Two cases of peripheral odontogenic fibroma arising in the maxillary anterior region − A new diagnostic method using immunostaining −

Abstract

We report two cases of peripheral odontogenic fibroma of the maxillary anterior gingiva. The first patient was a 46-year-old woman with a three-year history of a painless mass near the left maxillary lateral incisor tooth. Intraoral examination revealed a firm nodule with a smooth surface. CT images showed a radiolucent lesion consistent with the mass. The second patient was a 41-year-old woman who had been aware of an asymptomatic hemorrhagic mass situated in the maxillary midline gingiva. The clinical examination revealed a coral pinkish nodule attached to the gingiva. CT examination did not show any abnormal findings. Both lesions were surgically resected with a 2mm safety margin under local anesthesia. The histological characteristics of both lesions included proliferation of fibroblasts and the presence of collagenous stromacontaining inactive odontogenic epithelium. Immunohistochemically, both cases were negative for CD34 and positive for Bcl-2. Both patients showed no evidence of recurrence associated with peripheral odontogenic tumors.