Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System

Ha, Wei; Yu, Jing; Song, Xinyue; Chen, Juan; Shi, Yan‐Ping

doi:10.1021/am5022864

Cited by 90 publications

(80 citation statements)

References 58 publications

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“…Partial inclusion of PEG chains and hydrophobic aggregation of CPT ends resulted into stable gels, which could also incorporate other hydrophilic antitumor agents (such as 5-fluorouracil). 96 These gels showed temperature-tunable controlled release of both drugs On-demand gel-sol transitions can be obtained as a function of temperature, regulating PEG chain length and αCD concentration. Reprinted with permission from Ha et al 96 Copyright 2014 American Chemical Society.…”

Section: Cyclodextrin-based Poly(pseudo)rotaxanesmentioning

confidence: 95%

“…96 These gels showed temperature-tunable controlled release of both drugs On-demand gel-sol transitions can be obtained as a function of temperature, regulating PEG chain length and αCD concentration. Reprinted with permission from Ha et al 96 Copyright 2014 American Chemical Society. 10 Sustained release of proteins and gene material is also receiving an increasing attention.…”

Section: Cyclodextrin-based Poly(pseudo)rotaxanesmentioning

confidence: 95%

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Supramolecular cyclodextrin-based drug nanocarriers

2015

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Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances. CDs can perform as multifunctionalizable cores to which very diverse (macro)molecules and drugs can be conjugated. Grafting with amphiphilic molecules can lead to nanoassemblies exhibiting a variety of architectures. CDs can also polymerize with other CDs or can be used to functionalize preexisting polymers to form polymers/networks with enhanced capability to form inclusion complexes. Alternatively, CDs can be exploited as transient cross-linkers to form poly(pseudo)rotaxane-based networks or zipper-like assemblies. Combination of mutifunctionality and complexation ability of CDs has been shown to be useful to develop depot-like formulations and colloidal nanocarriers with improved performances regarding easiness of administration, protection of the encapsulated substances, control of the delivery rate, and cell interactions. The aim of this review is to provide an overall view of the diversity of designs of CD-based supramolecular nanosystems with a special focus on the advances materialized in the last five years, including clinical trials.

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Section: Cyclodextrin-based Poly(pseudo)rotaxanesmentioning

confidence: 95%

Section: Cyclodextrin-based Poly(pseudo)rotaxanesmentioning

confidence: 95%

Supramolecular cyclodextrin-based drug nanocarriers

2015

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“…Ha et al 108 proposed a PEG-based hydrogel as a codelivery system. The length of the PEG chains and cyclodextrin ( α CDs) acted as transition temperature-determining factors.…”

Section: Miscellaneous Temperature-responsive Nanocarriersmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

353

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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“…Generally, the low-molecular-weight hydrogel is considered hydrophilic and suitable candidate for hydrophilic drug delivery. Ha etc conjugated CPT molecule to a class of low-molecular-weight poly-(ethylene glycol) (PEG) chains (MW = 500, 1000, and 2000), producing an amphiphilic prodrug (62). The CPT-PEG conjugate formed stable hydrogels and could be loaded with water-soluble drug 5-fluorouracil (5-FU).…”

Section: Nanoparticles For Combined Drug Delivery With Camptothecinmentioning

confidence: 99%

Nanosized Camptothecin Conjugates for Single and Combined Drug Delivery

Chen¹,

Sun²,

Wang³

et al. 2016

Eur J Bio Med Res

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Camptothecin (CPT), a natural DNA topoisomerase 1 inhibitor, is commonly used as a model hydrophobic compound for anticancer drug delivery research. Nanoparticle loaded with active drugs has the potential to selectively deliver the therapeutic agents into tumor cells without affecting the normal tissues, and hence is attracting tremendous attention from biomedical scientists. Nanoparticles can benefit from the enhanced permeability and retention effect (EPR) of the tumor tissues that allows nanoparticles to be transported through the leaky blood vessels and retained for a longer time compared with traditional small molecule drugs. In particular, covalent camptothecin conjugates are of extensive interest due to their robust stability by covalent chemical bonding. In this mini-review, recent progress of nanosized camptothecin conjugates will be discussed with the focus on the difference of delivery materials as well as their potential of combined drug delivery for the therapy of cancer.

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Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System

Cited by 90 publications

References 58 publications

Supramolecular cyclodextrin-based drug nanocarriers

Supramolecular cyclodextrin-based drug nanocarriers

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Nanosized Camptothecin Conjugates for Single and Combined Drug Delivery

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