Tupistra nutans Wall. root extract, rich in phenolics, inhibits microbial growth and α-glucosidase activity, while demonstrating strong antioxidant potential

Chung, Ill‐Min; Chelliah, Ramachandran; Oh, Deog‐Hwan; Kim, Seung Hyun; Yu, Chang Yeon; Ghimire, Bimal Kumar

doi:10.1007/s40415-019-00547-w

Cited by 16 publications

(28 citation statements)

References 57 publications

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“…Taking into account the results of anti‐diabetic and anti‐tyrosinase assays, the findings may be related to phenolic in the leaf extracts. In studies conducted by several authors, a positive correlation was reported between the level of phenolics and the inhibition of these enzymes (Benabderrahim, Elfalleh, Sarikurkcu, & Sarikurkcu, 2019; Chung et al., 2019). In addition, some compounds such as chlorogenic acid, sinapic acid, and isorhamnetin were reported as inhibitory agents (Li, Habasi, Xie, & Aisa, 2014; Zheng et al., 2020).…”

Section: Resultsmentioning

confidence: 96%

Viscum album L. homogenizer‐assisted and ultrasound‐assisted extracts as potential sources of bioactive compounds

et al. 2020

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Viscum album L. (Mistletoe) is one of the most famous plants in many countries utilized for several purposes. The current study aimed to describe chemical profiles and biological activities of homogenizer‐assisted extract (HAE) and ultrasound‐assisted extract (UAE)) of V. album parts (leaf, fruits, and seeds). Antioxidant (radical scavenging, reducing power, metal chelation, and phosphomolybdenum assays) and enzyme inhibitory properties (cholinesterases, amylase, glucosidase, and tyrosinase) were selected for biological evaluation. Chemical profiles were studied by HPLC‐MS/MS and 32 compounds were identified in the extracts; caffeoylquinic acids and its derivatives, dimethylated flavonoids were the most significant compounds. Generally, the leaf extracts exhibited the best antioxidant and enzyme inhibitory effects in our tests. Multivariate analysis was performed to obtain more information for these data, then strong correlations between total bioactive compounds and tested parameters were observed. The present findings encourage us to further investigate V. album as a potential candidate for pharmaceutical and nutraceutical applications. Practical applications Viscum album L. commonly called European mistletoe is a woody perennial shrub growing on coniferous trees with lathery leaves, small flowers, and white berries. It belongs to the Santalaceae R. Br. family from Europe and western/southern Asia. Traditional medicine recognizes mistletoe as a folk remedy to manage inflammation, hypertension, ulcers, and other diseases due to the presence of different bioactive compounds, among them mistletoe lectins and viscotoxins. Recent studies documented the possible therapeutic applications of Viscum extracts in association with cancer's therapy leading to improvements in health and patient's quality of life. Thus, this work gives novel data regarding the phytochemical characterizations and antioxidant/enzymatic inhibitor activities of different types of extracts from seeds, leaves, and fruits of Viscum L. obtained by homogenizer‐assisted and ultrasound‐assisted techniques, in order to increase the data set of potential applications in medicine.

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Section: Resultsmentioning

confidence: 96%

Viscum album L. homogenizer‐assisted and ultrasound‐assisted extracts as potential sources of bioactive compounds

et al. 2020

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“…The concentration and composition of phenolic compounds were identified in M. sacchariflorus using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) system, as described previously [ 111 ]. Pumps (Agilent 1200, Agilent Technologies, Palo Alto, CA, USA) and an autosampler (Agilent 1100 series, Agilent Technologies, Palo Alto, CA, USA) were coupled to an API 2000 series mass spectrometer (Applied Biosystems, ON, Canada) integrated to the LC system.…”

Section: Methodsmentioning

confidence: 99%

Screening of Allelochemicals in Miscanthus sacchariflorus Extracts and Assessment of Their Effects on Germination and Seedling Growth of Common Weeds

Ghimire

Hwang

Sacks

et al. 2020

Plants

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There is increasing interest in the application of bioherbicides because they are less destructive to the global ecosystem than synthetic herbicides. Research has focused on reducing the dependence upon synthetic herbicides by substituting them with environmentally and economically sustainable bioproducts. Allelopathic phytochemicals may be an efficient method for controlling weeds, benefitting both the environment and human health. This study addressed the allelopathic potential of Miscanthus sacchariflorus (MS) extracts on the germination, plant growth, biomass, and biochemical parameters (electrolyte leakage, photosynthetic pigments, and antioxidant enzyme activities) of weeds using laboratory and field experiments. Liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) showed the presence of 22 phenolic compounds, including Orientin, Luteolin, Veratric acid, Chlorogenic acid, Protocatechuic acid, p-Coumaric acid, and Ferulic acid. Leaf extracts of M. sacchariflorus either completely suppressed or partially reduced seed germination and affected the development of weed seedlings (root and shoot length), in a dose-dependent manner. Aqueous extracts of M. sacchariflorus reduced the fresh weight and dry weight, affected the photosynthetic pigment content (chlorophylls, carotenoids), influenced the electrolyte ion leakage, and stimulated the activity of antioxidant enzymes in a species-specific manner. Pearson’s correlation analysis showed that the phenolic compound composition of M. sacchariflorus correlated with the variables tested, indicating that the phytochemicals present in the plant extracts of M. sacchariflorus are a potential source of bio-herbicides.

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“…The phenolic compound concentration and composition were identified in L. chinense using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) system, as described previously by Chung et al [ 68 ]. Pumps (Agilent 1200, Agilent Technologies, Palo Alto, CA, USA) and an autosampler (Agilent 1100 series, Agilent Technologies, Palo Alto, CA, USA) coupled to an API 2000 series, mass spectrometer (Applied Biosystems, Ontario, Canada) were integrated to the LC system.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of Lycium chinense Miller

Thiruvengadam

Ghimire

Kim

et al. 2020

Plants

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This study aimed at investigating the Lycium chinense Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondary metabolites. We also measured the leaf extract antioxidant potential and found that it varies in a concentration-dependent manner. We observed a significant and higher positive correlation between DPPH and ABTS assays compared with the total phenolic and flavonoid content. Furthermore, our assay results positively correlated with several observed acids, indicating their strong association with the L. chinense antioxidant potential. Our cytotoxic assay revealed weak toxicity at higher tested concentrations. Our MIC assay showed that the 80% methanol extract effectively inhibited the growth of Escherichia coli Castellani and Chalmers (ATCC35150). The 625-ppm leaf extract completely suppressed the growth of Staphylococcus aureus Rosenbach (ATCC13150), Bacillus cereus (ATCC 14579), and Helicobacter pylori (ATCC43504). These results allow us to understand the indigenous medicinal value of L. chinense. Our study suggests that the L. chinense leaf extract phenolic compounds possess a good antioxidant activity against free radicals and are effective antimicrobial agents. Finally, the presence and high level of diverse minerals suggest the potential of L. chinense for nutraceutical and functional food applications.

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Tupistra nutans Wall. root extract, rich in phenolics, inhibits microbial growth and α-glucosidase activity, while demonstrating strong antioxidant potential

Cited by 16 publications

References 57 publications

Viscum album L. homogenizer‐assisted and ultrasound‐assisted extracts as potential sources of bioactive compounds

Viscum album L. homogenizer‐assisted and ultrasound‐assisted extracts as potential sources of bioactive compounds

Screening of Allelochemicals in Miscanthus sacchariflorus Extracts and Assessment of Their Effects on Germination and Seedling Growth of Common Weeds

Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of Lycium chinense Miller

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