Two allergens from Scylla paramamosain share common epitopes showed different allergenic potential in Balb/c mice

Study on the Sensitization and Antigenic Epitopes of Tropomyosin from Antarctic Krill (Euphausia superba)

“…In our experiment, high levels of sIgE were detected in TM-sensitized mice, and mice were accompanied with different degrees of allergic symptoms, indicating that the increased IFN-γ (Figure F) might be mainly involved in the inflammatory reaction of the body. Consistent with our experimental results, many studies have found elevated levels of IFN-γ in antigen-sensitized mice (vs the NC group). , The Th1 immune response is characterized by the production of cytokines IL-2, TNF-β, and IFN-γ. The Th2 response is characterized by the production of cytokines IL-4, IL-5, and IL-13 and an enhanced production of IgG1. , IFN-γ levels in the medium-dose group showed no significant differences (vs NC, Figure F).…”

“…AK has also been proven to be a common allergen in invertebrates, which has been identified in different species such as shrimp, octopus, and crab . Other allergenic proteins found in crustaceans include sarcoplasmic calcium-binding protein, troponin C, hemocyanin, and triosephosphate isomerase. , …”

“…8 Other allergenic proteins found in crustaceans include sarcoplasmic calcium-binding protein, troponin C, hemocyanin, and triosephosphate isomerase. 9,10 Hoffman et al 11 made the groundbreaking discovery that the brown shrimp allergen is a 36 kDa protein, paving the way for other researchers to investigate the allergens found in crustacean aquatic products. As a major crustacean allergen, TM has been identified and registered by WHO/IUIS (www.…”

Enzyme-Linked Immunosorbent Assay-Based Microarray on a Chip for Bioaerosol Sensing: Toward Sensitive and Multiplexed Profiling of Foodborne Allergens

“…1,2 Food allergy is an immunopathological reaction of the human immune system upon exposure to even trace amounts of foodborne allergens, 3 which may induce acute and hypersensitive symptoms such as gastrointestinal illness, urticaria, or airway inflammation. 4 Given the profound influence of food allergy, timely and accurate determination of allergenic sources is essential to the prevention of allergic diseases and can aid with better medical decision-making and proper alleviation of acute allergic syndromes. 5 Nevertheless, currently available clinical tests, such as chromatographic, spectroscopic, or immunological strategies, are often unavailable in low income nations due to resource limitations.…”

“…Food allergy has posed an increasingly significant threat on human health globally. The prevalence of food allergy is estimated to be 3–8% of the gross population, accounting for up to 6% of children and up to 4% of adults. , Food allergy is an immunopathological reaction of the human immune system upon exposure to even trace amounts of foodborne allergens, which may induce acute and hypersensitive symptoms such as gastrointestinal illness, urticaria, or airway inflammation . Given the profound influence of food allergy, timely and accurate determination of allergenic sources is essential to the prevention of allergic diseases and can aid with better medical decision-making and proper alleviation of acute allergic syndromes .…”