Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

Recent developments in the design of bifunctional and activatable photo sensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, the most promising results have come from studies aimed at gaining precise control over the location and rate of cytotoxic singlet oxygen generation. As a consequence, higher selectivities and efficiencies in photodynamic treatment protocols are now within reach. This feature article highlights the variety of approaches that have been pur sued to improve photodynamic therapy and to transform simple photosensi tizers into smarter theranostic agents.

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“…[63] Dong and co-workers recently described a protein-activated theranostic agent. [64] This system is composed of nanoparticles Adv. Funct.…”

Section: Enzymes/proteins Overexpressed In Cancer Cells Activate Specmentioning

confidence: 99%

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Kölemen

Yoon

et al. 2016

Adv Funct Materials

439

325

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“…An updated overview on the development of new photosensitizers for anticancer photodynamic therapy was reported by Zhang et al, [30]. More clinical studies of the efficacy of PDT and PTT using various nanoparticles have been reported [31][32][33][34][35][36][37][38][39].…”

Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 99%

Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin¹,

Chen²,

Liu³

2017

Med Devices Diagn Eng

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“…In most cases, the core–shell structure of polymeric nanoparticles comprises a hydrophilic surface layer for stabilizing in blood circulation and a hydrophobic interior core for loading therapeutic agents including anticancer drugs or PSs . Encapsulating BODIPY PSs with a tumor‐targeting amphiphilic polymer to generate nano‐photosensitizers is a promising strategy to overcome the drawbacks of self‐assembly NPs and enhance photosensitizer concentration in the tumor …”

Section: Bodipy Nano‐photosensitizers For Pdtmentioning

confidence: 99%

“…Shi et al grafted diiodostyryl BODIPY to hyaluronic acid (HA), causing the spontaneous assembly of uniform NPs in water with a mean diameter of 50 nm ( Figure ) . These NPs exhibited specific tumor targeting due to the overexpression of the HA receptor, CD44, in tumor cells.…”

Section: Bodipy Nano‐photosensitizers For Pdtmentioning

confidence: 99%

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Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Sun

Zhao

Fan

et al. 2019

Small

154

116

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As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY‐containing nano‐photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano‐photosensitizers demonstrate a promising potential for fighting cancer. This review contains three sections, classifying photodynamic therapy (PDT), photothermal therapy (PTT), and the combination of PDT and PTT based on BODIPY nano‐photosensitizers. It summarizes various BODIPY nano‐photosensitizers, which are prepared via different approaches including molecular precipitation, supramolecular interactions, and polymer encapsulation. In each section, the design strategies and working principles of these BODIPY nano‐photosensitizers are highlighted. In addition, the detailed in vitro and in vivo applications of these recently developed nano‐photosensitizers are discussed together with future challenges in this field, highlighting the potential of these promising nanoagents for new tumor phototherapies.

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Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

Abstract: On-site activated diiodostyryl bodipy conjugated HA nanoparticles with specific targets synthesized via self-assembly were used for the suppression of tumor growth and exact tumor diagnosis with reduced side effects.

Cited by 57 publications

References 50 publications

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Progress of nanotechnology for phototherapy: Fundamentals and applications

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

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