Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls

Abstract

Recent studies have focused on the associations of catalase polymorphisms with various types of cancer, including cervical and prostate cancers. However, the results were inconsistent. To obtain a more reliable conclusion, we evaluated the relationship between the two common catalase gene polymorphisms (rs1001179 and rs794316) and cancer risk by a meta-analysis. Our meta-analysis included 37 published studies involving 14,942 cancer patients and 43,285 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the cancer risk. The results demonstrated that the rs1001179 polymorphism was associated with an increased cancer risk in the recessive and homozygote models (TT vs. CC: OR = 1.19, P = 0.01; TT vs. CT+CC: OR = 1.19, P <0.001). Furthermore, stratified analyses revealed a significant association between the rs1001179 polymorphism and prostate cancer in all models except the homozygote comparison. An association of the rs794316 polymorphism with cancer risk was detected in two genetic models (TT vs. AA: OR = 1.34, 95% CI = 1.03–1.74, P <0.001; TT vs. AT+AA: OR = 1.39, 95% CI = 1.09–1.77, P = 0.01). Additional well-designed studies with large samples should be performed to validate our results.

Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

“…In a case-control study, we observed a greater risk for developing ICC associated with the homozygote genotype TT of CAT polymorphism C-262 T polymorphism of the CAT gene (OR = 3.03, 95% CI 1.46-6.29, P = 0.003) [31]. Similarly to other cancers types, the T variant of this polymorphism is associated to a decreased enzyme activity, generating high levels of ROS [32][33][34]. The interaction of CC genotype of p22phox polymorphism and the TT genotype of CAT leads to a higher risk for ICC (OR = 3.95, 95% CI 1.07-14.52, P = 0.032) [31].…”

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

“…A previous study in the Hungarian population has reported the relationship between catalase gene (CAT ) polymorphism (C-262T, rs1001179) and HDL-C levels (Goth et al, 2012); T2DM patients with TT had significantly lower HDL-C level than CC carriers. The present study, however, did not explore this SNP in the Thai population because rare minor allele frequency (4%) has been reported in the Asian population (Liu et al, 2016).…”

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

“…These molecules can act as pro-tumorigenic signals that promote, among others, abnormal cell growth, migration, resistance to apoptosis, adaptations to hypoxia, and genetic instability [159]. Interestingly, low CAT activity has been associated with an increased risk factor for many different cancers, including skin cancer [160], colorectal cancer [161], breast cancer [162], invasive cervical cancer [163], ovarian cancer [164], and prostate cancer [165,166,167]. On the other hand, overexpression of CAT in MCF-7 mammary cancer cells has been reported to result in a less aggressive phenotype and an altered response to chemotherapy [118].…”