The design of new drugs, molecules, nano-, and microstructures for targeted applications is of high impact in Life Sciences. In this context, and mainly for the Corona Virus Pandemic, a fast response is highly required. Thus, the developments of novel approaches are urgently need, seeking improved and highly sensitive solutions in the field of bio detection, in addition to new treatments of SARS CoV-2. In this manner, this short communication discusses the following topics: i) the importance of non-covalent interactions from antibody-antigen recognition events; ii) the genomic factor from virus towards interactions and infections; iii) the importance of the non-covalent interactions on optical detection systems, and iv) the development of new approaches of detection and new treatments based on Smart Responsive Multifunctional Nano-, Microparticles and lab-on particles too. Moreover, it was analyzed the current state of the COVID-19 pandemic, the importance of new treatments in progress and the development of new vaccines and alternative treatments. As well, it is discussed the improvement of highly sensitive and innovative multifunctional Nanophotonic approaches for SARS CoV-2 detection and potential targeted treatments based on non-classical light delivery.