Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer

Hamm, Alexander; Prenen, Hans; Delm, Wouter Van; Matteo, Mario Di; Wenes, Mathias; Delamarre, Estelle; Schmidt, Thomas; Weitz, Jürgen; Sarmiento, Roberta; Dezi, Angelo; Gasparini, Giampietro; Rothé, Françoise; Schmitz, Robin; D’Hoore, André; Iserentant, Hannes; Hendlisz, Alain; Mazzone, Massimiliano

doi:10.1136/gutjnl-2014-308988

Cited by 73 publications

(78 citation statements)

References 29 publications

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“…A case-control study characterized peripheral blood monocyte samples from 360 CRC patients at four European oncology centers. Their results suggest that tumor-educated circulating monocytes could be used as a biomarker in CRC diagnosis, and potentially also for follow-up and therapeutic monitoring [23]. Furthermore, the presence of TAMs in the tumor stroma was correlated with poor survival in CRC patients, but the opposite correlation was found if TAMs were at the tumor front.…”

Section: Dual Role Of Tams In Crcmentioning

confidence: 99%

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Zhong¹,

Chen²,

Yang³

2018

Cell Physiol Biochem

109

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Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment, and they play a pivotal role in prompting the various tumor growth. However, the role of TAMs in colorectal carcinoma (CRC) is controversial, because a few papers report that TAMs is beneficial to CRC patients. In this review, we discuss the good or bad roles of TAMs in CRC progression. Interestingly, recent studies provide strong evidence that TAMs facilitate CRC growth, but do not exert tumor suppressive activities. TAMs can stimulate CRC growth by altering extracellular matrix remodeling, tumor metabolism, angiogenesis, as well as the tumor microenvironment. Therefore, TAMs could serve as a target for CRC therapeutic treatment.

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Section: Dual Role Of Tams In Crcmentioning

confidence: 99%

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Zhong¹,

Chen²,

Yang³

2018

Cell Physiol Biochem

109

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“…For example, in patients with stage III colon cancer, a higher lymphocyte to monocyte ratio was associated with increased time to recurrence and overall survival . In colorectal cancer patients, peripheral blood monocytes display a gene signature that is not present in healthy monocytes or other types of cancer, highlighting the potential for cancer‐specific biomarkers based on monocyte signatures …”

Section: Targeting Of Monocytes For Cancer Diagnostics and Therapymentioning

confidence: 99%

“…115 In colorectal cancer patients, peripheral blood monocytes display a gene signature that is not present in healthy monocytes or other types of cancer, highlighting the potential for cancer-specific biomarkers based on monocyte signatures. 63 Discrimination of monocyte subsets may provide additional diagnostic power and biological insights given the divergent roles of different monocyte subsets in cancer progression. A lower frequency of peripheral blood CD14 + CD16monocytes was associated with their increase in bone marrow and greater survival in pancreatic cancer, 76 suggesting that pancreatic tumors systemically alter monocyte trafficking.…”

Section: Monocytes As Cancer Diagnosticsmentioning

confidence: 99%

Monocyte heterogeneity and functions in cancer

Olingy

Dinh

Hedrick

2019

Journal of Leukocyte Biology

416

310

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Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro‐ and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor‐associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte‐targeted therapeutic strategies for cancer treatment.

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“…Previous investigations have shown that some gene expressions in peripheral blood mononuclear cells (PBMCs) from breast cancer patients are correlated with circulating tumor cells, tumor grade and formation of metastasis . The changes of gene expression profiles in PBMCs, in response to factors released by cancer cells, are reversible and specific to tissue types of cancers such as prostate cancer, breast cancer, lung cancer and colorectal cancer . A recent study has demonstrated that the gene expression level of the calcium‐activated chloride channel (CaCC) ANO1 in PBMCs is highly correlated with tumor size and differentiation of gastrointestinal stromal tumors (GIST), whereas most patients with GIST become ANO1‐negative after surgery or decline of ANO1 expression level in response to imatinib treatment .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Ca²⁺‐activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling

Liu

Zhang

Hou

et al. 2019

Intl Journal of Cancer

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Most common ovarian cancers are epithelial carcinoma in which the etiology for carcinogenesis remains elusive. ANO1/TMEM16A, a member of Ca 2+ -activated Cl − channels (CaCCs), has been demonstrated to promote epithelium-originated cancers and whether it plays a role in the pathogenesis of ovarian cancer is unknown. In our study we found that ANO1 proteins were overexpressed in human epithelial ovarian cancer cells and tissue samples. ANO1 protein upregulation was correlated with the clinical FIGO (International Federation of Gynecology and Obstetrics) staging and poor grade in ovarian cancer tissues. Interestingly, the upregulation of ANO1 gene expression was also detected in the peripheral blood mononuclear cells (PBMCs) from preoperative patients with ovarian tumors, and the down-regulation of ANO1 in the PBMCs from postoperative patients. Silencing of ANO1 inhibited proliferation and invasion of ovarian cancer cells. Mechanistically, ANO1 knockdown attenuated phosphorylation of PI3K/ Akt, and inhibition of PI3K/Akt signaling by specific inhibitor LY294002 resulted in suppression of ovarian cancer cells growth promoted by ANO1 expression. Furthermore, intratumoral injection of ANO1 siRNA suppressed subcutaneous xenograft tumor growth in nude mice implanted with ovarian cancer SKOV3 cells. Taken together, our findings demonstrate that ANO1 overexpression is involved in the pathogenesis of human epithelial ovarian cancer. Inhibition of ANO1 upregulation or inactivating PI3K/Akt signaling may have therapeutic potential for epithelial ovarian cancer, and the detection of ANO1 expression level in PBMCs from patients may also serve as a biomarker for diagnosis and prognosis of epithelial ovarian cancers.

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Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer

Cited by 73 publications

References 29 publications

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Monocyte heterogeneity and functions in cancer

Inhibition of Ca²⁺‐activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling

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Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer

Cited by 73 publications

References 29 publications

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Monocyte heterogeneity and functions in cancer

Inhibition of Ca2+‐activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling

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Inhibition of Ca²⁺‐activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling