Two-Dimensional Cs<sub>2</sub>AgBiBr<sub>6</sub>-Based Biosensor for Selective and Sensitive Detection of Cardiac Biomarker Troponin I

Lu, Yin-Cheng; Darius, Evan; Lien, Mei-Chin; Yeh, I-Hsiu; Shi, Hui-Fang; Huang, Yung-Hsin; Chen, Chien-Hung; Chen, Hung-Wen; Su, Ching-Yuan; Hsu, Ru-Yin; Liu, Keng-Ku

doi:10.1021/acsanm.3c04385

Cited by 4 publications

(2 citation statements)

References 38 publications

(72 reference statements)

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“…Using this very concept, PEF has been very effectively used in the past decade as a tool for sensing different analytes, biomolecules, nucleic acids, etc. ( Gao et al, 2023 ; Lu et al, 2023 ; Rippa et al, 2024 ). The present technique of specific RNA quantification involves complementary base pairing between a target RNA and the nucleic acid probe.…”

Section: Examples Of Fluorescence Enhancementmentioning

confidence: 99%

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Dasgupta,

Ray

2024

Front. Chem.

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Fluorescence spectroscopy serves as an ultrasensitive sophisticated tool where background noises which serve as a major impediment to the detection of the desired signals can be safely avoided for detections down to the single-molecule levels. One such way of bypassing background noise is plasmon-enhanced fluorescence (PEF), where the interactions of fluorophores at the surface of metals or plasmonic nanoparticles are probed. The underlying condition is a significant spectral overlap between the localized surface plasmon resonance (LSPR) of the nanoparticle and the absorption or emission spectra of the fluorophore. The rationale being the coupling of the excited state of the fluorophore with the localized surface plasmon leads to an augmented emission, owing to local field enhancement. It is manifested in enhanced quantum yields concurrent with a decrease in fluorescence lifetimes, owing to an increase in radiative rate constants. This improvement in detection provided by PEF allows a significant scope of expansion in the domain of weakly emitting fluorophores which otherwise would have remained unperceivable. The concept of coupling of weak emitters with plasmons can bypass the problems of photobleaching, opening up avenues of imaging with significantly higher sensitivity and improved resolution. Furthermore, amplification of the emission signal by the coupling of free electrons of the metal nanoparticles with the electrons of the fluorophore provides ample opportunities for achieving lower detection limits that are involved in biological imaging and molecular sensing. One avenue that has attracted significant attraction in the last few years is the fast, label-free detection of bio-analytes under physiological conditions using plasmonic nanoparticles for point-of-care analysis. This review focusses on the applications of plasmonic nanomaterials in the field of biosensing, imaging with a brief introduction on the different aspects of LSPR and fabrication techniques.

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Section: Examples Of Fluorescence Enhancementmentioning

confidence: 99%

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Dasgupta,

Ray

2024

Front. Chem.

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“…Plasmonic silver nanomaterials have been also demonstrated for the detection applications because of their superior optical characteristic [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Based on strong surface plasmon resonance, silver nanomaterials have been extensively utilized for the detections of elements, molecules, proteins, and bacteria [ 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Au@Ag Core–Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria

Husain,

Mutalik,

Yougbaré

et al. 2024

Nanomaterials

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Plasmonic metal nanomaterials have been extensively investigated for their utilizations in biomedical sensing and treatment. In this study, plasmonic Au@Ag core–shell nanoisland films (Au@AgNIFs) were successfully grown onto a glass substrate using a seed-mediated growth procedure. The nanostructure of the Au@AgNIFs was confirmed through scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy (AFM). The UV-Vis spectra of the Au@AgNIFs exhibited a broad absorption in the visible range from 300 to 800 nm because of the surface plasmon absorption. Under simulated sunlight exposure, the temperature of optimal Au@AgNIF was increased to be 66.9 °C to meet the requirement for photothermal bacterial eradication. Furthermore, the Au@AgNIFs demonstrated a consistent photothermal effect during the cyclic on/off exposure to light. For photothermal therapy, the Au@AgNIFs revealed superior efficiency in the photothermal eradication of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). With their unique nanoisland nanostructure, the Au@AgNIFs exhibited excellent growth efficiency of bacteria in comparison with that of the bare glass substrate. The Au@AgNIFs were also validated as a surface-enhanced Raman scattering (SERS) substrate to amplify the Raman signals of E. coli and S. aureus. By integrating photothermal therapy and SERS detection, the Au@AgNIFs were revealed to be a potential platform for bacterial theranostics.

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Copper(II)-Tannic Acid@Cu with In Situ Grown Gold Nanoparticles as a Bifunctional Matrix for Facile Construction of Label-Free and Ultrasensitive Electrochemical cTnI Immunosensor

Liu,

Yang,

et al. 2024

ACS Appl. Bio Mater.

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Sensitive detection of cardiac troponin I (cTnI) is of great significance in the diagnosis of a fatal acute myocardial infarction. A redox-active nanocomposite of copper(II)-tannic acid@Cu (CuTA@Cu) was herein prepared on the surface of a glassy carbon electrode by electrochemical deposition of metallic copper combined with a metal stripping strategy. Then, HAuCl 4 was in situ reduced to gold nanoparticles (AuNPs) by strong reductive catechol groups in the TA ligand. The AuNPs/CuTA@ Cu composite was further utilized as a bifunctional matrix for the immobilization of the cTnI antibody (anti-cTnI), producing an electrochemical immunosensor. Electrochemical tests show that the immunoreaction between anti-cTnI and target cTnI can cause a significant reduction of the electrochemical signal of CuTA@Cu. It can be attributed to the insulating characteristic of the immunocomplex and its barrier effect to the electrolyte ion diffusion. From the signal changes of CuTA@Cu, cTnI can be analyzed in a wide range from 10 fg mL −1 to 10 ng mL −1 , with an ultralow detection limit of 0.65 fg mL −1 . The spiked recovery assays show that the immunosensor is reliable for cTnI determination in human serum samples, demonstrating its promising application in the early clinical diagnosis of myocardial infarction.

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Two-Dimensional Cs₂AgBiBr₆-Based Biosensor for Selective and Sensitive Detection of Cardiac Biomarker Troponin I

Cited by 4 publications

References 38 publications

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Plasmonic Au@Ag Core–Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria

Copper(II)-Tannic Acid@Cu with In Situ Grown Gold Nanoparticles as a Bifunctional Matrix for Facile Construction of Label-Free and Ultrasensitive Electrochemical cTnI Immunosensor

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Two-Dimensional Cs2AgBiBr6-Based Biosensor for Selective and Sensitive Detection of Cardiac Biomarker Troponin I

Cited by 4 publications

References 38 publications

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Plasmon-enhanced fluorescence for biophotonics and bio-analytical applications

Plasmonic Au@Ag Core–Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria

Copper(II)-Tannic Acid@Cu with In Situ Grown Gold Nanoparticles as a Bifunctional Matrix for Facile Construction of Label-Free and Ultrasensitive Electrochemical cTnI Immunosensor

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Two-Dimensional Cs₂AgBiBr₆-Based Biosensor for Selective and Sensitive Detection of Cardiac Biomarker Troponin I