Tumor radiosensitization by photobiomodulation

Faria, Clara Maria Gonçalves de; Barrera-Patiño, Claudia P.; Santana, Jhone P.P.; Avó, Lucimar Retto da Silva de; Bagnato, Vanderlei Salvador

doi:10.1016/j.jphotobiol.2021.112349

Cited by 12 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although PBM is mainly reported to mitigate side effects of radiation, a few studies addressed its radiosensitizing potential (39)(40)(41). Djavid and coworkers (39) showed that PBM at 685 nm and 5 J/cm 2 before exposure to radiation significantly inhibited clonogenic growth of HeLa cells.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo, Faria et al ( 41 ) used PBM (780 nm, 5 J, and 20 mW.cm –2 ) before irradiation (15 Gy) in xenografic human epidermoid tumors induced in mice. The authors reported a delay in tumor progression and a few regions of necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…There is no standard radiation therapy protocol for all cancers, though it is often determined according to the type of cancer, stage, grade, and whether radiation is applied as a single or adjuvant treatment (4)(5)(6). For example, the European Society for Radiotherapy and Oncology Advisory in Radiation Oncology defined parameters of a moderate hypofractionation protocol (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56) Gy in 15 or 16 fractions over 3 weeks) for treatment of the whole breast regardless of the age at breast cancer diagnosis, pathological tumor stage and breast cancer biology (7). Nonetheless, there are still challenges in radiotherapy to be overcome, such as minimizing the damage to normal cells/tissue surrounding the tumor and importantly, tumor radioresistance (8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model

Silva,

Pereira,

Silva

et al. 2023

Radiation Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model

Silva,

Pereira,

Silva

et al. 2023

Radiation Research

View full text Add to dashboard Cite

“…69 Despite its positive effects on cell proliferation and migration, PBM does not appear to induce tumorigenesis or tumor growth, and may in fact have a radiosensitizing effect on tumors. [70][71][72][73][74] PBM has a biphasic dose response, with greater effects seen at lower doses. 67 The optimal wavelength and dosing for PBM likely depend on tissue type, injury type, and depth of injury; Zecha et al recommend the following regimen: wavelength of 633 to 685 nm or 780 to 830 nm; power output of 10 to 150 mW; energy density of 2 to 6 J/cm 2 ; frequency ranging from two to three times a week to daily; successive intraoral applications to single spots, rather than scanning the entire mucosa; and using a pulsed laser rather than a continuous wave light.…”

Section: Paliferminmentioning

confidence: 99%

Section: Prophylactic Treatments Studied In Head and Neck Cancer Pati...mentioning

confidence: 99%

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Kim

Rubenstein

Chu

et al. 2022

J Reconstr Microsurg

View full text Add to dashboard Cite

Background Radiation-associated soft tissue injury is a potentially devastating complication for head and neck cancer patients. The damage can range from minor sequelae such as xerostomia, which requires frequent daily maintenance, to destructive degenerative processes such as osteoradionecrosis, which can contribute to flap failure and delay or reverse oral rehabilitation. Despite the need for effective radioprotectants, the literature remains sparse, primarily focused on interventions beyond the surgeon's control, such as maintenance of good oral hygiene or modulation of radiation dose. Methods This narrative review aggregates and explores noninvasive, systemic treatment modalities for prevention or amelioration of radiation-associated soft tissue injury. Results We highlighted nine modalities with the most clinical potential, which include amifostine, melatonin, palifermin, hyperbaric oxygen therapy, photobiomodulation, pentoxifylline–tocopherol–clodronate, pravastatin, transforming growth factor-β modulators, and deferoxamine, and reviewed the benefits and limitations of each modality. Unfortunately, none of these modalities are supported by strong evidence for prophylaxis against radiation-associated soft tissue injury. Conclusion While we cannot endorse any of these nine modalities for immediate clinical use, they may prove fruitful areas for further investigation.

show abstract

Progression in low‐intensity ultrasound‐induced tumor radiosensitization

Xu,

Liu,

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

BackgroundRadiotherapy (RT) is a widely utilized tumor treatment approach, while a significant obstacle in this treatment modality is the radioresistance exhibited by tumor cells. To enhance the effectiveness of RT, scientists have explored radiosensitization approaches, including the use of radiosensitizers and physical stimuli. Nevertheless, several approaches have exhibited disappointing results including adverse effects and limited efficacy. A safer and more effective method of radiosensitization involves low‐intensity ultrasound (LIUS), which selectively targets tumor tissue and enhances the efficacy of radiation therapy.MethodsThis review summarized the tumor radioresistance reasons and explored LIUS potential radiosensitization mechanisms. Moreover, it covered diverse LIUS application strategies in radiosensitization, including the use of LIUS alone, ultrasound‐targeted intravascular microbubble destruction, ultrasound‐mediated targeted radiosensitizers delivery, and sonodynamic therapy. Lastly, the review presented the limitations and prospects of employing LIUS‐RT combined therapy in clinical settings, emphasizing the need to connect research findings with practical applications.Results and ConclusionLIUS employs cost‐effective equipment to foster tumor radiosensitization, curtail radiation exposure, and elevate the quality of life for patients. This efficacy is attributed to LIUS's ability to utilize thermal, cavitation, and mechanical effects to overcome tumor cell resistance to RT. Multiple experimental analyses have underscored the effectiveness of LIUS in inducing tumor radiosensitization using diverse strategies. While initial studies have shown promising results, conducting more comprehensive clinical trials is crucial to confirm its safety and effectiveness in real‐world situations.

show abstract

Tumor radiosensitization by photobiomodulation

Cited by 12 publications

References 34 publications

Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model

Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Progression in low‐intensity ultrasound‐induced tumor radiosensitization

Contact Info

Product

Resources

About