2024
DOI: 10.1002/biot.202300308
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Tuning CpG motif position in nanostructured DNA for efficient immune stimulation

Mengmeng Tan,
Natsuki Makiguchi,
Kosuke Kusamori
et al.

Abstract: It was previously demonstrated that polypod‐like nanostructured DNA (polypodna) comprising three or more oligodeoxynucleotides (ODNs) were useful for the delivery of ODNs containing cytosine–phosphate–guanine (CpG) motifs, or CpG ODNs, to immune cells. Although the immunostimulatory activity of single‐stranded CpG ODNs is highly dependent on CpG motif sequence and position, little is known about how the position of the motif affects the immunostimulatory activity of CpG motif‐containing nanostructured DNAs. In… Show more

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