Tunneling Nanotubes Between Bone Marrow Stromal Cells Support Transmitophagy and Resistance to Apoptosis in Myeloma

Abstract

Here we show that under oxygen-glucose deprivation (OGD), multiple myeloma cells transfer dysfunctional mitochondria to bone marrow stromal cells (BMSCs) for degradation (transmitophagy). These mitochondria are then transferred between BMSCs via tunneling nanotubes contributing to myeloma survival in OGD.