Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese schoolchildren

Abstract

Objective: To examine the association between 24 h urinary water-soluble vitamin levels and their intakes in free-living Japanese schoolchildren. Design: All foods consumed for four consecutive days were recorded accurately by a weighed food record. A single 24 h urine sample was collected on the fourth day, and the urinary levels of water-soluble vitamins were measured. Setting: An elementary school in Inazawa City, Japan. Subjects: A total of 114 healthy, free-living, Japanese elementary-school children aged 10-12 years. Results: The urinary level of each water-soluble vitamin was correlated positively to its mean intake in the past 2-4 d (vitamin B 1 : r 5 0?42, P , 0?001; vitamin B 2 : r 5 0?43, P , 0?001; vitamin B 6 : r 5 0?49, P , 0?001; niacin: r 5 0?32, P , 0?001; niacin equivalents: r 5 0?32, P , 0?001; pantothenic acid: r 5 0?32, P , 0?001; folic acid: r 5 0?27, P , 0?01; vitamin C: r 5 0?39, P , 0.001), except for vitamin B 12 (r 5 0?10, P 5 NS). Estimated mean intakes of water-soluble vitamins calculated using urinary levels and recovery rates were 97-102 % of their 3 d mean intake, except for vitamin B 12 (79 %). Conclusions:The results show that urinary levels of water-soluble vitamins, except for vitamin B 12 , reflected their recent intakes in free-living Japanese schoolchildren and could be used as a potential biomarker to estimate mean vitamin intake.

Relationship between Urinary Concentrations of Nine Water-soluble Vitamins and their Vitamin Intakes in Japanese Adult Males

“…We previously determined that measuring the biomarkers of water-soluble vitamins in urine samples were better than in blood samples. We also investigated the relationship between urinary excretion and intakes of water-soluble vitamins in humans and animals 1–27. We confirmed that water-soluble vitamins were available as nutritional biomarkers for assessing their intake in females.…”

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

“…The 24-hour urinary excretion of cobalamin is not correlated with recent dietary intake (Fukuwatari et al, 2009;Tsuji et al, 2010Tsuji et al, , 2011. Proximal tubule receptor-mediated reabsorption of filtered holoTC, mediated by megalin, efficiently prevents urinary losses of the vitamin and is a saturable process (Birn, 2006).…”

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

“…Japanese elderly females aged 70-84 years were participated (Tsuji et al, 2010a(Tsuji et al, , 2010b(Tsuji et al, , 2011. The subjects performed 4-day dietary assessment by recording all food consumed during the consecutive 4-day period with a weighed food record, and collected 24-hr urine samples on the fourth day.…”

“…Measured values for 24-hr urinary excretion collected on Day 4 and daily vitamin intake for each water-soluble vitamin, and correlation between 24-hr urinary excretion and daily vitamin intake in Japanese school children (n=114) (Tsuji et al, 2010b Table 3. Measured values for 24-hr urinary excretion collected on Day 4 and daily vitamin intake for each water-soluble vitamin, and correlation between 24-hr urinary excretion and daily vitamin intake in elderly Japanese (n=35) (Tsuji et al, 2011). a Mean dietary intake was calculated using daily dietary intake for each individual.…”

“…Table 6. Correlations between 24-hr urinary excretion and mean vitamin intakes, recovery rates, and mean estimated intakes in elderly Japanese (n=35) (Tsuji et al, 2011).…”