G alleles were with similar frequencies.…”

Insights into Behçet’s disease

“…The frequency of TNF-α-1031C allele was certainly significantly higher in BD patients than in healthy controls, whereas the frequencies of TNF-α 308G and TNF-β 252G alleles were similar in the two groups. A study in Iranian Azeri Turkish patients showed the relation between TNF-α1031T/C and TNF-α308G/A polymorphisms and susceptibility to BD with the frequency of the TNF-α1031C allele being significantly higher in Behçet's patients than in healthy controls; whereas the frequency of the TNF-α308A allele was similar in the two compared groups [11][12][13][14][15].…”