Turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis

Orhan, Ilkay Erdogan; Şener, Bilge; Atıcı, Tahir; Brun, Reto; Perozzo, Remo; Taşdemir, Deniz

doi:10.1016/j.phymed.2005.10.010

Cited by 82 publications

(60 citation statements)

References 40 publications

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“…However, seaweeds have not been receiving appropriate attention in the past and the availability of algal pharmaceutical data is still scarce compared to that of terrestrial plants [26]. Previous investigation in order to measure the antileishmanial potential from marine algae is extremely limited, being restricted to some species with the test organisms Leishmania donovani [7,27], L. maxicana [6], L. major [9], and L. amazonensis [8], while studies on the Mediterranean species L. infantum are still missing.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of Phycocolloids against the Mediterranean Protozoan Leishmania infantum: An Inceptive Study

et al. 2016

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Sulfated polysaccharides from marine macroalgae have been shown to possess a variety of biological activities against fungi, bacteria, viruses, and protozoa. In this study, the in vitro activity of algal polysaccharides against Leishmania infantum (Kinetoplastida: Trypanosomatidae) was investigated. The polysaccharides were extracted from different macroalgae of the Mediterranean Sea: Chaetomorpha linum, Agardhiella subulata, Gracilaria viridis, Gracilaria bursa-pastoris, Hypnea cornuta, Sargassum muticum, and Undaria pinnatifida. Preliminary results showed a good anti-leishmanial activity of the investigated species, encouraging the focus on their use as natural resources in order to match integrated management strategies for the employment of local macroalgae.

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Section: Discussionmentioning

confidence: 99%

Bioactivity of Phycocolloids against the Mediterranean Protozoan Leishmania infantum: An Inceptive Study

et al. 2016

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“…Seaweed crude extracts extracts of Ulva reticulata and Ulva rigida have been documented to exhibit strong in vitro activity against the promastigote form of Leshmania major with IC 50 of 64.75µg/ml and 65.69µg/ml respectively [32]. Leishmanicidal potential of different marine and fresh macrophytes have been reported [33] highlighting the antiprotozoal potential of Ulva lactuca extract. In fact, U. lactuca displayed the most potent activity against axenic amastigotes of Leshmania donovani with IC 50 =5.9ml/ml and efficiently inhibited the FabI enzyme.…”

Section: Antiprotozoalmentioning

confidence: 99%

Pharmacological Potential of Ulva Species: A Valuable Resource

Ktari¹

2017

JAPLR

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With the emergence of new diseases, the increase of pathogenic strains resistance and the apprehensiveness of synthetic compounds side effects, there is a constant need to find natural and low toxicity drug candidates. Seaweeds are rich source of original and bioactive natural substances. In particular, species of the genus Ulva have been demonstrated to metabolize biomolecules with pharmacological potential. This mini review present some of the biological properties reported for Ulva spp.

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“…They have extracted antiprotozoal compound by chloroform, the major [40]. The ethanolic extracts of freshwater macrophytes Potamogeton perfoliatus, Ranunculus tricophyllus and Cladophora glomerata as well as marine macroalgae Dictyota dichotoma, Halopteris scoparia, Posidonia oceanica, Scinaia furcellata, Sargassum natans and Ulva lactuca are assayed for their in vitro antiprotozoal activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum [41].…”

Section: Antiprotozoal and Antiplasmodial Activity Of Algaementioning

confidence: 99%