Tuscany Sangiovese grape juice imparts cardioprotection by regulating gene expression of cardioprotective C-type natriuretic peptide

Svezia, B.; Cabiati, Manuela; Matteucci, Marco; Passino, Claudio; Pè, Mario Enrico; Lionetti, Vincenzo; Ry, Silvia Del

doi:10.1007/s00394-019-02134-x

Cited by 14 publications

(7 citation statements)

References 70 publications

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“…JQFJ treatment led to dose-dependent cardioand vasoprotective effects. Antiatherogenic and cardioprotective effects have also been reported for other fruit juices -black chokeberry [8], pomegranate [9], grapes [10], orange [11] and many others. It has long been known that consumption of plant foods correlates with a lower cardiovascular risk [8][9].…”

Section: Discussionmentioning

confidence: 88%

Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats

Moneva-Marinova,

Tzaneva,

Gasanzadeeva

et al. 2023

Journal of Biomedical and Clinical Research

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Summary The current study aimed to evaluate the influence of Japanese quince (Chaenomeles japonica) fruit juice (JQFJ) on the myocardium and on the coronary arteries of rats with diet-induced metabolic syndrome (MS). Male Wistar rats (n=50) were divided into 5 groups: Control, MS, MS+JQFJ2.5, MS+JQFJ5 and MS+JQFJ10. MS was induced with a high-fat high-fructose diet for 10 weeks. During that period, all animals were daily orally treated with distilled water (Control and MS groups) or with JQFJ at doses of 2.5 ml/kg, 5 ml/kg and 10 ml/kg (the other three groups, respectively). At the end of the experiment, the myocardium and coronary arteries were examined histopathologically. In group MS, necrotic endothelial cells and exposed basal membrane were observed. JQFJ at 2.5 ml/kg reduced the impairment but activated endothelial cells were still found. JQFJ at 5 ml/kg and 10 ml/kg prevented coronary artery endothelium damage, preserving the normal morphology. The myocardium in MS group presented with cardiomyocyte degeneration and increased distance between the cells. In group MS+JQFJ2.5, the degeneration was decreased. In groups MS+JQFJ5 and MS+JQFJ10, the histology of the myocardium resembled that of the control group. In the current histopathological evaluation, JQFJ prevented the MS-induced impairment of myocardium and coronary arteries.

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Section: Discussionmentioning

confidence: 88%

Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats

Moneva-Marinova,

Tzaneva,

Gasanzadeeva

et al. 2023

Journal of Biomedical and Clinical Research

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“…105 Interestingly, recent evidence suggests that grapefruit-derived polyphenols could modify miRNA expression in a sex-dependent manner. 106 In the setting of pathological conditions such as myocardial infarction, high levels of circulating miR-574-5p are found to associate with a poor neurological outcome after cardiac arrest in women but not in men. 107 estradiol levels are elevated in both male and female patients after cardiac arrest 108 and miR-574-5p expression has been shown to be upregulated by estradiol treatment in breast cancer cells.…”

Section: Sex-biased Mirna Expression In Cardiovascular Health and Dis...mentioning

confidence: 99%

“…However, micronutrients like vitamins and polyphenols may have a role in epigenetic regulation of cardiovascular function too 105 . Interestingly, recent evidence suggests that grapefruit‐derived polyphenols could modify miRNA expression in a sex‐dependent manner 106 …”

Section: Epigenetic Regulation and Sex Differences In Cardiovascular ...mentioning

confidence: 99%

MicroRNA in cardiometabolic health and disease: The perspectives of sex, gender and personalised medicine

