2024
DOI: 10.4062/biomolther.2024.029
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Tumor Stroma as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

Dae Ui Lee,
Beom Seok Han,
Kyung Hee Jung
et al.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis owing to its desmoplastic stroma. Therefore, therapeutic strategies targeting this tumor stroma should be developed. In this study, we describe the heterogeneity of cancer-associated fibroblasts (CAFs) and their diverse roles in the progression, immune evasion, and resistance to treatment of PDAC. We subclassified the spatial distribution and functional activity of CAFs to highlight their effects on prognosis and drug delivery. Extracellular matrix c… Show more

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