Tuning crystal structure in a micro-scale reactive flow

Perazzo, Antonio; Sicignano, Luca; Tomaiuolo, Giovanna; Marotta, Raffaele; Andreozzi, Roberto; Guido, Stefano

doi:10.1016/j.ces.2019.06.060

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…The final image is produced by the consecutive magnifications of the objective lenses (placed near the specimen) and the ocular and can be viewed directly or captured via a digital camera (e.g., digital video microscopy) [ 144 ]. Especially for fouling investigations, high-speed cameras constitute an essential tool to monitor the phenomena happening at very short times, such as foulants deposition and pore clogging [ 145 , 146 ].…”

Section: Dynamic Investigation Techniquesmentioning

confidence: 99%

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

2021

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The almost ubiquitous, though undesired, deposition and accumulation of suspended/dissolved matter on solid surfaces, known as fouling, represents a crucial issue strongly affecting the efficiency and sustainability of micro-scale reactors. Fouling becomes even more detrimental for all the applications that require the use of membrane separation units. As a matter of fact, membrane technology is a key route towards process intensification, having the potential to replace conventional separation procedures, with significant energy savings and reduced environmental impact, in a broad range of applications, from water purification to food and pharmaceutical industries. Despite all the research efforts so far, fouling still represents an unsolved problem. The complex interplay of physical and chemical mechanisms governing its evolution is indeed yet to be fully unraveled and the role played by foulants’ properties or operating conditions is an area of active research where microfluidics can play a fundamental role. The aim of this review is to explore fouling through microfluidic systems, assessing the fundamental interactions involved and how microfluidics enables the comprehension of the mechanisms characterizing the process. The main mathematical models describing the fouling stages will also be reviewed and their limitations discussed. Finally, the principal dynamic investigation techniques in which microfluidics represents a key tool will be discussed, analyzing their employment to study fouling.

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Section: Dynamic Investigation Techniquesmentioning

confidence: 99%

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

2021

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“…In recent years, microfluidic-based crystallization devices and protocols have received widespread attention for the preparation of drug powder. − Generally, the microchannel exhibits dimensions of tens to hundreds of microns . The small diameter of the channel with a high surface-to-volume ratio can facilitate the heat and mass transfer.…”

Section: Introductionmentioning

confidence: 99%

Continuous Antisolvent Crystallization of Dolutegravir Sodium Using Microfluidics

Liu

Luo

Qiu

et al. 2022

Ind. Eng. Chem. Res.

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Continuous antisolvent crystallization of Dolutegravir Sodium was studied using a novel device integrating the microfluidic continuous crystallizer and the agitated crystallizer. This study successfully minimized the risks of channel blockage during continuous crystallization by innovating an approach to isolate crystal nucleation from subsequent crystal growth. We systematically investigated the effects of the antisolvent content, channel width, and stirring speed on the particle size, the crystal size distribution (CSD), and the morphology of the crystals. By optimization of experimental parameters, crystals can be continuously obtained with small particle sizes (D 50 values of 5−10 μm), narrow CSDs (widths of 4−7 μm), and prismatic morphologies by this apparatus and approach. The particle sizes D 50 and CSDs of crystals are reduced by 30% and 60% at least, respectively, compared with values of the commercial sample. Small and uniform crystals are particularly desirable in the pharmaceutical industry, which can significantly improve drug solubility, bioavailability, corresponding pharmacokinetic performance, and the properties of the tablet.

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“…37 The confinement due to the microfluidic conditions slows down the conversion of the unstable amorphous calcium carbonate into the crystalline form as opposed to the well-stirred reaction where the stable crystalline form appears within seconds to minutes of mixing. [38][39][40] Building upon the versatile applicability of microfluidics, we first study experimentally the precipitation of lithium phosphate in a microchannel and study the effect of flow on the growth of the precipitate particles. The results are then corroborated by simple calculations.…”

Section: Introductionmentioning

confidence: 99%