Tumour-associated antigens in systemic sclerosis patients with interstitial lung disease: association with lung involvement and cancer risk

Luca, Giacomo De; Bosello, Silvia Laura; Berardi, G.; Rucco, M.; Canestrari, Giorgia; Correra, M; Mirone, L.; Forni, Floreal H.; Mario, Clara Di; Danza, Francesco; Pirronti, Tommaso; Ferraccioli, Gianfranco

doi:10.1093/rheumatology/kev204

Cited by 25 publications

(26 citation statements)

References 34 publications

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“…B is classified as a Group 1 carcinogen to humans and animals by the International Agency for Research on Cancer (IARC), but its role in the development of cancer in scleroderma patients should be further investigated in other studies. Interestingly, patients with diffuse skin disease have a higher risk of cancer compared to other scleroderma patients and, as seen from our results, these patients are exposed to higher B concentrations [ 21 ].…”

Section: Discussionmentioning

confidence: 69%

Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study

Borghini

Poscia

Bosello

et al. 2017

IJERPH

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Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM10) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. A correlation study was conducted by enrolling 88 patients who suffer from SSc at the Fondazione Policlinico “A. Gemelli” in Rome (Italy) in the period from January 2013 to January 2014. The average mean concentrations of B (in 11 monitoring sites) and PM10 (in 14 sites) were calculated using data from the Regional Environmental Protection Agency’s monitoring stations located throughout the Lazio region (Italy) and then correlated with the clinical characteristics of the SSc patients. Of the study sample, 92.5% were female. The mean age was 55 ± 12.9 years old and the mean disease duration from the onset of Raynaud’s phenomenon was 13.0 ± 9.4 years. The Spearman’s correlation showed that concentrations of B correlate directly with the skin score (R = 0.3; p ≤ 0.05) and inversely with Diffusing Lung Carbon Monoxide (DLCO) results (R = −0.36; p = 0.04). This study suggests a possible role of B in the development of diffuse skin disease and in a worse progression of the lung manifestations of SSc.

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Section: Discussionmentioning

confidence: 69%

Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study

Borghini

Poscia

Bosello

et al. 2017

IJERPH

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“…36 In a study performed by Celeste et al 37 on 221 SSc patients, among which 168 with ILD, CA15-3 serum levels were found to correlate with the extent of fibrosis detected on HRCT as well as to be predictive for progression-free survival, with progression being defined by a decline in either FVC or DLCO. Supporting these data, De Luca et al 38 found that high CA15-3 levels were associated with lower FVC and higher interstitial and alveolar scores and were predictive for a short-term decline in lung function in 80 SSc-ILD patients. Despite the promising data, CA15-3 needs further systematic evaluation as a predictive biomarker, especially concerning its applicability in non-European cohorts.…”

Section: Surfactant Protein-dmentioning

confidence: 83%

Circulating biomarkers of systemic sclerosis – interstitial lung disease

Hoffmann‐Vold

Fretheim

Meier

et al. 2020

Journal of Scleroderma and Related Disorders

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Interstitial lung disease is a frequent organ manifestation in systemic sclerosis and is associated with high mortality. It is crucial to diagnose interstitial lung disease in systemic sclerosis and to assess severity and identify patients prone to progression at an early stage to ultimately decrease organ damage and improve outcome. Circulating anti-topoisomerase-I autoantibodies have long been associated with the presence and development of systemic sclerosis – interstitial lung disease, evidence on their potential to further predict the clinical course of systemic sclerosis is however conflicting. C-reactive protein is a marker of infection and systemic inflammation with widespread clinical application and is elevated in systemic sclerosis with a tendency towards higher abundancy in patients with early disease. The role of other circulating biomarkers is promising but hampered by the lack of standardized criteria and guidelines for sample/data collection, analyses, reporting and validation and has not reached prime time for clinical application. However, epithelial markers including Krebs von den Lungen-6 and surfactant protein D and several cytokines and chemokines including CCL2 and CCL18 for severity assessment of systemic sclerosis – interstitial lung disease patients at the time of interstitial lung disease diagnosis and to predict interstitial lung disease progression have been reported and seem to be promising candidate biomarkers in the future.

