Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial

Mądry, Edyta; Chudzicka-Strugała, Izabela; Grabańska-Martyńska, Katarzyna; Malikowska, Klaudia; Grebowiec, Philip; Lisowska, Aleksandra; Bogdański, Paweł; Walkowiak, Jarosław

doi:10.17306/j.afs.2016.1.11

Cited by 18 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were eight studies that did not report between‐group data over time. Of the five high‐quality studies (e.g., low risk of bias) (105‐109), only one demonstrated a statistically significant weight loss in their two intervention (vs. placebo) groups ranging from 1.5 to 3.0 kg (105) (Supporting Information Tables S12A‐D).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss

Batsis

Apolzan

Bagley

et al. 2021

Obesity

View full text Add to dashboard Cite

ObjectiveDietary supplements and alternative therapies are commercialized as a panacea for obesity/weight gain as a result of the minimal regulatory requirements in demonstrating efficacy. These products may indirectly undermine the value of guideline‐driven obesity treatments. Included in this study is a systematic review of the literature of purported dietary supplements and alternative therapies for weight loss.MethodsA systematic review was conducted to evaluate the efficacy of dietary supplements and alternative therapies for weight loss in participants aged ≥18 years. Searches of Medline (PubMed), Cochrane Library, Web of Science, CINAHL, and Embase (Ovid) were conducted. Risk of bias and results were summarized qualitatively.ResultsOf the 20,504 citations retrieved in the database search, 1,743 full‐text articles were reviewed, 315 of which were randomized controlled trials evaluating the efficacy of 14 purported dietary supplements, therapies, or a combination thereof. Risk of bias and sufficiency of data varied widely. Few studies (n = 52 [16.5%]) were classified as low risk and sufficient to support efficacy. Of these, only 16 (31%) noted significant pre/post intergroup differences in weight (range: 0.3‐4.93 kg).ConclusionsDietary supplements and alternative therapies for weight loss have a limited high‐quality evidence base of efficacy. Practitioners and patients should be aware of the scientific evidence of claims before recommending use.

show abstract

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss

Batsis

Apolzan

Bagley

et al. 2021

Obesity

View full text Add to dashboard Cite

show abstract

“…Because of the common coexistence of HT and obesity the selection of a large group of obese subjects without HT was impossible. A limitation of the study is the small number of participants, according to a restriction of the sample size calculation described in our previous article (11). …”

Section: Discussionmentioning

confidence: 99%

“…The CLA capsules contained 0.5 g of 80% CLA (50:50 cis -9, trans -11 and trans -10, cis -12 isomers), and placebo capsules contained 0.5 g of sunflower oil. The fatty acid compositions of both capsules were presented in our previous article (11). …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women

Duś-Żuchowska

Mądry

Krzyżanowska

et al. 2016

Food & Nutrition Research

View full text Add to dashboard Cite

BackgroundThe antiatherogenic effect of conjugated linoleic acid (CLA) has been demonstrated in animal models. Although there are plenty of in vitro studies that suggest the profitable properties of CLA, the results in humans remain inconsistent.ObjectiveIn this study, we assessed the impact of CLA supplementation on the levels of atherosclerosis markers – high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA).DesignSeventy-four adult female subjects with body mass index ≥25 kg/m2 were enrolled in the double-blind, placebo-controlled nutritional intervention. The study participants were randomly assigned to receive 3 g/day CLA or placebo (sunflower oil) for 12 weeks. In all subjects, we measured hs-CRP and ADMA concentrations by using enzyme-linked immunosorbent assay.ResultsNo significant differences were found in hs-CRP and ADMA levels before and after nutritional intervention between both groups. The changes in hs-CRP and ADMA concentration values (Δhs-CRP; ΔADMA median [interquartile range]) did not differ between subjects from the placebo (−0.1 [−0.8 to 0.3]; −0.02 [−0.12 to 0.14]) and CLA (0.2 [−0.7 to 0.9]; 0.04 [−0.14 to 0.13]) groups. The incidence of reduction of hs-CRP or ADMA concentration was not different in subjects of the CLA group compared to those of the placebo group (41.9% vs. 50%, relative risk [RR]=0.8387, 95% confidence interval [CI]=0.4887–1.4493, p=0.5232 and 61.3% vs. 56.2%, RR=1.0896, 95% CI=0.7200–1.6589, p=0.6847, respectively).ConclusionTwelve weeks of CLA supplementation had no effect on selected markers of atherosclerosis in obese and overweight women.

show abstract

“…Although humans can produce endogenous CLA, the blood and tissue levels of CLA in non-supplemented individuals are less (21,22) . According to prior investigations, isomer 10, 12 CLA seems to elicit the greatest beneficial effect on promoting weight loss in animals and humans (23)(24)(25) . One proposed explanation behind CLA action may be stimulating apoptotic mechanisms and regulating lipolytic pathways, both of which positively affect body composition and weight loss in humans (26) .…”

mentioning

confidence: 95%

The effects of conjugated linoleic acid supplementation on anthropometrics and body composition indices in adults: a systematic review and dose–response meta-analysis

Asbaghi,

Shimi,

Hosseini Oskouie

et al. 2023

Br J Nutr

View full text Add to dashboard Cite

Prior meta-analytic investigations over a decade ago rather inconclusively indicated that conjugated linoleic acid (CLA) supplementation could improve anthropometric and body composition indices in the general adult population. More recent investigations have emerged, and an up-to-date systematic review and meta-analysis on this topic must be improved. Therefore, this investigation provides a comprehensive systematic review and meta-analysis of randomized controlled trials (RCTs) on the impact of CLA supplementation on anthropometric and body composition (body mass [BM], boy mass index [BMI], waist circumference [WC], fat mass [FM], body fat percentage [BFP], and fat-free mass [FFM]) markers in adults. Online databases search, including PubMed, Scopus, the Cochrane Library, and Web of Science up to March 2022, were utilized to retrieve RCTs examining the effect of CLA supplementation on anthropometric and body composition markers in adults. Meta-analysis was carried out using a random-effects model. The I2 index was used as an index of statistical heterogeneity of RCTs. Among the initial 8351 studies identified from electronic databases search, 70 RCTs with 96 effect sizes involving 4159 participants were included for data analyses. The results of random-effects modeling demonstrated that CLA supplementation significantly reduced BM (WMD: -0.35, 95% CI: -0.54, -0.15, p<0.001), BMI (WMD: -0.15, 95% CI: -0.24, -0.06, p=0.001), WC (WMD: -0.62, 95% CI: -1.04, -0.20, p=0.004), FM (WMD: -0.44, 95% CI: -0.66, -0.23, p<0.001), BFP (WMD: -0.77 %, 95% CI: -1.09, -0.45, p<0.001), and increased FFM (WMD: 0.27, 95% CI: 0.09, 0.45, p=0.003). The high-quality subgroup showed that CLA supplementation fails to change FM and BFP. However, according to high-quality studies, CLA intake resulted in small but significant increases in FFM and decreases in BM and BMI. This meta-analysis study suggests that CLA supplementation may result in a small but significant improvement in anthropometric and body composition markers in an adult population. However, data from high-quality studies failed to show CLA’s body fat-lowering properties. Moreover, it should be noted that the weight loss properties of CLA were small and may not reach clinical importance.

show abstract

Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial

Cited by 18 publications

References 18 publications

A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss

A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss

Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women

The effects of conjugated linoleic acid supplementation on anthropometrics and body composition indices in adults: a systematic review and dose–response meta-analysis

Contact Info

Product

Resources

About