Tunable electron beam pulser for picoseconds stroboscopic microscopy in transmission electron microscopes

Jing, Chunguang; Zhu, Yimei; Liu, Ao; Schliep, Karl B.; Fu, Xuewen; Zhao, Yunsong; Montgomery, Eric; Rush, Wade; Kanareykin, A.; Katz, Michael B.; Lau, June W.

doi:10.1016/j.ultramic.2019.112829

Cited by 29 publications

(11 citation statements)

References 13 publications

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“…In the past few years, laser-free UTEM has been developed, alleviating the laser requirements by employing radiofrequency (RF) modulation of the TEM's source beam. High-frequency (GHz) beam pulses have been demonstrated using a resonant deflecting cavity [19][20][21] and a traveling wave stripline [6,22] design. The resonant deflecting cavity is a fixed frequency RF device, thereby fixing the beam modulation rate.…”

Section: Rf (Laser-free) Utemmentioning

confidence: 99%

Ultrafast Transmission Electron Microscopy: Techniques and Applications

2021

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Abstract:With the growing applications of temporally resolved electron microscopy for probing basic phenomena and reducing beam-induced damage, a multifaceted introduction to the field of ultrafast transmission electron microscopy is provided. This primer includes techniques and equipment as well as implementation perspectives. Historical developments and recent technical advances will provide insight into ultrafast capabilities for research as well as educate electron microscopists on the general techniques. This technology review also includes applications enabled by ultrafast techniques using various sample stimuli from multidisciplinary fields.

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Section: Rf (Laser-free) Utemmentioning

confidence: 99%

Ultrafast Transmission Electron Microscopy: Techniques and Applications

2021

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“…Techlabs pulser 19,20 : a STROBO-200 on a JEOL JEM-2010F at Brookhaven National Laboratory (BNL), and a STROBO-300 on a JEOL JEM-3010 at the National Institute of Standards and Technology (NIST) 21 . Each operates at fixed beam energy: 200 and 300 keV respectively.…”

Section: Fig 1a Illustrates a Pulsed Electron Beam Generated By The Nmentioning

confidence: 99%

Mitigation of radiation damage in biological macromolecules via tunable picosecond pulsed transmission electron microscopy

Choe

Пономарев

Montgomery

et al. 2020

Preprint

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We report mitigation of electron-beam-induced radiation damage in biological macromolecules using rapid, low-dose transmission electron microscopy (TEM) with a new, tunable, retrofittable stroboscopic pulser. Damage mitigation strategies historically consisted of sample cryoprotection and ultra-low beam current; ultrafast laser-pulsed systems have shown promise, but with day-long acquisition times. We show the first practical, fast, laser-free tunable system, with acquisition of diffraction series in minutes at 5.2 GHz and 10 pA. This is the largest study to date: two materials (C 36 H 74 paraffin and purple membrane), two beam energies (200 keV and 300 keV), two independent microscopes (Schottky and LaB 6 ), two modes (pulsed and continuous), and unsurpassed repetition rate tunability. Critical dose at room temperature doubled versus continuous beam for~100 MHz single-electron repetition rates. Results herald a new class of highly-tunable, ultrafast pulsers with future applications in cryogenic electron microscopy (CryoEM), high resolution single particle imaging, and rapid low-dose TEM.

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“…Xuewen Fu 1 , Myung-Geun Han 1 , Chunguang Jing 2 , Ao Liu 2 , Eric Montgomery 3 , K. Schliep 3 , June Lau 3 and Yimei Zhu 1 1 Brookhaven National Laboratory, Upton, New York, United States, 2 Euclid Techlabs LLC, Bolingbrook, Illinois, United States, 3 National Institute of Standards and Technology, Gaithersburg, Maryland, United States Ultrafast electron microscopy has been identified by DOE/BES as one of the major research priority directions. It provides tremendous research opportunities but has many challenges for science and technology.…”

Section: -Visualizing Hidden States and Spin Dynamics Using Ultrafastmentioning

confidence: 99%

Visualizing Hidden States and Spin Dynamics Using Ultrafast Electron Phase Microscopy

Fu¹,

Han²,

Jing³

et al. 2020

Microsc Microanal

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Tunable electron beam pulser for picoseconds stroboscopic microscopy in transmission electron microscopes

Cited by 29 publications

References 13 publications

Ultrafast Transmission Electron Microscopy: Techniques and Applications

Ultrafast Transmission Electron Microscopy: Techniques and Applications

Mitigation of radiation damage in biological macromolecules via tunable picosecond pulsed transmission electron microscopy

Visualizing Hidden States and Spin Dynamics Using Ultrafast Electron Phase Microscopy

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