Tumour and surgery effects on cognitive functioning in high-grade glioma patients

Habets, Esther J. J.; Kloet, Alfred; Walchenbach, Rob; Vecht, Charles J.; Klein, Martin; Taphoorn, Martin J.B.

doi:10.1007/s00701-014-2115-8

Cited by 106 publications

(87 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 With regard to tumor laterality, patients with left-sided meningiomas had decreased verbal fluency and recall for verbal material compared with patients with right-sided meningiomas. This finding supports the well-established notion that the left hemisphere is dominant for language function 15 and is in agreement with previous studies reporting verbal deficits in patients with left-hemisphere benign, 28 low-grade, 9 and high-grade malignancy 12 tumors. Regarding the superoinferior axis, patients with skull base meningiomas had more deficits in memory components and long-term verbal and nonverbal memory than those with convexity meningiomas.…”

Section: Discussionsupporting

confidence: 93%

Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study

Liouta

Koutsarnakis

Liakos

et al. 2016

JNS

View full text Add to dashboard Cite

MeningioMas constitute approximately 15%-20% of all intracranial neoplasms and are often associated with favorable clinical prognosis because of their benign histology. Because of the high survival rates associated with meningiomas, patients with meningiomas can expect increased functional capacity compared with patients harboring other brain tumors. Parameters such as the rate of survival, tumor recurrence, and progression, 8 as well as the quality of life 3,17 of these patients, have traditionally been used to assess outcomes after intracranial meningioma surgery. According to recommendations from current outcomes research programs, neuropsychological-cognitive parameters also need to be incorporated to comprehensively evaluate surgical outcomes.Although meningiomas are extraaxial tumors, cognitive decline may arise due to perilesional edema and mass obJective Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. methods Patients with skull base (anterior and middle fossa) and convexity (anterior and posterior) meningiomas (n = 54) underwent neuropsychological examination prior to and 1 year after surgery. A control group (n = 52) of healthy volunteers matched for age, sex, and education underwent the same examination. Assessments included executive, memory, and motor functions with standardized testing. Patients with convexity meningiomas were clinically assessed for parietal association cortex functions. results All patients performed significantly worse (p < 0.05) in most neurocognitive domains than controls. The skull base group showed more disturbances in memory than the convexity group (p < 0.05). The anterior convexity group showed more deficits in executive function than the posterior convexity group, which presented with parietal association cortex deficits. Verbal deficits were more pronounced in the left hemisphere than in the right hemisphere. Patients with a large tumor (> 4 cm) had more severe neurocognitive deficits than those with a small tumor (< 4 cm). Postoperatively, patients showed no deterioration in neurocognitive function. Instead, significant improvement (p < 0.05) was observed in some executive, motor, and parietal association cortex functions. coNclusioNs According to the authors' findings, intracranial meningiomas may cause neurocognitive deficits in patients. Surgery does not cause a deterioration in cognitive function; instead, it may lead to improvements in some functions. Permanent neuropsychological postoperative deficits should be interpreted as tumor-induced rather than due to surgery.

show abstract

Section: Discussionsupporting

confidence: 93%

Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study

Liouta

Koutsarnakis

Liakos

et al. 2016

JNS

View full text Add to dashboard Cite

show abstract

“…This group includes few patients and these data deserves further investigation. Nonetheless data are in line with other studies showing improvements at follow-up in information processing speed and visuo-construction [8]. In addition data evidence oscillatory evolution of patients' performance, with immediate post-surgery worsening and improvements at follow-up, in line with other studies showing a mild decline 12-month after surgery, and a mild improvement slightly at an additional follow-up (before the 18 th month) [9].…”

Section: Discussionsupporting

confidence: 90%

“…This hypothesis is indeed in line with clinical indications showing improvements at follow-up. For instance, Habets et al [8] found significant improvements in information processing speed and visuo-construction at follow-up. Similarly, Correa et al [9] studied twenty-five low-grade glioma patients pre-surgery and at 6 and 12 months and found a mild decline 12-month after surgery, and a mild improvement slightly at an additional follow-up (before the 18 th month).…”

