Tuning the Polymer Release from Hydrophilic Matrix Tablets by Mixing Short and Long Matrix Polymers

Körner, Anna; Larsson, Anette; Piculell, Lennart; Wittgren, Bengt

doi:10.1002/jps.20288

Cited by 25 publications

(30 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The profiles for the PEO (0.1:2.0) mixtures, but not those for the PEO (0.006:2.0) mixtures or for PEO 0.3 and PEO 0.9, have been published previously. 13 All tablets gave rise to smooth release profiles, and assuming no systematic measuring errors and normally distributed random errors with constant variance, the standard deviation was estimated to be 1.4%. The overall shape of the release profile was similar for all tablets, with a slower initial release, a linear release during the main release period (10-70%), and a slower release at the end of the experiment.…”

Section: Resultsmentioning

confidence: 99%

“…Differential scanning calorimetric measurements showed only one melting transition for the freeze-dried material, confirming that the two fractions were mixed on the molecular level. 13 The tablets were made in a single-punch tableting machine (Kilian SP300, Kilian & Co, GmbH) equipped with 12.0 mm flat-faced punches. The distance between punches was set to 2.0 mm.…”

Section: Methodsmentioning

confidence: 99%

“…The tablets were made according to a method described in detail earlier. 13 To obtain a homogeneous mixing of the two polymers on the molecular level, a 1% w/w aqueous solution was made of the polymer. The PEO solutions were freeze-dried using a HETO CD 13-2 freeze-drier.…”

Section: Methodsmentioning

confidence: 99%

“…The dissolution experiments were carried out and analyzed according to a method described in detail earlier. 13 The polymer release was studied in a USP dissolution apparatus (Dissolutest, Prolabo) equipped with rotating disks (diameter 50 mm, height 5 mm). A tablet was mounted at the center of a disk using water-impermeable glue, and the disk was rotated at 100 rpm in the dissolution medium (deionized water, 25°C).…”

Section: Methodsmentioning

confidence: 99%

“…The method has been described in a recent study of ours on the same type of bimodal tablets, 13 where only the overall release was studied. In that study it was found that a variation of the degree of crystallinity of the PEO samples, by 20% at most, did not have a significant effect on the dissolution rate of the PEO tablets.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Molecular Information on the Dissolution of Polydisperse Polymers: Mixtures of Long and Short Poly(ethylene oxide)

et al. 2005

Self Cite

View full text Add to dashboard Cite

A systematic study of the dissolution of dry, polydisperse poly(ethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low- and high-molecular-weight fractions was monitored. The high-molecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molecular Information on the Dissolution of Polydisperse Polymers: Mixtures of Long and Short Poly(ethylene oxide)

et al. 2005

Self Cite

View full text Add to dashboard Cite

show abstract

Oral Extended‐Release Formulations

Larsson

Abrahmsén-Alami

Juppo

2010

Pharmaceutical Sciences Encyclopedia

View full text Add to dashboard Cite

In order to achieve therapeutic effect, a drug needs to reach the right place in the body at the right time. For some drugs, this may be achieved by simple solutions or solid dosage forms with an instant drug release while, for others, one has to modify the drug release, such as modified‐release (MR) formulations and oral extended‐release (ER) formulations. This article focuses on formulation principles and manufacturing of the different forms of ER formulations, such as insoluble matrix tablets, membrane‐coated oral extended release, and hydrophilic matrix tablets.

show abstract

Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities

Körner

Larsson

Andersson

et al. 2010

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

Tuning the Polymer Release from Hydrophilic Matrix Tablets by Mixing Short and Long Matrix Polymers

Cited by 25 publications

References 19 publications

Molecular Information on the Dissolution of Polydisperse Polymers: Mixtures of Long and Short Poly(ethylene oxide)

Molecular Information on the Dissolution of Polydisperse Polymers: Mixtures of Long and Short Poly(ethylene oxide)

Oral Extended‐Release Formulations

Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities

Contact Info

Product

Resources

About