Two‐chiral component microemulsion EKC – chiral surfactant and chiral oil. Part 2: Diethyl tartrate

Kahle, Kimberly A.; Foley, Joe P.

doi:10.1002/elps.200600747

Cited by 24 publications

(21 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One noteworthy improvement in resolution was for pseudoephedrine, which dramatically increased between 1.0 Â and 1.5 Â phase ratio compositions. Previous studies indicated that in some cases, two chiral component systems would fare better in efficiencies than those systems with one chiral component [11]. The aggregates containing 1.65% racemic 2-hexanol generally had lower efficiencies as compared with similar systems with S-2-hexanol.…”

Section: Resultsmentioning

confidence: 88%

The effect of co‐surfactant‐modified micelles on chiral separations in EKC

2009

Self Cite

View full text Add to dashboard Cite

The use of chiral pseudostationary phases in EKC provides high efficiencies and excellent resolution for enantiomeric separations. The chiral pseudostationary phases of interest in this study are alcohol-modified ("swollen") micelles, in which a co-surfactant (medium chain-length alcohol) is added with the surfactant. In this study, the chiral surfactant, dodecoxycarbonylvaline (DDCV), along with the co-surfactant, 2-hexanol, has been prepared as swollen micelle in order to investigate the chiral separation of enantiomeric pairs. Three sets of experiments were investigated in which swollen micelle systems contained: chiral surfactant and racemic co-surfactant; chiral surfactant and chiral co-surfactant; and phase ratio increases, in which both chiral surfactant and chiral co-surfactant were employed. In the first two sets of experiments, co-surfactant concentration was held constant and the surfactant concentration was increased. In the third set of experiments, both surfactant and chiral surfactant concentrations were increased proportionally. The chromatographic figures of merit for each enantiomeric pair were investigated and compared with various chiral aggregate systems. In swollen micelle compositions using constant racemic 2-hexanol concentration, when DDCV concentration increased, enantioselectivity and resolution increased; whereas, efficiency remained constant for most of the test compounds. Compositions using constant S-2-hexanol concentration reached a maximum in all chromatographic figures of merit when DDCV concentration was increased from 2 to 3%. An increase in both surfactant and co-surfactant concentrations led to noisy baselines and chiral aggregates that were generally unstable in solution.

show abstract

Section: Resultsmentioning

confidence: 88%

The effect of co‐surfactant‐modified micelles on chiral separations in EKC

2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…the chiral surfactant R-and S-dodecoxycarbonylvaline (DDCV) [11]. Kahle and Foley have completed extensive studies involving the effects of single, dual and triple chiral component ME systems [11,[54][55][56][57]. A summary of their findings are covered in previous reviews [1,57].…”

Section: Advances In Chiral Separations Utilising Meekcmentioning

confidence: 97%

“…In previous studies by Kahle and Foley [11,[54][55][56]58] it was suggested that the chiral surfactant (R-and S-DDCV) may have contained impurities, which would have impacted on the enantioselectivity, resolution, efficiency and migration of enantiomeric ephedrine compounds. Recently, Kojtari and Foley [59] investigated the purity of R-and S-DDCV and its impact on the enantioseparation of chiral ephedrine and pseudoephedrine.…”

Section: Effect Of Me Component Purity On Chiral Separationmentioning

confidence: 99%

Advances in the theory and application of MEEKC

et al. 2010

View full text Add to dashboard Cite

MEEKC is an electrodriven separation technique, which utilises the unique properties of a microemulsion (ME) as a background electrolyte to achieve separation of a diverse range of solutes. MEs are composed of nanometre-sized oil droplets suspended in aqueous buffer, which is commonly referred to as an oil-in-water ME. The droplets are stabilised by the presence of a surfactant and co-surfactant. The use of water-in-oil MEs in MEEKC has also been investigated. This review details the advances in MEEKC-based separations from the period 2008 to 2009. Areas covered include online sample concentration, suppressed electroosmosis MEEKC, chiral separation, MEEKC-MS, and structure-migration relationships. The review also includes a fundamental introduction to MEEKC, along with the presentation of recent applications.

show abstract

“…Atenolol enantiomers were partially separated using diethyl tartrate microemulsions. With a three-chiral component microemulsion, an increase in enantioresolution of MT (Rs 1.59, 1.85, 1.95, with one, two, three-chiral component, respectively) was achieved while a decrease in efficiency was observed for atenolol (N 126100, 103400, 87400, with one, two, three-chiral component, respectively) [111][112][113].…”

Section: Mekc and Meekcmentioning

confidence: 99%

Advances in the enantioseparation of β‐blocker drugs by capillary electromigration techniques

Aturki¹,

D’Orazio²,

Rocco³

et al. 2011

Electrophoresis

View full text Add to dashboard Cite

β-Blocker drugs or β-adrenergic blocking agents are an important class of drugs, prescribed with great frequency. They are used for various diseases, particularly for the treatment of cardiac arrhythmias, cardioprotection after myocardial infarction (heart attack), and hypertension. Almost all β-blocker drugs possess one or more stereogenic centers; however; only some of them are administered as single enantiomers. Since both enantiomers can differ in their pharmacological and toxicological properties, enantioselective analytical methods are required not only for pharmacodynamic and pharmacokinetic studies but also for quality control of pharmaceutical preparations with the determination of enantiomeric purity. In addition to the chromatographic tools, in recent years, capillary electromigration techniques (CE, CEC, and MEKC) have been widely used for enantioselective purposes employing a variety of chiral selectors, e.g. CDs, polysaccharides, macrocyclic antibiotics, proteins, chiral ion-paring agents, etc. The high separation efficiency, rapid analysi,s and low consumption of reagents of electromigration methods make them a very attractive alternative to the conventional chromatographic methods. In this review, the development and applications of electrodriven methods for the enantioseparation of β-blocker drugs are reported. The papers concerning this topic, published from January 2000 until December 2010, are summarised here. Particular attention is given to the coupling of chiral CE and CEC methods to MS, as this detector provides high sensitivity and selectivity.

show abstract

Two‐chiral component microemulsion EKC – chiral surfactant and chiral oil. Part 2: Diethyl tartrate

Cited by 24 publications

References 66 publications

The effect of co‐surfactant‐modified micelles on chiral separations in EKC

The effect of co‐surfactant‐modified micelles on chiral separations in EKC

Advances in the theory and application of MEEKC

Advances in the enantioseparation of β‐blocker drugs by capillary electromigration techniques

Contact Info

Product

Resources

About