Tumour necrosis factor‐alpha gene polymorphisms and susceptibility to oral lichen planus

Abstract

TNF-α-308AA may play a relevant role in the susceptibility and severity of OLP in the Thai population. However, further investigation of this study is needed.

Association between -308 G/A polymorphism in TNF-α gene and lichen planus: A meta-analysis

“…1 study was performed among LP patients [19], while 7 were performed in OLP patients [20][21][22][23]. Of all the OLP patients, 3 studies referred to both eOLP and neOLP [21,23]. 1 study was specifically performed in patients of HCV positive infection [20], 3 were of negative HCV infection [20,21], and 4 were in mixed (studied population with or without HCV infection or HCV information not mentioned) HCV infection status [19,22,23].…”

“…Among 9 comparisons, 1 comparison in 1 article was excluded for data overlapped [18]. Finally, a total of 8 comparisons in 5 articles were identified for meta-analysis [19][20][21][22][23]. The characteristics of each comparison including authors and published years, country, ethnicity of the study populations, subtypes of LP and OLP, genotyping method and the numbers of cases and controls of each study are listed in Table 1.…”

“…The characteristics of each comparison including authors and published years, country, ethnicity of the study populations, subtypes of LP and OLP, genotyping method and the numbers of cases and controls of each study are listed in Table 1. There were 4 comparisons were performed in Asians [21,23], 3 were in Caucasians [19,20], and 1 20 resu lts id enƟfi ed from Pubm ed, Emb ase and CNKI d atab ases aŌer a n iniƟal search 12 were excl uded for: Not rel evant to lich en plan us and pol ymorphi sm Revi ews 8 potenƟal arƟcles concernin g the current topic for full -text vi ew 2 were exclud ed for n ot rel evant to TNF -α po lymorphism 9 com pari sons in 6 arƟcles rel evant to TNF-α po lymorphi sm and lich en pl anus were for dat a extrac Ɵon 1 com pari son in 1 arƟcle was exclud ed for d ata overlapp ed Finally, 8 comparisons in 5 arƟcles inve sƟgaƟng associ aƟon between poly morphi sm in TNF-α gene and lichen pl anus were ide nƟfi ed was in mixed (mixed with different ethnic populations or ethnic information were not mentioned) ethnic populations [22]. 1 study was performed among LP patients [19], while 7 were performed in OLP patients [20][21][22][23].…”

“…However, the conclusions were conflicting and incomplete. For example, Carrozzo et al [18,20], Kimkong et al [23] and Xavier et al [22] suggested that TNF-a polymorphisms seem to have some influence on the susceptibility and progression of OLP, whereas Krasowska et al [19] did not find any correlation between genotype distribution, allele frequency and lichen planus. No definitive assumption can be drawn based on one single study; hence, we adopted a meta-analysis of all qualified studies to draw a more precise estimation of the genetic associations of the TNF-a-308(rs1800629) polymorphism with lichen planus.…”

“…A G ! A polymorphism at position -308 of the TNF-a gene promoter may increase TNF-a transcription and TNF-a production in vitro [13,15-of LP [18][19][20][21][22][23]. However, the conclusions were conflicting and incomplete.…”