Two Bioactive Pterocarpans from Erythrina burana

Dagne, Ermias; Gunatilaka, A. A. Leslie; Kingston, David G. I.; Alemu, Mekbib; Hofmann, Glenn A.; Johnson, Randall K.

doi:10.1021/np50100a028

Cited by 49 publications

(26 citation statements)

References 5 publications

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“…as established through HMBC correlations. The CD spectrum, which showed a positive Cotton effect at 315 nm and the negative optical rotation (½a 25 D ¼ À14:0) are consistent with the 6aR:11aR absolute configuration (Dagne et al, 1993), establishing 1 (erylysin A), as (6aR,11aR)-3 00 -hydroxy-2 0 ,2 0 -dimethylpyrano[6 0 ,5 0 :3,4]-2 00 ,2 00 -dimethyldihydropyrano[6 00 ,5 00 :9,10]pterocarpan ( Fig. 1).…”

Section: Resultssupporting

confidence: 61%

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

et al. 2009

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Section: Resultssupporting

confidence: 61%

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

et al. 2009

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“…The antimicrobial activity previously observed with the genus Erythrina (Mitscher et al, 1988;Dagne et al, 1993) is confirmed by the remarkable effect of the roots of Erythrina vogelii against Gram-positive cocci as well as C. cucumerinum. Further work is underway in order to identify the active principles of E. vogelii.…”

Section: Discussionmentioning

confidence: 62%

Evaluation of the antimicrobial potential of medicinal plants from the Ivory Coast

Atindehou

Koné

Terreaux

et al. 2002

Phytotherapy Research

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A total of 148 crude ethanol extracts from 115 plant species were tested in vitro against Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) and the Gram-positive Staphylococcus aureus and Enterococcus faecalis. Moreover, they were submitted to antifungal assays against Candida albicans and Cladosporium cucumerinum, a human and a plant pathogenic microorganism, respectively, known to be good indicators of antifungal activity. No activity was detected against the Gram-negative bacteria, while 14.8% and 10.8% of the extracts showed Gram-positive bactericidal or bacteriostatic effects on S. aureus and E. faecalis, respectively. An antifungal activity was observed with 15 extracts (10.1%). Two species were particularly active against the fungi: Dioscorea minutiflora and Erythrina vogelii. The young tubers of D. minutiflora contain metabolites with a specific effect on fungi and were not active against the bacteria. On the other hand, E. vogelii was highly effective against the Gram-positive bacteria and the fungi.

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“…The last one has previously been isolated from other species of the genus Erythrina, but not of E. velutina. On the other hand, it was the first time that homohesperetin has been isolated from a plant of the Fabaceae family (Dagne et al, 1993;Nkengfak et al, 1994;Tanaka et al, 1997). It was also already isolated five major alkaloids from the methanol extract of E. mulungu flowers.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan-and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24 th h. Em (200 or 400 mg/kg) presented antiinflammatory effect at the 2, 3 and 4 th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

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Two Bioactive Pterocarpans from Erythrina burana

Cited by 49 publications

References 5 publications

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

Evaluation of the antimicrobial potential of medicinal plants from the Ivory Coast

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

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