Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne

Akoğlu, Gülşen; Tan, Çağman; Çağdaş, Deniz; Tezcan, İlhan

doi:10.1111/jocd.12558

Cited by 11 publications

(13 citation statements)

References 30 publications

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“…IL-1β is a proinflammatory cytokine suggested to play a key role in the pathogenesis of acne. 4,6 In the current study, IHC expression of IL-1β was positive in all acne patients. It was significantly higher in acne patients and acne scars compared with controls (p < 0.001) for both.…”

Section: Discussionsupporting

confidence: 50%

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Study of interleukin‐1 beta expression in acne vulgaris and acne scars

El-Attar

Mourad

Alngomy

et al. 2022

J of Cosmetic Dermatology

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Background Acne vulgaris is a multifactorial disease that mostly heals by scarring. Interleukin‐1 beta (IL‐1β) is a proinflammatory cytokine, suggested to play a key role in acne pathogenesis. Objective To study the immunohistochemical (IHC) expression of IL1β in acne vulgaris and acne scars to evaluate its possible role in their pathogenesis and to study the relation between the expression of IL1β and the clinicopathological parameters. Patients and methods This study was conducted on sixty subjects (twenty patients with acne vulgaris and twenty patients with acne scars), and twenty healthy volunteers as controls. Skin biopsies were taken from patients and controls for routine histopathological examination with hematoxylin and eosin stain and IHC staining of IL‐1β. Results There was a statistically significant increase in expression of IL‐1β in acne vulgaris compared with post‐acne scars and controls, (p < 0.001) for both. IL‐1β expression was significantly positively correlated with both clinical severity of acne vulgaris (p = 0.022) and severity of histopathological inflammation (p = 0.011). Conclusion Interleukin‐1β expression was associated with acne vulgaris and post‐acne scars with significant positive correlation to clinical and histopathological severity of acne vulgaris. Thus, IL‐1β could be a key player cytokine in acne pathogenesis, its severity and development of post‐acne scars.

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Section: Discussionsupporting

confidence: 50%

“…Interleukin‐1 beta (IL‐1β) is a proinflammatory cytokine mainly released from activated T lymphocytes and macrophages, 4 in response to many pathogen associated molecular patterns and damage‐associated molecular patterns 5 . Its induction plays an important role in the inflammatory cascade of acne.…”

Section: Introductionmentioning

confidence: 99%

Study of interleukin‐1 beta expression in acne vulgaris and acne scars

El-Attar

Mourad

Alngomy

et al. 2022

J of Cosmetic Dermatology

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“…Similar results were observed in a study conducted on Turkish population. TNF-α levels were significantly elevated in severe acne patients ( Akoglu et al, 2019 ). We found that polymorphism at −1031 is not associated with acne and high frequency of −857 T allele in controls shows that it may has protective role in acne development.…”

Section: Discussionmentioning

confidence: 99%

Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris

Younis

Shamim

Nisar

et al. 2021

Saudi Journal of Biological Sciences

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Background Acne is an inflammatory condition principally affected by genetic and dietary factors. Investigation into functional polymorphisms of TNF-α gene and their association with acne vulgaris will be helpful in exploring genetic influence on skin immune mediated inflammatory events. In the present study, we analyzed association of TNF-α gene polymorphisms, its expression levels and lipid profiles in a large cohort of acne patients and controls. Methods We used PCR-RFLP to study association of TNF-α polymorphisms at −857C/T, −863C/A and −1031 T/C sites with acne vulgaris. Lipid profiles were measured using enzymatic end-point method. The serum levels of TNF-α and apolipoprotein a were measured using ELISA. NIH, LDlink was used to investigate patterns of linkage disequilibrium across south Asian reference genome (Punjabi from Lahore Pakistan). Results We found that TNF-α −863 polymorphism is strongly associated with acne in overall population as well as in gender and severity based groups of acne patients. Polymorphisms at −863 and −1031 position were in linkage disequilibrium. Importantly, TNF-α serum level was significantly increased in acne patients with severe disease symptoms. Furthermore, levels of total cholesterol (TC) and triglycerides (TG) were significantly increased, whereas high density lipoprotein cholesterol (HDL-C) level was significantly decreased in acne patients. The levels of apolipoprotein a varied widely in studied populations and no significant difference was found in the analyzed groups. Conclusion In conclusion, we found that TNF-α expression increases in acne patients affected by TNF-α polymorphisms, and that the lipid profile is specifically disrupted in acne patients.

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“…Inflammatory pathways such as nuclear factor kB, activator protein 1, and toll-like receptor activate the inflammatory cascade, promote local chemotaxis of inflammatory cells, destroy pilosebaceous units, aggravate local tissue damage, and promote scar formation. 5…”

Section: Pathogenesis Of Acne Scarsmentioning

confidence: 99%

Consensus on Treatment of Acne Scars in China (2021) #

Yang

Liu

Lin

et al. 2022

International Journal of Dermatology and Venereology

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Acne scars are caused by inflammatory reactions, infections, and improper handling of acne lesions. Such scars have a high incidence and are difficult to treat. There are many methods currently used to treat acne scars, including medications, photoelectric technology, surgery, filling, chemical peeling, traditional Chinese medicine, biotherapy, and microneedle therapy, and many new methods are constantly emerging. However, there are still many issues, such as the lack of high-quality clinical studies, non-uniform treatment methods, and unsatisfactory therapeutic effects. The selection of appropriate methods for the comprehensive treatment of different types of acne scars at different stages in clinical practice remains challenging and is a research topic of great interest. From the perspective of evidence-based medicine, this consensus aims to provide a reference for the treatment of acne scars in clinical practice.

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Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne

Abstract: TNF α-308 and IL-1β polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.

Cited by 11 publications

References 30 publications

Study of interleukin‐1 beta expression in acne vulgaris and acne scars

Study of interleukin‐1 beta expression in acne vulgaris and acne scars

Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris

Consensus on Treatment of Acne Scars in China (2021) #

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