Tumour necrosis factor G-308A polymorphism modifies the effect of home dampness on childhood asthma

Tsai, Chien‐Hsiung; Tung, Kuan-Yen; Chen, Chang-Hao; Lee, Yungling Leo

doi:10.1136/oem.2010.060970

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…The inflammatory response gene TNF (rs1800629) has been reported to modify the relationship between ozone and asthma (Yang et al 2008) and indoor home dampness and asthma (Tsai et al 2011); however, similar to our results, no effect modification was noted in the association between traffic-related NO 2 and adult-onset asthma (Castro-Giner et al 2009). …”

Section: Discussionsupporting

confidence: 82%

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

MacIntyre

Bräuer

Melén

et al. 2014

Environ Health Perspect

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Background: Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma.Objective: Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood asthma.Methods: Traffic-related air pollution, asthma, wheeze, gene variant, and potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma and wheeze from birth to 7–8 years of age (confirmed by pediatric allergist in two cohorts). Individual estimates of annual average air pollution [nitrogen dioxide (NO2), particulate matter ≤ 2.5 μm (PM2.5), PM2.5 absorbance, ozone] were assigned to each child’s birth address using land use regression, atmospheric modeling, and ambient monitoring data. Effect modification by variants in GSTP1 (rs1138272/Ala114Val and rs1695/IIe105Val) and TNF (rs1800629/G-308A) was investigated.Results: Data on asthma, wheeze, potential confounders, at least one SNP of interest, and NO2 were available for 5,115 children. GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. In relation to air pollution exposure, children with one or more GSTP1 rs1138272 minor allele were at increased risk of current asthma [odds ratio (OR) = 2.59; 95% CI: 1.43, 4.68 per 10 μg/m3 NO2] and ever asthma (OR = 1.64; 95% CI: 1.06, 2.53) compared with homozygous major allele carriers (OR = 0.95; 95% CI: 0.68, 1.32 for current and OR = 1.20; 95% CI: 0.98, 1.48 for ever asthma; Bonferroni-corrected interaction p = 0.04 and 0.01, respectively). Similarly, for GSTP1 rs1695, associations between NO2 and current and ever asthma had ORs of 1.43 (95% CI: 1.03, 1.98) and 1.36 (95% CI: 1.08, 1.70), respectively, for minor allele carriers compared with ORs of 0.82 (95% CI: 0.52, 1.32) and 1.12 (95% CI: 0.84, 1.49) for homozygous major allele carriers (Bonferroni-corrected interaction p-values 0.48 and 0.09). There were no clear differences by TNF genotype.Conclusions: Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution.Citation: MacIntyre EA, Brauer M, Melén E, Bauer CP, Bauer M, Berdel D, Bergström A, Brunekreef B, Chan-Yeung M, Klümper C, Fuertes E, Gehring U, Gref A, Heinrich J, Herbarth O, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Postma DS, Thiering E, Tiesler CM, Carlsten C, TAG Study Group. 2014. GSTP1 and TNF gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) Study. Environ Health Perspect 122:418–424; http://dx.doi.org/10.1289/ehp.1307459

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Section: Discussionsupporting

confidence: 82%

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

MacIntyre

Bräuer

Melén

et al. 2014

Environ Health Perspect

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“…Exposure to other allergens such as mites is also associated with childhood asthma and can modify the risk of childhood asthma associated with TRAP [48]. Other environmental exposures such as prenatal smoke exposure, home dampness, and prenatal acetaminophen use can modify the association of genetic risk factors with childhood asthma onset [49–51].…”

Section: Discussionmentioning

confidence: 99%

Association between Traffic Related Air Pollution and the Development of Asthma Phenotypes in Children: A Systematic Review

Lau

Norman

Smith

et al. 2018

International Journal of Chronic Diseases

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Introduction Traffic related air pollution (TRAP) has long been associated with the onset of childhood asthma. The relationship between TRAP exposure and the development of childhood asthma phenotypes is less understood. To better understand this relationship, we performed a systematic review of the literature studying childhood TRAP exposure and the development of childhood asthma and wheezing phenotypes (transient, persistent, and late-onset asthma/wheezing phenotypes). Methods A literature search was performed in PubMed, Embase, and Scopus databases for current literature, returning 1706 unique articles. After screening and selection, 7 articles were included in the final review. Due to the low number of articles, no meta-analysis was performed. Results TRAP exposure appears to be associated with both transient and persistent asthma/wheezing phenotypes. However, there was little evidence to suggest a relationship between TRAP exposure and late-onset asthma/wheezing. The differing results may be in part due to the heterogeneity in study methods and asthma/wheezing phenotype definitions, in addition to other factors such as genetics. Conclusion TRAP exposure may be associated with transient and persistent asthma/wheezing phenotypes in children. The low number of studies and differing results suggest that further studies are warranted.

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“…2 Molds in the wall can release spores into the air, 6 and strong associations (odds ratio, OR > 1) have been found between indoor visible molds or mold odor and children asthma, wheeze, and rhinitis in China. [7][8][9][10][11][12] Conventional bacteria and fungi sampling approach is field sampling and offline laboratory analysis. 13 The sampling method includes impaction, impingement, filtration, electrostatic precipitation, gravity sampling, and cyclone; enumeration method includes cultivation and non-cultivation.…”

Section: Introductionmentioning

confidence: 99%

Indoor exposure levels of bacteria and fungi in residences, schools, and offices in China: A systematic review

et al. 2020

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Microbes in buildings have attracted extensive attention from both the research community and the general public due to their close relationship with human health. However, there still lacks comprehensive information on the indoor exposure level of microbes in China. This study systematically reviews exposure levels, the community structures, and the impact factors of airborne bacteria and fungi in residences, schools, and offices in China. We reviewed the major literature databases between 1980 and 2019 and selected 55 original studies based on a set of criteria. Results show that the concentration of indoor bacteria varies from 72.5 to 7500 CFU/m 3 , with a median value of 1000 CFU/m 3 , and the concentration of fungi varies from 12 to 9730 CFU/m 3 , with a median value of 526 CFU/m 3. The concentration level of microbes varies in different climate zones, with higher bacterial concentrations in the severe cold zone, and higher fungal concentrations in the hot summer and warm winter zone. Among different buildings, classrooms have the highest average bacteria and fungi levels. This review reveals that a unified assessment system based on health effects is needed for evaluating the exposure levels of bacteria and fungi.

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Tumour necrosis factor G-308A polymorphism modifies the effect of home dampness on childhood asthma

Abstract: Home dampness is a risk factor for asthma and wheeze among children, especially for those with the TNF-308 A allele.

Cited by 16 publications

References 41 publications

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

Association between Traffic Related Air Pollution and the Development of Asthma Phenotypes in Children: A Systematic Review

Indoor exposure levels of bacteria and fungi in residences, schools, and offices in China: A systematic review

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