Tumour regression and relapse in mice inoculated with murine sarcoma virus (Moloney)

Abstract

The oncogenic effect of the virus was tested in mice of different strains and ages. Local sarcomas were induced in all mice, although strain, age or dose dependent variations were found. 4 forms of development occurred: progressive lethal; lethal but long persistent; complete tumour regression; tumour recurrence after regression. Virus activity was highest in the progressively-growing and in the recurrent tumours, while in the longpersistent tumours or in tissue at the site of regressed tumours, little or no virus could be detected. TUMOR REGRESSION UNO RUCKFALL IN MAUSEN, DIE MIT MURINE SARCOMA VIRUS (MOLONEY) GEIMPFT SIND Die onkogenische Wirkung des Virus wurde in Mausen verschiedener SHimme und verschiedenen Alters gepriift. Lokale Sarkome wurden in allen Mausen hervorgerufen, obgleich Unterschiede, von Stamm, Alter und Dosis abhangig, gefunden wurden. Es gab 4 Arten der Entwicklung: Progressiv lethal; lethal, aber lange-persistent; v611ige Tumorregression; Wiederauftreten des Tumors nach Regression. Virus Aktivitat war am Starksten in den progressiv wachsenden und in den wiederauftretenden Tumoren, wahrend in den lange-persistenten Tumoren oder in Geweben an Stelle von ri.'lckgebildeten Tumoren wenig oder kein Virus entdeckt werden konnte. REGRESSION DES TUMEURS ET RECHUTE DANS LES SOURIS VACCINEES AVEC MURINE SARCOMA VIRUS (MOLONEY)L'effet oncologique du virus fut examine dans des souris de souches et d'ages differents. Des sarcomes locals furent induits dans toutes les souris, bien qu'il y avait des variations selon les souches, l'age et la dose. 4 formes de developpement furent observees: progressive lethale; lethale mais longuement persistante; regression totale des tumeurs; tumeur

Some pathogenic aspects of murine sarcoma virus (Moloney) in rats

“…In weanling or adult mice inoculated with MSV (M), the murine sarcoma virus of Moloney, a high incidence of complete regression of the local tumour is a common finding (Blumenschein & Moloney, 1969;Fefer, McCoy, Perk & Glynn, 1968;Gazdar, 1970;Law, Ting & Stanton, 1970;Perk, Russell, Smith & Moloney, 1973), although it may reappear later as welLas new growths developing at unrelated sites. In rats, however, there seems to be no report of spontaneous regression and relapse of such primary tumours.…”