Two-dimensional nanomaterials-added dynamism in 3D printing and bioprinting of biomedical platforms: Unique opportunities and challenges

Gaihre, Bipin; Potes, Maria D. Astudillo; Serdiuk, Vitalii; Tilton, Maryam; Liu, Xifeng; Lu, Lichun

doi:10.1016/j.biomaterials.2022.121507

Cited by 22 publications

(12 citation statements)

References 224 publications

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“…Depending on the biological requirements of the surrounding tissue, various biomaterials or biomolecules may be applied to 3D-printed scaffolds. These include bioceramics (hydroxyapatite, tricalcium phosphate), nanomaterials (metal–organic frameworks, covalent organic framework), cell-affinity biopolymers (chitosan, collagen), RGD (Arg-Gly-Asp) peptides, anti-infection drugs, and growth factors (BMP-2, VEGF) [ [67] , [68] , [69] ].…”

Section: Discussionmentioning

confidence: 99%

3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

Liu

Gaihre

Park

et al. 2023

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

Liu

Gaihre

Park

et al. 2023

Bioactive Materials

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“…Extrusion printing involves inks' extrusion through one or multiple nozzles to produce 3D structures. [192,193] The extrusion strategies are sorted into coagulation bath printing, free-form reversible embedding, direct ink writing, and coaxial printing. [194,195] The advantages of this technique rely on the possibility to print hydrogels with different viscosities and the use of high cell densities.…”

Section: Moldingmentioning

confidence: 99%

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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Cartilage degeneration is among the fundamental reasons behind disability and pain across the globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none have shown acceptable outcomes in the long run. In this regard, the convergence of tissue engineering and microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives to current treatments and traditional constructs used in tissue engineering applications. Herein, the current developments involving microfluidic hydrogel‐based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors, as well as cartilage‐related organ‐on‐chips are reviewed. Thereafter, cartilage anatomy and types of damages, and present treatment options are briefly overviewed. Various hydrogels are introduced, and the advantages of microfluidic hydrogel‐based scaffolds over traditional hydrogels are thoroughly discussed. Furthermore, available technologies for fabricating microfluidic hydrogel‐based scaffolds and microfluidic chips are presented. The preclinical and clinical applications of microfluidic hydrogel‐based scaffolds in cartilage regeneration and the development of cartilage‐related microfluidic chips over time are further explained. The current developments, recent key challenges, and attractive prospects that should be considered so as to develop microfluidic systems in cartilage repair are highlighted.

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“…In contrast to the other shown categories, the 2D ➔ 3D fabrication using click chemistry is not significantly mentioned in the literature. Moreover, several comprehensive reviews such as [ 59 , 60 , 61 , 62 ] in the field did not mention click chemistry at all as a possible method for such a purpose. However, a few examples found in the literature are reviewed in this section.…”

Section: Hierarchical Structures and Click Chemistrymentioning

confidence: 99%

Click Chemistry: A Promising Tool for Building Hierarchical Structures

Badria

2022

Polymers

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The hierarchical structures are utilized at different levels in nature. Moreover, a wide spectrum of nature’s properties (e.g., mechanical, physical and biological properties) has been attributed to this hierarchy. Different reviews have been published to cover the use of click chemistry in building hierarchical structures. However, each one of those reviews focused on a narrow area on this topic, i.e., specific chemical reaction, such as in thiol-ene chemistry, or a specific molecule or compound such as polyhedral oligomeric silsesquioxane, or a certain range of hierarchical structures between the nano to micro range, e.g., nanocrystals. In this review, a frame to connect the dots between the different published works has been demonstrated. This article will not attempt to give an exhaustive review of all the published work in the field, instead the potential of click chemistry to build hierarchical structures of different levels using building blocks of different length scales has been shown through two main approaches. The first is a one-step direct formation of 3D micro/macrometer dimensions structures from Pico dimensions structures (molecules, monomers, etc.). The second approach includes several steps Pico ➔ 0D nano ➔ 1D nano ➔ 2D nano ➔ 3D nano/micro/macro dimensions structures. Another purpose of this review article is to connect between (a) the atomic theory, which covers the atoms and molecules in the picometer dimensions (picoscopic chemistry set); (b) “nano-periodic system” model, which covers different nanobuilding blocks in the nanometers range such as nanoparticles, dendrimers, buckyball, etc. which was developed by Tomalia; and (c) the micro/macrometer dimensions level.

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Two-dimensional nanomaterials-added dynamism in 3D printing and bioprinting of biomedical platforms: Unique opportunities and challenges

Cited by 22 publications

References 224 publications

3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

Click Chemistry: A Promising Tool for Building Hierarchical Structures

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