Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Lombardini, Eric; Summers, B. A.

doi:10.1016/j.jcpa.2012.05.011

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…PROX-1 IHC was used to confirm that the tumor arose from malignant lymphatics. In the two previously reported canine cases, only blood vessel endothelial markers (CD31 and vWf) were reported (15). While this tumor's positive labeling for PROX-1 supports classification of the angiosarcoma as a LAS, other subtypes of HE, such as Kaposiform HE and tufted angiosarcoma, have both been shown to express PROX-1 in people (18).…”

Section: Discussionsupporting

confidence: 49%

“…In comparison with the human correlate, these two cases were more aggressive, as disseminated metastatic disease was present. In one case that was diagnosed at necropsy, metastatic lesions were present within the right atrium, spleen, lungs, brain, and cervical spinal cord (15). Here, we describe the first reported case of a pleomorphic LAS with features of CHE described in the dog.…”

Section: Discussionmentioning

confidence: 80%

“…Hemangiosarcoma, however, is a very commonly diagnosed entity in the dog, primarily arising in the spleen, right atrium and auricle, skin and subcutaneous tissues (14). To date, only two cases of canine angiosarcomas with features of human RH have been described (15). Histopathologic features of these cases included the presence of elongated vascular channels, bulging hobnail nuclei, and marked lymphoplasmacytic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…LAS is an uncommon diagnosis in the dog, and while survival data are limited, improved patient outcomes have been reported following multimodal therapy (4). To date, only two cases of canine angiosarcoma with features of RH have been reported in the veterinary literature (15). Both of these cases had advanced disease present at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Cutaneous Pleomorphic Lymphangiosarcoma in a Dog Exhibiting Features of Human Composite Hemangioendothelioma

et al. 2021

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Background: Angiosarcomas are a broad category of vascular origin neoplasms that are poorly characterized in veterinary species. Lymphangiosarcoma (LAS) is an uncommon type of angiosarcoma reported in humans and canines arising from lymphatic endothelium. LAS can be differentiated from other angiosarcomas in dogs based on expression of Prospero-related homeobox gene-1 (PROX-1) or lymphatic vessel endothelial receptor-1 (LYVE-1). Composite hemangioendothelioma (CHE) is a rare angiosarcoma subtype described in people and characterized by a variable biologic behavior and infrequent metastasis. This variant of angiosarcoma histologically combines features of retiform hemangioendothelioma and epithelioid hemangioendothelioma. Information regarding the cytologic and histopathologic appearance and clinical course of dogs with vascular tumors that exhibit features of CHE are unknown. Here, we report a case of pleomorphic LAS with features of CHE arising in a dog and treated with surgery and adjuvant chemotherapy.Case presentation: A 10-year-old intact male Labrador retriever presented with an approximately 6-cm-diameter cutaneous mass caudal to the left elbow that was progressively growing over 1.5 years. On physical examination, palpable extensions were identified coursing proximally over the triceps with concurrent loco-regional peripheral lymphadenopathy. Fine needle aspirates (FNA) and cytologic assessment of the cutaneous mass, left prescapular, and accessory axillary lymph nodes reported that this appeared to be a metastatic epithelial neoplasm, although a mixed carcinoma or collision tumor could not be excluded. An incisional biopsy of the mass was submitted for histopathology and was consistent with a well-differentiated angiosarcoma with features of CHE. The neoplasm expressed vimentin, CD31, von Willebrand factor (vWf), and PROX-1, supporting the diagnosis of LAS. Complete staging was performed, and no additional metastatic lesions were identified. Left forelimb amputation and lymph node removal were performed. Based on the diagnosis of metastatic LAS, doxorubicin chemotherapy was administered. 7 months post-amputation, the tumor recurred at the amputation site without evidence of metastatic disease.Conclusion: This report describes a malignant, locally aggressive lymphatic origin vascular tumor in a dog, with features consistent with descriptions of CHE in humans. Cytologic features in this case were discordant with its true mesenchymal etiology, obfuscating diagnosis. The morphologic features of the mesenchymal neoplastic population and immunohistochemistry (IHC) labeling ultimately supported a diagnosis of pleomorphic LAS with features of CHE.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Case Report: Cutaneous Pleomorphic Lymphangiosarcoma in a Dog Exhibiting Features of Human Composite Hemangioendothelioma

et al. 2021

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“…Till now, less than 35 cases were reported worldwide which include two cases of canine retiform hemangioendothelioma [5–8]. RH tumor is first described in 1994 and it is closely related to Dabska tumor (DT) [2].…”

Section: Introductionmentioning

confidence: 99%

A Rare Presentation of Retiform Hemangioendothelioma in the External Auditory Canal

Jothi

Sundaram

Namasivayam

et al. 2014

Case Reports in Otolaryngology

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Retiform hemangioendothelioma is a rare intermediate or borderline neoplasm of the blood vessels that mostly occurs in extremities. Here we report a unique case of retiform hemangioendothelioma presented in the external auditory canal. 58-year-old male patient presented with the complaint of right ear swelling for 4 years. On examination, a spherical swelling in the right ear was found occluding the view of external auditory canal. The tumor was removed surgically. Intraoperatively, the mass was found attached to the outer part of the right external auditory canal near the root of helix. Histopathology of the resected tumor showed typical features of retiform hemangioendothelioma. In addition, immunohistochemical analysis revealed that tumor was positive for endothelial cell marker CD34 and occasionally positive for cell proliferative marker Ki-67.

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Tumors of the Hemolymphatic System

Valli

Bienzle

Meuten

2016

Tumors in Domestic Animals

110

242

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Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Cited by 5 publications

References 19 publications

Case Report: Cutaneous Pleomorphic Lymphangiosarcoma in a Dog Exhibiting Features of Human Composite Hemangioendothelioma

Case Report: Cutaneous Pleomorphic Lymphangiosarcoma in a Dog Exhibiting Features of Human Composite Hemangioendothelioma

A Rare Presentation of Retiform Hemangioendothelioma in the External Auditory Canal

Tumors of the Hemolymphatic System

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