Ministrini,

Padro

2024

Eur J Clin Investigation

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BackgroundPersonalized medicine represents a novel and integrative approach that focuses on an individual's genetics and epigenetics, precision medicine, lifestyle and exposures as key players of health status and disease phenotypes.MethodsIn this narrative review, we aim to carefully discuss the current knowledge on gender disparities in cardiometabolic diseases, and we consider the sex‐ specific expression of miRNAs and their role as promising tool in precision medicine.ResultsPersonalised medicine overcomes the restricted care of patient based on a binomial sex approach, by enriching itself with a holistic and dynamic gender integration. Recognized as a major worldwide health emergency, cardiometabolic disorders continue to rise, impacting on health systems and requiring more effective and targeted strategies. Several sex and gender drivers might affect the onset and progression of cardiometabolic disorders in males and females at multiple levels. In this respect, distinct contribution of genetic and epigenetic mechanisms, molecular and physiological pathways, sex hormones, visceral fat and subcutaneous fat and lifestyle lead to differences in disease burden and outcomes in males and females.ConclusionsSex and gender play a pivotal role in precision medicine because the influence the physiology of each individual and the way they interact with environment from intrauterine life.

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“…Myocardial infarction is a severe and common type of cardiovascular disease caused by acute occlusion of coronary arteries. The results of a study by Svezia et al suggest that pure grape juice protected the myocardium from an ischemic microenvironment and protected infarcted hearts by regulating gene expression of C-type natriuretic peptide, which is among the major autocrine/paracrine regulators of cardiac remodeling in infarcted hearts, acting as an endothelium-derived hyperpolarizing factor, modulating vascular tension and blood flow [ 7 ]. In addition, grape seed proanthocyanidin extract effectively improved cardiac remodeling and dysfunction caused by myocardial infarction in mice and protected cardiomyocytes from apoptosis in hypoxic situations through the PI3K/Akt pathway [ 63 ].…”

Section: Health Benefits Of Grapementioning

confidence: 99%

“…The annual production of grape is approximately 75 million tons, with the largest production in Europe (about 41%), followed by Asia (29%) and the Americas (21%) [ 2 , 3 ]. Many studies have reported that grape exhibits a variety of biological activities, such as antioxidant [ 4 , 5 ], gut-microbiota-regulating [ 6 ], cardioprotective [ 7 , 8 ], antidiabetic [ 9 ] and anticancer activities [ 10 , 11 ]. For example, a double-blind, placebo-controlled randomized clinical trial (RCT) revealed that the consumption of 46 g lyophilized grape powder (equivalent to 252 g fresh grape) resulted in antioxidant and anti-inflammatory activities in men with metabolic syndrome in the absence of dyslipidemia [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds, Health Benefits and Food Applications of Grape

Zhou

Xiong

et al. 2022

Foods

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Grape (Vitis vinifera L.) is one of the most popular fruits worldwide. It contains various bioactive compounds, such as proanthocyanidins, anthocyanins, flavonols, phenolic acids and stilbenes, the contents of which could vary considerably in grape skin, pulp and seed. Many studies have revealed that grape possesses a variety of health benefits, such as antioxidant, anti-inflammatory, gut-microbiota-modulating, anticancer and cardioprotective effects. Grape is eaten as fresh fruit and is also used as raw material to produce various products, such as wine, grape juice and raisins. Moreover, the byproducts of grape, such as grape pomace and grape seed, have many applications in the food industry. In this paper, the bioactive compounds in grape are briefly summarized based on literature published in recent years. In addition, the health benefits of grape and its bioactive components are discussed, with special attention paid to the underlying mechanisms. Furthermore, the applications of grape in the food industry are elucidated, especially the applications of grape pomace and grape seed. This paper can contribute to understanding the health benefits and mechanisms of grape and its bioactive compounds, as well as the promotion of the use of grape in the food industry.

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Tuscany Sangiovese grape juice imparts cardioprotection by regulating gene expression of cardioprotective C-type natriuretic peptide

Cited by 14 publications

References 70 publications

Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats

Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats

MicroRNA in cardiometabolic health and disease: The perspectives of sex, gender and personalised medicine

Bioactive Compounds, Health Benefits and Food Applications of Grape

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