2023
DOI: 10.3390/ph17010019
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Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery

Alaa Eldeen B. Yassin,
Salam Massadeh,
Abdullah A. Alshwaimi
et al.

Abstract: Valsartan (Val) is an important antihypertensive medication with poor absorption and low oral bioavailability. These constraints are due to its poor solubility and dissolution rate. The purpose of this study was to optimize a mixed micelle system for the transdermal delivery of Val in order to improve its therapeutic performance by providing prolonged uniform drug levels while minimizing drug side effects. Thin-film hydration and micro-phase separation were used to produce Val-loaded mixed micelle systems. A v… Show more

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