Tumor-targeted liposomes with platycodin D2 promote apoptosis in colorectal cancer

Cho, Euni; Mun, Seok-Jun; Jeon, Min Hwan; Kim, Hyo Keun; Baek, Hwira; Ham, Yu Seong; Gil, Woo Jin; Kim, Jinwoong; Yang, Chul–Su

doi:10.1016/j.mtbio.2023.100745

Cited by 3 publications

(4 citation statements)

References 45 publications

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“…Liposomes target apoptosis in cancer cells, making them attractive cancer treatments [ 59 ]. Customized lipid vesicles can transport therapeutic chemicals directly to cancer cells, causing apoptosis and limiting tumor growth [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

“…The following hotspots were inferred from the four mentioned clusters obtained from both VOSviewer and Biblioshiny (Figures 4 and 5). Liposomes target apoptosis in cancer cells, making them attractive cancer treatments [59]. Customized lipid vesicles can transport therapeutic chemicals directly to cancer cells, causing apoptosis and limiting tumor growth [60].…”

Section: Research Trends and Hotspotsmentioning

confidence: 99%

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Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Hamad,

Harb,

Bustanji

2024

Pharmaceutics

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Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role in drug delivery. With their amphiphilic design, liposomes efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise in advancing cancer therapy methodologies. Bibliometric research analyzes systematic literary data statistically. This study used bibliometric indicators to examine, map, and evaluate the applications of liposomes in cancer therapy. A Scopus search was conducted to identify all English-language peer-reviewed scientific publications on the applications of liposomes in cancer therapy within the past twenty years. Bibliometric indicators were calculated using VOSviewer and Biblioshiny. We produced thematic, conceptual, and visualization charts. A total of 14,873 published documents were obtained. The procedure of keyword mapping has effectively identified the main areas of research concentration and prevailing trends within this specific field of study. The significant clusters discovered through theme and hotspot analyses encompassed many topics such as the use of multiple strategies in chemotherapy and different forms of cancer, the study of pharmacokinetics and nanomedicine, as well as the investigation of targeted drug delivery, cytotoxicity, and gene delivery. Liposomes were employed as drug delivery systems so as to selectively target cancer cells and improve the bioavailability of anticancer drugs. The work showcased the capacity to tailor these liposomes for accurate drug delivery by including potent anticancer medications. Our findings not only bring attention to the latest progress in utilizing liposomes for cancer treatment but also underscore the vital need for ongoing research, collaborative efforts, and the effective translation of these breakthroughs into tangible clinical applications, emphasizing the dynamic and evolving nature of cancer therapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Research Trends and Hotspotsmentioning

confidence: 99%

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Hamad,

Harb,

Bustanji

2024

Pharmaceutics

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“…Several liposomal delivery systems have shown promise in enhancing drug targeting and efficacy for colon cancer. The lactoferrin-modified liposome delivery system (LF lipo) (R. Wang, Qu, et al, 2023), the acidity (PCD2 Lipo ATRAM) modified liposome delivery system (Cho et al, 2023) and the camel α-lactalbumin coated liposomes (El-Fakharany et al, 2023) encapsulating therapeutic agents have demonstrated a significant improvement in drug enrichment in tumors, indicating its potential importance in advancing clinical treatments for colon cancer.…”

Section: Application Of Liposomes In Other Organ Repairmentioning

confidence: 99%

“…Luo, Z., Ji, L., Liu, H., Sun, Y., Zhao, C., Xu, X., Gu, X., Ai, X., & Yang, C. (2023). Inhalation lenalidomide-loaded liposome for bleomycininduced pulmonary fibrosis improvement.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

The application strategy of liposomes in organ targeting therapy

Xun,

Li,

Xue

2024

WIREs Nanomed Nanobiotechnol

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Liposomes—microscopic phospholipid bubbles with bilayered membrane structure—have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ‐specific diseases. For further successful development of this field, this review summarized liposomal strategies for targeting different organs in series of major human diseases, including widely studied cardiovascular diseases, liver and spleen immune diseases, chronic or acute kidney injury, neurodegenerative diseases, and organ‐specific tumors. It highlights recent advances of liposome‐mediated therapeutic agent delivery for disease intervention and organ rehabilitation, offering practical guidelines for designing organ‐targeted liposomes.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures

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The Art of Liposome Surface Decoration for Targeted Drug Delivery

B. Safari,

Maseko,

B. Lokole

et al. 2024

Liposomes - A Modern Approach in Research [Working Title]

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This chapter delves into the intricate art of surface modification of liposomes, a versatile group of nanocarriers renowned for their pivotal role in various fields, including drug delivery, diagnostics, and theranostics. Emphasising the significance of surface modification, this chapter outlines the methods employed to design liposomes with added functionalities, improved stability, and targeted delivery capabilities. The chapter offers a comprehensive overview of modern surface modification strategies from traditional conjugation chemistry to innovative bioinspired and biomimetic methods. Additionally, it meticulously examines the use of various ligands—including peptides, antibodies, proteins, and polymers—to embellish liposomal exteriors, thereby achieving enhanced biocompatibility, extended circulation times, and targeted delivery. Furthermore, the discussion extends to the implications of these surface modifications, highlighting how they influence the biological fate of liposomes, from cellular interactions to their behaviour in vivo. Through this exploration, the chapter aims to provide an extensive understanding of the current landscape and prospects of liposomal surface modification, fostering advancements in nanomedicine.

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Tumor-targeted liposomes with platycodin D2 promote apoptosis in colorectal cancer

Cited by 3 publications

References 45 publications

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

The application strategy of liposomes in organ targeting therapy

The Art of Liposome Surface Decoration for Targeted Drug Delivery

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