Tuning Hydroxyapatite Particles' Characteristics for Solid Freeform Fabrication of Bone Scaffolds

Miculescu, Florin; Maidaniuc, Andreea; Stan, George; Miculescu, Marian; Voicu, Ştefan Ioan; Cîmpean, Anișoara; Mitran, Valentina; Batalu, Dan

doi:10.1002/9781119242666.ch7

Cited by 4 publications

(6 citation statements)

References 178 publications

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“…The beginning of a new thermal event was observed at approximately 1200°C, which suggests that β-TCP was partially transformed into α-TCP. This result is in agreement with the previously reported results, which pinpoint the beginning of α-TCP at 1125°C [27,28].…”

Section: Tga/dsc Analysis: Thermal Behavior Of Natural Resourcessupporting

confidence: 94%

“…Following this route, contamination risks were reduced by eliminating all reagents involved in processing and by performing thermal treatment at temperatures above 850°C, which are considered microbiologically safe [27,28]. The preparation procedures for all precursor types are described in detail in Refs.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, thermal treatment of bone tissue aims for producing biphasic calcium phosphates with modulated content of HA and β-TCP, since β-TCP transformation into α-TCP was not identified in bovine bone-derived materials at temperatures lower than 1200°C [27,36]. Adaptation of HA (bioactive)/β-TCP (resorbable) ratio relies upon the precursor features such as substitutions in the crystalline structure of biological apatite, the elemental species embedded in the structure and the interactions between them during thermal processing.…”

Section: Thermal Treatmentmentioning

confidence: 99%

“…For animal bones, isolation and processing of the existent calcium phosphate resource begins with chemical or thermal deproteinization; then, the resulted material is thermally treated in a controlled manner: thermal treatment could be performed by combining different temperatures (700-1400°C), heating environments (air, argon, nitrogen, carbon dioxide) and cooling conditions (air or water with ice) [27,28]. Although methods for manufacturing bovine bone-derived medical devices are standardized [29] and their use is regulated [5], the current research strategies aim to align bovine bone processing to the fifth principle of Green Chemistry and to improve the existent methods by eliminating all reagents which could induce a risk, thus upgrading the quality management approaches related to bovine bone-derived products, their manufacturing and large-scale utilization.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Miculescu¹,

Mocanu²,

Maidaniuc³

et al. 2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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This chapter aims to establish the key factors for technological optimization of biogenic calcium phosphate synthesis from marine and land resources. Three natural calcium sources-marble, seashell and bovine bone-were considered as raw materials. The proposed materials are suitable candidates for the synthesis of bone substitutes similar to the inorganic bone component. The synthesis processes were developed based on the investigations of thermal phenomena (TGA-DSC analysis) that can occur during thermal treatments. By this method, we were able to determine the optimum routes and temperatures for the complete dissociation of calcium carbonate as well as risk-free deproteinization of bovine bone. An exhaustive characterization, performed with modern and complementary techniques such as morphology (SEM), composition (EDS, XRF) and structure (FT-IR, XRD), is presented for each precursor. The final chemical composition of ceramic products can be modulated through a careful control of the key parameters involved in the conversion, in order to create long-term performant biphasic apatite biomaterials, with broad medical applicability. Identifying the suitable strategies for this modulation contributes to an appreciable advance in orthopedic tissue engineering.

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Section: Tga/dsc Analysis: Thermal Behavior Of Natural Resourcessupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Thermal Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Miculescu¹,

Mocanu²,

Maidaniuc³

et al. 2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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“…The diameter of both full structure filaments (not tubular) specified by the manufacturer is of 1.75 ± 0.05 mm.The filaments were placed on a bed of bovine-bone-derived HA powder (synthesized through an established and completely reproductible method, as previously reported [44]), with a particle size of >125 µm, on top of which a new powder layer was added (necessary to completely cover the filament). HA powder was obtained after three thermal processes, one of boiling, one of deproteinization and one of calcination in electric oven, followed by grinding in ball mill and granulometric sorting [20,45,46].The soaked filaments were pressed under the action of different pressing forces (see Figure 1 and Table 1). The next step involved the thermal treatment of these samples into an electrical oven for different periods of time (30', 60', and 120') and different temperatures (195, 205, and 215 • C).…”

mentioning

confidence: 99%

Novel Synthesis of Core-Shell Biomaterials from Polymeric Filaments with a Bioceramic Coating for Biomedical Applications

et al. 2020

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Bone tissue engineering is constantly in need of new material development with improved biocompatibility or mechanical features closer to those of natural bone. Other important factors are the sustainability, cost, and origin of the natural precursors involved in the technological process. This study focused on two widely used polymers in tissue engineering, namely polylactic acid (PLA) and thermoplastic polyurethane (TPU), as well as bovine-bone-derived hydroxyapatite (HA) for the manufacturing of core-shell structures. In order to embed the ceramic particles on the polymeric filaments surface, the materials were introduced in an electrical oven at various temperatures and exposure times and under various pressing forces. The obtained core-shell structures were characterized in terms of morphology and composition, and a pull-out test was used to demonstrate the particles adhesion on the polymeric filaments structure. Thermal properties (modulated temperature and exposure time) and the pressing force's influence upon HA particles' insertion degree were evaluated. More to the point, the form variation factor and the mass variation led to the optimal technological parameters for the synthesis of core-shell materials for prospect additive manufacturing and regenerative medicine applications.Coatings 2020, 10, 283 2 of 18 importance. Among these, PLA was widely used, mainly due to its biocompatibility with the human organism and the advantageous synthesis alternative from sustainable natural resources (e.g., beet or maize) [14]. Along with PLA, TPU was remarked in the additive manufacturing technology [15]. The TPU applications in the medical field spread from blood vessels, implants, and prosthetics, to scaffolding in tissue engineering, dialysis membranes, or breast implants [16].Furthermore, naturally derived hydroxyapatite (HA) is a bioactive ceramic, with similar chemical and structural properties to the mineral component of the natural bone tissue, and exceptional biocompatibility and osteoconductivity. HA can be synthesized from various renewable resources (e.g. fish, sheep, cattle or bovine bones [17,18] or marine shells [19,20]).Along with the development of new biomaterials, the cost-efficient and highly performant processing techniques for final products manufacturing are also in need of improvement. Additive manufacturing (AM) or 3D printing can be considered 21st century technology due to the possibility to attain patient-customized and adapted products [14]. However, the most widely and accessible used technique in orthopedics is fused deposition modeling (FDM) or fused filler fabrication (FFF) [8,14,21,22], which provide 3D scaffolds with a well-defined design by extruding a digital 3D model from thermoplastic polymeric materials heated to their melting point [22].This study aims to provide a new core-shell material that can be used in the FDM technique, targeted due to its rigorous control of parameters (temperature, bed temperature, feed rate, printing speed, etc.) [23][24][25][26][27].Therefore, thi...

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Bioceramic-Starch Paste Design for Additive Manufacturing and Alternative Fabrication Methods Applied for Developing Biomedical Scaffolds

Maidaniuc

Miculescu

2021

3D Printable Gel-Inks for Tissue Engineering

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Tuning Hydroxyapatite Particles' Characteristics for Solid Freeform Fabrication of Bone Scaffolds

Cited by 4 publications

References 178 publications

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Novel Synthesis of Core-Shell Biomaterials from Polymeric Filaments with a Bioceramic Coating for Biomedical Applications

Bioceramic-Starch Paste Design for Additive Manufacturing and Alternative Fabrication Methods Applied for Developing Biomedical Scaffolds

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