Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice

Babu, B. Hari; Shylesh, B.S; Padikkala, José

doi:10.1016/s0378-8741(01)00347-6

Cited by 66 publications

(55 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have received wide attention in recent years due to their diverse pharmacological activities including cytotoxic and cancer chemopreventive effects (Babu et al 2002). Flavonoids, such as curcumin, genistein, quercetin, luteolin, kaempferol etc., are known to have cell line specific antiproliferative and apoptosis inducing activity (Ren et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and apoptotic activities of extract of Amaranthus spinosus L. in Allium cepa and human erythrocytes

Prajitha

Thoppil

2016

Cytotechnology

View full text Add to dashboard Cite

The present study examined the apoptosis inducing effects of Amaranthus spinosus L. aqueous extract in Allium cepa root meristematic cells and human erythrocytes. Cytogenetic assay revealed many apoptosis inducing cytogenetic aberrations viz., cytoplasmic breakage, cytoplasmic disintegration, cytoplasmic shrinkage, receding of cytoplasm, cytoplasmic vacuolation, enucleated cell, ghost cell, nuclear vacuolation, nuclear fragmentation and nuclear disintegration. A remarkable modification of red blood cell surface morphology was observed in the result of RBC assay. The treated RBCs show membrane blebbing and shrinkage, features typical for apoptosis in nucleated cells. Significant induction of cell death was observed in treated Allium root tip cells after Evans blue staining, disclosing the membrane damage potential of the plant extract. TTC assay results in reduced mitochondrial/ metabolic activity in Allium root tip cells after treatment, designating the adverse effect of plant extract on mitochondrial respiratory chain. These results confirm the apoptosis inducing potential of A. spinosus extract. Confirming the present results by further in vitro studies, it can be effectively targeted against cell proliferation during cancer treatment by inducing apoptosis. Thus from the present investigation it can be concluded that the aqueous extract of A. spinosus exhibited apoptosis induction and cytotoxic activities.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytotoxic and apoptotic activities of extract of Amaranthus spinosus L. in Allium cepa and human erythrocytes

Prajitha

Thoppil

2016

Cytotechnology

View full text Add to dashboard Cite

show abstract

“…triterpenoids, alkaloids, phenolic compounds, lignan, flavonoid, steroids, and terpenoids [21] . The leaf, root, stem, and bark of A. ilicifolius have been reported to be able to prevent tumor growth and cancer progression [22,23] . In order to intensively explore the potency of A. ilicifolius for cancer medication, the study of antioxidant and cytotoxic activity of A. ilicifolius flower was undertaken.…”

Section: Commentsmentioning

confidence: 99%

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Firdaus

Prihanto

Nurdiani

2013

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Moreover, the antioxidant activity of the fractions and isolated compounds of the plant has also been reported [58][59][60].…”

Section: Antioxidant Activitymentioning

confidence: 94%

“…This study revealed that A. ilicifolius has significant bioactivities like, antioxidant and cytotoxic activity [26,55], antinociceptive activity [56], anti-inflammatory activity [23,26], anti-osteoporotic activity [57], hepatoprotective activity [26,58], chemopreventive activity [21]; leishmanicidal, tumour reducing and anticancer activities [26,58,59,60]; antileishmanial, antiulcer, antimicrobial, and osteoblastic, activities [26]. Moreover, Firdaus et al found in their study that flower extract of the plant also has good cytotoxic effects [40]; Smitha et al showed the anticancer activity of ethyl acetate extract of on two cell lines PA-1 and MCF-7 [61].…”

Section: Compound Isolationmentioning

confidence: 99%

Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

Bora

Adhikari

Das

et al. 2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Acanthus (family Acanthaceae) is a genus of the major group angiosperms (flowering plants) comprising more than 29 species widely distributed in the tropical and subtropical region. The aim of this review is to offer thorough scientific information on ethnomedicinal uses, phytochemical, and pharmacological activities of the plant species belonging to the genus Acanthus. Numerous traditional uses of the genus have been supported in this article from the results, and executed by the extracts and/or pure compounds obtained from pharmacological studies will provide a single platform to help future researches on the genus Acanthus. Furthermore, ethnomedicinal evaluation using fractions or isolation of medicinal principles was extensively explored by databases like Google, Google Scholar, and Science Direct at the same time.

show abstract

Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice

Cited by 66 publications

References 8 publications

Cytotoxic and apoptotic activities of extract of Amaranthus spinosus L. in Allium cepa and human erythrocytes

Cytotoxic and apoptotic activities of extract of Amaranthus spinosus L. in Allium cepa and human erythrocytes

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

Contact Info

Product

Resources

About