Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma

Garay, M.I.; Comba, Andrea; Vara-Messler, Marianela; Barotto, N.N.; Silva, R.A.; Repossi, G; Quiroga, Patricia; Mazzudulli, G.M.; Brunotto, Mabel; Pasqualini, Marìa Eugenia

doi:10.1016/j.prostaglandins.2021.106564

Cited by 5 publications

(33 citation statements)

References 33 publications

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“…The eligibility analysis excluded a further five articles—three studies reported only in vitro results and two did not use the BC model. Thus, only 27 unduplicated full-text articles [ 17 , 18 , 19 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] were included in this systematic review, 19 from PubMed and 8 from Scopus, as shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The breast tumor experimental model most used in the selected studies was the conventional tumor cell transplant in specific tissue regions of animal models (69%) [ 17 , 18 , 19 , 39 , 42 , 43 , 45 , 46 , 49 , 50 , 51 , 53 , 55 , 57 , 58 , 59 , 60 , 61 , 62 ], followed by the model of spontaneous tumor generation using transgenic animals (17%) [ 40 , 41 , 47 , 52 , 55 , 56 ], and lastly, 14% of studies induced BC in the animal model by carcinogenic drug transplant [ 44 , 48 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies utilized the in vivo murine model—93% mice [ 17 , 18 , 19 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] and 7% in rats [ 48 , 54 ]. The breast tumor model by cell transplant was performed in 64% of studies using different cell sources, 70% from humans [ 17 , 18 , 19 , 45 , 49 , 50 , 51 , 53 , 55 , 58 , 59 , 60 , 61 , 62 ] and 30% from mice [ 39 , 42 , 43 , 46 , 53 , 57 ], and in 17% of studies, transgenic animals developed the tumor spontaneously [ 40 , 41 , 47 , …”

Section: Resultsmentioning

confidence: 99%

“…Regarding the mice strain, the studies used mainly Balb/c (57%) [ 18 , 19 , 39 , 42 , 43 , 44 , 45 , 51 , 53 , 55 , 57 , 58 , 59 , 60 , 61 , 62 ], and among this group 44% were the nude type ( nu / nu ) [ 18 , 19 , 45 , 51 , 55 , 57 , 58 , 59 , 60 , 61 , 62 ], 44% were the wildtype [ 39 , 42 , 43 , 44 , 53 , 57 , 60 ], and two mice showed genetic modifications ( Foxn1nu [ 58 ] and J:nu [ 19 ]). The breast tumor model by cell transplant used Balb/c mice almost exclusively, and in only one study the Balb/c wildtype had the tumor induced by a drug [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…Female murines were predominantly used in the selected studies (83%) [ 17 , 18 , 39 , 40 , 41 , 42 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 61 , 62 ], with male-only in 3% [ 19 ], both animal sexes in 7% [ 43 , 60 ], and in 7% of studies this information was not reported [ 46 ]. Regarding the animals’ ages, 36% of the selected studies used young mice in the development phase, from 3 to 5 weeks [ 18 , 40 , 41 , 49 , 52 , 55 , 56 , 58 , 59 , 61 ], 36% of studies used adult mice at 6 weeks of age [ 17 , 39 , 45 , 50 , 51 , 53 , 55 , 57 , 62 ], 14% used adult mice between 7 and 8 weeks of age [ 39 , 42 , 44 ,…”

Section: Resultsmentioning

confidence: 99%

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The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

et al. 2023

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In order to understand how omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements affect breast cancer prevention and treatment, a systematic review of articles published in the last 5 years in two databases was performed. Of the 679 articles identified, only 27 were included and examined based on five topics, taking into account: the induction type of the breast cancer used in animal models; the characteristics of the induction model by cell transplantation; the experimental design of the ω-3 supplementation—combined or not with a treatment antitumor drug; the fatty acids (FAs) composition used; the analysis of the studies’ outcomes. There are diverse and well-established animal models of breast cancer in the literature, with very relevant histological and molecular similarities depending on the specific objective of the study, such as whether the method of tumor induction was transgenic, by cell transplantation, or by oncogenic drugs. The analyses of outcomes were mainly focused on monitoring tumor growth, body/tumor weight, and molecular, genetic, or histological analyses, and few studies evaluated latency, survival, or metastases. The best results occurred when supplementation with ω-3 PUFA was associated with antitumor drugs, especially in the analysis of metastases and volume/weight of tumors or when the supplementation was started early and maintained for a long time. However, the beneficial effect of ω-3 PUFA supplementation when not associated with an antitumor agent remains unclear.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

et al. 2023

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The association among TP53 rs1042522, pri-miR 34b/c rs4938723 polymorphisms and daily dietary fatty acids in patients with premalignant and malignant oral lesions

et al. 2022

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Erythrocyte membrane n-3 PUFA are inversely associated with breast cancer risk among Chinese women

Zhang

Shi

et al. 2023

Br J Nutr

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The relationship between erythrocyte membrane n-3 polyunsaturated fatty acid (n-3 PUFA) and breast cancer risk is controversial. We aimed to examine the associations of erythrocyte membrane n-3 PUFA with odds of breast cancer among Chinese women by using a relatively large sample size. A case-control study was conducted including 853 newly diagnosed, histologically-confirmed breast cancer cases and 892 frequency-matched controls (5-year interval). Erythrocyte membrane n-3 PUFA were measured by gas chromatography. Logistic regression and restricted cubic spline were used to quantify the association between erythrocyte membrane n-3 PUFA and odds of breast cancer. Erythrocyte membrane α-linolenic acid (ALA), docosapentaenoic acid (DPA) and total n-3 PUFA were inversely and non-linearly associated with odds of breast cancer. The odds ratio (OR) values [95% confidence intervals (CIs)], comparing the highest with the lowest quartile (Q), were 0.57 (0.43-0.76), 0.43 (0.32-0.58) and 0.36 (0.27-0.49) for ALA, DPA and total n-3 PUFA, respectively. Erythrocyte membrane eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) were linearly and inversely associated with odds of breast cancer [ (EPA: ORQ4vs.Q1 (95% CI) = 0.59 (0.45–0.79); DHA: ORQ4vs.Q1 (95% CI) = 0.50 (0.37–0.67)]. The inverse associations were observed between ALA and odds of breast cancer in postmenopausal women, and between DHA and ER+ breast cancer. This study showed that erythrocyte membrane total and individual n-3 PUFA were inversely associated with odds of breast cancer. Other factors, such as menopause and hormone receptor status, may warrant further investigation when examining the association between n-3 PUFA and odds of breast cancer.

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Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma

Cited by 5 publications

References 33 publications

The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments

The association among TP53 rs1042522, pri-miR 34b/c rs4938723 polymorphisms and daily dietary fatty acids in patients with premalignant and malignant oral lesions

Erythrocyte membrane n-3 PUFA are inversely associated with breast cancer risk among Chinese women

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