Two cases of somatic-type malignancy as a very late relapse of testicular cancer successfully managed by surgical resection

Washino, Satoshi; Konishi, Tsuzumi; Saito, Kimitoshi; Ohshima, Masashi; Nakamura, Yoshikuni; Miyagawa, Tomoaki

doi:10.1093/jscr/rjx233

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…SM arising from a GCT is a rare phenomenon, occurring in approximately 2.7% to 8.6% of GCT cases, and is more commonly observed in late relapse cases [ 8 - 10 ]. SMs have mostly been described with teratomas; however, non-teratomatous associations have been observed as well [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Germ Cell Tumor With Somatic-Type Malignancy: A Case Report and Review of the Literature

Cheema¹,

Siddiqui²,

Kamran³

2022

Cureus

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A malignant germ cell tumor (GCT) might contain or transform into malignant non-germ cell histology, commonly referred to as somatic-type malignancy (SM). It is a rare phenomenon with poorly understood pathogenesis. SMs are mostly associated with teratomas and are mainly observed in late relapsing cases. There are no consensus guidelines on the management of SMs; however, surgery is considered to be the mainstay of treatment. Prognosis is variable depending on the time of diagnosis, site of relapse, and type of histology. Here, we present a case of a 44-year-old male with a history of mixed GCT stage IIA, initially managed with right radical orchiectomy, who developed a relapse of GCT 10 years later with an SM of adenocarcinoma subtype.

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Section: Discussionmentioning

confidence: 99%

“…The role of radiation in this setting is not well defined either. Therefore, surgical resection of the primary or metastatic site, when resectable, is currently believed to be the mainstay of treatment for SMs to prolong survival [ 10 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Germ Cell Tumor With Somatic-Type Malignancy: A Case Report and Review of the Literature

Cheema¹,

Siddiqui²,

Kamran³

2022

Cureus

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Spectrum of Somatic Malignancy in Testicular Germ Cell Tumors—A Histopathological Review of 25 Cases with Clinical Outcome

Subramanian,

Arora,

Pal

et al. 2024

Indian J Med Paediatr Oncol

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Introduction Germ cell tumors (GCTs) are the commonest testicular malignancy in young males. These tumors are highly chemoresponsive, however become resistant to conventional therapy when a somatic-type malignancy (SM) develops, which happens in ∼3 to 6% of the cases. Methods We reviewed the histologic profile of all cases of testicular/retroperitoneal GCT with SM, diagnosed over a period of 12 years in our institute. Correlation of histologic profile with clinical outcome was done wherever feasible. Results A total of 25 cases of testicular/retroperitoneal GCT with SM were identified for review. The histological spectrum of SMs included carcinoma (n = 9), sarcoma (n = 9), embryonic-type neuroectodermal tumor (ENET) (n = 4), and other rare histological types (n = 3). SMs were frequently seen at the resected metastatic sites (n = 13) and in postchemotherapy setting (n = 12); 14 cases had concurrent GCT and SM at the time of diagnosis/initial resection and 9 cases presented as late relapses (more than 2 years after initial presentation). Four patients were treated with metastasectomy and lymph node dissection, six patients were treated with combined resection and chemotherapy, and nine patients were treated with only adjuvant chemotherapy. The patients with SM confined to testis and those treated with multimodality approach had relatively better outcome. Conclusion GCTs with SM are a highly heterogeneous group of tumors with varying histologic types and management strategies. Strict adherence to histological diagnostic criteria, differentiating these tumors from close mimics such as glandular and sarcomatoid yolk sac tumors, teratomatous overgrowth, and a new second primary somatic tumor are important due to implications in management and prognosis.

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Two cases of somatic-type malignancy as a very late relapse of testicular cancer successfully managed by surgical resection

Cited by 2 publications

References 10 publications

Germ Cell Tumor With Somatic-Type Malignancy: A Case Report and Review of the Literature

Germ Cell Tumor With Somatic-Type Malignancy: A Case Report and Review of the Literature

Spectrum of Somatic Malignancy in Testicular Germ Cell Tumors—A Histopathological Review of 25 Cases with Clinical Outcome

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