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“…SSc ve SLE akciğer tutulumunda CA-15-3 seviyesinin arttiği gösterilmiştir [4,5]. Yapilan bir çalişmada serum CA15-3 seviyesinin poliartrit, ANA pozitifliği ve serum CRP düzeyleri ile ilişkili olduğu gösterilmiştir [5].Serum CA-15-3 seviyesi, idiyopatik pulmoner fibrozis/ interstisyel pnömoni tanili hastalarda yüksek bulunabilir [9]. Bir çalişmada SSc-intersitisyel akciğer hastaliğinda biyolojik belirteç olarak CA-15-3'ün olasi rolü üzerinde durulmuştur.…”

Section: Discussionunclassified

“…Bu belirteç, akciğer hasarinin derecesini belirlemede ve akciğer tutulumunun prognozunda klinik olarak anlamli değişikliklerin gösterilmesinde iyi bir özgüllük ve duyarlilik sunmuştur [10]. İnterstisyel akciğer hastaliği olan SSc tanili hastalarda serum CA-15-3 seviyeleri ile yüksek çözünürlüklü BT puanlamasi arasinda güçlü bir korelasyonolduğu bulunmuştur [9,10].…”

Section: Discussionunclassified

Increased serum tumor markers in a patient with rheumatoid arthritis

Bayğın¹,

Sargın²,

Şentürk³

et al. 2017

Pau Med J

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ÖzetTümör ilişkili antijenler, malignitelerde takip ve tedaviye yanitin değerlendirilmesinde kullanilir. Antijenler inflamatuar hücreler tarafindan eksprese edilebilir ve malin hücrelerin adezyon ve metastazlarinda önemli rol oynabilir. İnflamatuar romatizmal hastaliklarin akciğer tutulumu ve plevral effüzyonu bulunan hastalarda tümör ilişkili antijen seviyelerinin arttiği rapor edilmiştir. Biz, RA tanili bir kadin hastada tümör belirteçleri ile hastalik aktivitesi arasindaki ilişkiyi sunmayi amaçladik. Bir yildan beri RA tanisi olan 61 yaşinda kadin hasta, sağ dizde, her iki el bileğinde ve metakarpofalangeal eklemlerde şişlik ve hassasiyet olmasi nedeniyle kliniğimize başvurdu. Özgeçmişinde leflunomid 20 mg/gün ve sulfasalazin 2 gr/gün kullanimi dişinda bir özellik yoktu. Fizik muayenede bilateral akciğer alt zonda raller mevcuttu. Hastanin laboratuvar verileri: hastalik aktivite skoru : 6,02, eritrosit sedimentasyon hizi [ESH]: 72 mm/h, CRP: 37,95 mg/l, romatoid faktör: 48,5 IU/ml, anti-CCP: 67,1 U/ml, CA19-9: 410,67 U/ml [0-37 U/ml], CA-125: 197,1 U/ml [0-35 U/ml] ve CA-15-3: 51,6 U/ml [0-31,3 U/ml] idi. Postero-anterior akciğer grafisinde bilateral orta ve alt zonlarda retiküler dansite artişi ve toraks BT'de her iki akciğerde retiküler, buzlu cam opasiteleri ve ince bal peteği değişiklikleri görüldü. Malignite lehine herhangi bir kanit yoktu ve aktif hastaliği olan hastaya anti-inflamatuar tedavi verildi. Takiplerde, ESH, CRP, DAS-28, CA19-9, CA-125 ve CA15-3 düzeyleri geriledi. RA' da hastalik aktivitesini, organ hasarini ve tedaviye yaniti belirlemek için ideal biyobelirteçlere ihtiyaç vardir. Bağ doku hastaliklarinda organ tutulumu ile tümör belirteçleri arasindaki ilişki nedeniyle, bu biyobelirteçler hastalik progresyonu ve tedaviye yanitin değerlendirilmesinde yardimci olabilir. Tümör belirteçleri, malignite ekarte edildikten sonra, RA hastalarinda (özellikle akciğer tutulumlu) hastalik aktivitesinin değerlendirilmesinde kullanilabilir. Pam Tıp Derg 2017;10(1):81-85Anahtar sözcükler: Romatoid artrit, tümor belirteçleri, hastalik aktivitesi. AbstractTumor-associated antigens are used to assess the response to treatment and follow-up of malignancies.They may be expressed by inflammatory cells, and play an important role in the adhesion and metastasis of malignant cells. Increased level of tumor associated antigens were reported in patients with pleural effusion and pulmonary involvement of inflammatory rheumatic diseases.We aimed to present the relationship between tumor markers and disease activity in a female patient diagnosed with RA.61-year-old female patients diagnosed with RA since one year was admitted to our clinic with the tenderness and swelling of her right knee, both wrists and metacarpophalangeal joints. She had no medical history, except for taking leflunomide 20 mg/day and sulfasalazine 2 g/day.Physical examination revealed bilateral pulmonary crackles in the lower zone. The laboratory findings of the patients were as follows: Disease activity score was 6.02,erythrocyte sedimentation rat...

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Tumour-associated antigens in systemic sclerosis patients with interstitial lung disease: association with lung involvement and cancer risk

Abstract: TAAs can be elevated in the sera of SSc patients and correlate with the degree of lung damage, suggesting a role as severity biomarkers. Close follow-up is necessary in SSc patients because of the increased cancer risk overall in patients with increased TAAs.

Cited by 25 publications

References 34 publications

Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study

Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study

Circulating biomarkers of systemic sclerosis – interstitial lung disease

Increased serum tumor markers in a patient with rheumatoid arthritis

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