Turcot syndrome: a case with spinal cord and colonic neoplasms

Radin,; Fortgang, KC; Zee, C.E. van der; Mikity, VG; Halls, James M.

doi:10.2214/ajr.142.3.475

Cited by 26 publications

(12 citation statements)

References 2 publications

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“…İlk semptom ortaya çıktıktan sonra beş yıl içinde diğer semptomlar kendini gösterir (7). Genellikle barsak lezyonları beyin tümörü tanısından bir yıl sonra başgösterir yada postmortem saptanır (6). Ayrıca kolon rezeksiyonundan 2-8 yıl sonra da SSS malignitesi ortaya çıkabilir (6,15).…”

Section: Discussionunclassified

“…Genellikle barsak lezyonları beyin tümörü tanısından bir yıl sonra başgösterir yada postmortem saptanır (6). Ayrıca kolon rezeksiyonundan 2-8 yıl sonra da SSS malignitesi ortaya çıkabilir (6,15). Bizim olgumuzda da kolon kanseri tanısı aldıktan üç yıl sonra serebral semptomlar ortaya çıkmıştır.…”

Section: Discussionunclassified

“…Bizim olgumuzda da kolon kanseri tanısı aldıktan üç yıl sonra serebral semptomlar ortaya çıkmıştır. Cinsiyet ve ırk eğilimi bilinmemektedir fakat 10-30 yaşları arasında görülür (6). Kliniğe yansıması spesifik değildir.…”

Section: Discussionunclassified

“…Turcot Sendromu multiple adenomatöz kolon polipleri ile santral sinir sisteminin (SSS) primer tümörünün birlikte görüldüğü nadir bir hastalıktır (6). İlk olarak 1949'da Crail tarafından tanımlanmış ve 1959'da J. Turcot ve ark.…”

Section: Introductionunclassified

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Colon Cancer and Glioblastoma Multiforme Co-occurrence at an Early Age: A Case Report

Başal¹,

Demırcı²,

Ekinci³

et al. 2015

Acta Oncol Tur.

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Section: Discussionunclassified

Section: Introductionunclassified

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Colon Cancer and Glioblastoma Multiforme Co-occurrence at an Early Age: A Case Report

Başal¹,

Demırcı²,

Ekinci³

et al. 2015

Acta Oncol Tur.

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“…For the most part, the patients with Turcot's syndrome have a familial polyposis; however, the syndrome has been reported in patients with nonfamilial polyposis [ 3 -5 ] , as in our case. The adenomatous polyps of Turcot' s syndrome are histologically identical to those occurring in familial polyposis, although malignant degeneration tends to occur earlier in Turcot's syndrome [2,3,6].…”

Section: Case Reportmentioning

confidence: 99%

Turcot's syndrome: a new case in the first decade of life

et al. 1995

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Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis

Tops¹,

Vasen²,

Henegouwen³

et al. 1992

Am. J. Med. Genet.

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Turcot syndrome (TS) is a rare genetic disease in which brain tumors occur in association with colonic polyposis. Since Turcot's original description in 1959, there have been disagreements about the mode of inheritance as well as the clinical expression of this condition. Some investigators maintain that TS is a phenotypic variant of the autosomal dominant familial adenomatous polyposis (FAP), while others observe that there are clinical differences between TS and FAP, and that the pattern of inheritance of TS is autosomal recessive. The distribution of persons with colonic lesions in a family with a patient of colonic polyposis and a brain tumor, described in this report, favored the recessive hypothesis. In this family, the involvement of the FAP gene on chromosome 5q21-q22 could be excluded by a linkage study using a panel of FAP-linked DNA markers. This finding, which indicates the occurrence of another polyposis gene elsewhere in the genome, will have consequences for the presymptomatic diagnosis of FAP by linked DNA markers. We conclude that TS is a distinct clinical-genetical entity with the triad of atypical polyposis coli, CNS tumors, and a recessive mode of inheritance.

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Turcot syndrome: a case with spinal cord and colonic neoplasms

Cited by 26 publications

References 2 publications

Colon Cancer and Glioblastoma Multiforme Co-occurrence at an Early Age: A Case Report

Colon Cancer and Glioblastoma Multiforme Co-occurrence at an Early Age: A Case Report

Turcot's syndrome: a new case in the first decade of life

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis

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