Section: Introductionmentioning

confidence: 99%

Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Tomasino

Marin

Madotto

et al. 2017

Int J Phys Med Rehabil

View full text Add to dashboard Cite

The five-point test (FPT) measures the ability to voluntarily generate non-verbal novel patterns. We investigated how this ability can be impaired or improved before immediately after brain surgery, and at follow-up. Twenty-two patients undergoing neurosurgery in the right hemisphere performed the FPT at T0 (pre-), T1 (1 week post-), and T2 (follow-up at 5 months after surgery). Significant improvements at T1 (in patients who had a deficit at T0) measured recovering (N=3/22); in addition there were patients who become pathological (8/22) and subjects who presented with the same degree of impairment as observed at T0 (stable, 1/22). Similarly, at T2 (4-5 months after surgery) we measured the effect of post-op reorganization: there were patients (5/22) who had been pathological at T1 and recovered at T2. Lesions overlapped in the right body of the corpus callosum/anterior cingulum reflecting the overcome of the deficit. Amelioration can be an effect of edema reduction. In addition, there were those who become pathological (4/22). Lesions overlapped in the right supramarginal gyrus. Lastly, there were subjects who presented with the same degree of impairment as observed at T1 (stable, 4/22) and those who remained spared (9/22). Multiple regression analysis was used to test if the number of strategies (CSs) used to solve the task or the perseverative behaviour (ErrI) significantly predicted participants' stratification, namely patients who worsened those who improved and patients who remained spared. It was found that the use of strategies significantly predicted participants' stratification, whereas perseverative behaviour was not a significant predictor.

show abstract

“…However, unlike the current study, in Habets et al's study (25), patients, who were unable to fully complete cognitive testing were clearly older and most of them were female (P = 0.009). There is significant evidence suggesting Rep Radiother Oncol.…”

Section: Discussioncontrasting

confidence: 80%

“…In addition, in the study of Habets et al (25), there was a significant correlation between age and cognitive function in patients after surgery.…”

Section: Discussionmentioning

confidence: 85%

Post-Treatment Neurocognitive Disorders in Adults with Frontal or Parietal Astrocytomas

Anvari

Salek

Fanipakdel

et al. 2016

Rep Radiother Oncol

View full text Add to dashboard Cite

Background: High-grade astrocytomas are among the most common neuroepithelial brain tumors. Because of their highly malignant nature, in most cases, in addition to maximal resection, they also require adjuvant treatments, such as chemotherapy and radiotherapy. A common accompanying condition, which may occur with this type of clinical presentation, is cognitive disorders. These can be caused by the tumor itself, the treatment used or may be patient related. The aim of this study was to evaluate the level of cognitive ability in patients with astrocytoma compared to the normal population and evaluating the factors possibly affecting them. Methods: A case-control study was performed on 30 adults referred to Imam Reza and Omid hospitals, Mashhad, Iran, during year 2014. The studied patients had astrocytomas, for which they had performed surgery. All patients had also received radiotherapy. The control group consisted of 30 healthy individuals, among the patients' family members, who were matched for age and gender with the patients. The tools used in this study were a checklist for demographic data, and the Farsi version of Addenbrook's cognitive questionnaire. Data were entered in the SPSS 22 software and analyzed using the Student's t test and Mann-Whitney test. P values of

show abstract

Tumour and surgery effects on cognitive functioning in high-grade glioma patients

Abstract: Tumour-related cognitive deficits are present in a majority of HGG patients preceding surgery. Surgery does not result in cognitive deterioration in the short term in most patients.

Cited by 106 publications

References 28 publications

Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study

Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study

Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Post-Treatment Neurocognitive Disorders in Adults with Frontal or Parietal Astrocytomas

Contact Info

Product

Resources

About