Two dimensional α-MoO 3-x nanoflakes as bare eye probe for hydrogen peroxide in biological fluids

Sharma, Amit Kumar; Pandey, Sunil; Sharma, Krishna Hari; Nerthigan, Yowan; Khan, M. Shahnawaz; Hang, Da-Ren; Wu, Hui‐Fen

doi:10.1016/j.aca.2018.01.057

Cited by 30 publications

(11 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So far, various techniques for H 2 O 2 determination have been explored, such as fluorometry [ 3 , 4 ], cellular imaging [ 5 ], electrochemistry [ 6 , 7 ], and the colorimetric method [ 8 , 9 ]. Among these approaches, the colorimetric method has drawn a lot of attention due to its convenient operation, visibility, facile miniaturization, and low cost [ 10 , 11 ]. In this respect, natural enzymes were extensively used for the detection of H 2 O 2 due to its catalysis capability under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

et al. 2020

Self Cite

View full text Add to dashboard Cite

We report the facile and economic preparation of two-dimensional (2D) and 0D MoSe2 nanostructures based on systematic and non-toxic top-down strategies. We demonstrate the intrinsic peroxidase-like activity of these MoSe2 nanostructures. The catalytic processes begin with facilitated decomposition of H2O2 by using MoSe2 nanostructures as peroxidase mimetics. In turn, a large amount of generated radicals oxidizes 3,3,5,5-tetramethylbenzidine (TMB) to produce a visible color reaction. The enzymatic kinetics of our MoSe2 nanostructures complies with typical Michaelis–Menten theory. Catalytic kinetics study reveals a ping–pong mechanism. Moreover, the primary radical responsible for the oxidation of TMB was identified to be Ȯ2− by active species-trapping experiments. Based on the peroxidase mimicking property, we developed a new colorimetric method for H2O2 detection by using 2D and 0D MoSe2 nanostructures. It is shown that the colorimetric sensing capability of our MoSe2 catalysts is comparable to other 2D materials-based colorimetric platforms. For instance, the linear range of H2O2 detection is between 10 and 250 μM by using 2D functionalized MoSe2 nanosheets as an artificial enzyme. Our work develops a systematic approach to use 2D materials to construct novel enzyme-free mimetic for a visual assay of H2O2, which has promising prospects in medical diagnosis and food security monitoring.

show abstract

Section: Introductionmentioning

confidence: 99%

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides, it is known that over 80% of biosensor industry research is related to glucose sensors. Therefore, the development of a facile, low-priced, and accurate sensor for H 2 O 2 and glucose continue to receive tremendous research effort [17, 18].…”

Section: Introductionmentioning

confidence: 99%

Facile Bottom-up Preparation of WS2-Based Water-Soluble Quantum Dots as Luminescent Probes for Hydrogen Peroxide and Glucose

et al. 2019

Self Cite

View full text Add to dashboard Cite

Photoluminescent zero-dimensional (0D) quantum dots (QDs) derived from transition metal dichalcogenides, particularly molybdenum disulfide, are presently in the spotlight for their advantageous characteristics for optoelectronics, imaging, and sensors. Nevertheless, up to now, little work has been done to synthesize and explore photoluminescent 0D WS 2 QDs, especially by a bottom-up strategy without using usual toxic organic solvents. In this work, we report a facile bottom-up strategy to synthesize high-quality water-soluble tungsten disulfide (WS 2 ) QDs through hydrothermal reaction by using sodium tungstate dihydrate and l -cysteine as W and S sources. Besides, hybrid carbon quantum dots/WS 2 QDs were further prepared based on this method. Physicochemical and structural analysis of QD hybrid indicated that the graphitic carbon quantum dots with diameters about 5 nm were held onto WS 2 QDs via electrostatic attraction forces. The resultant QDs show good water solubility and stable photoluminescence (PL). The excitation-dependent PL can be attributed to the polydispersity of the synthesized QDs. We found that the PL was stable under continuous irradiation of UV light but can be quenched in the presence of hydrogen peroxide (H 2 O 2 ). The obtained WS 2 -based QDs were thus adopted as an electrodeless luminescent probe for H 2 O 2 and for enzymatic sensing of glucose. The hybrid QDs were shown to have a more sensitive LOD in the case of glucose sensing. The Raman study implied that H 2 O 2 causes the partial oxidation of QDs, which may lead to oxidation-induced quenching. Overall, the presented strategy provides a general guideline for facile and low-cost synthesis of other water-soluble layered material QDs and relevant hybrids in large quantity. These WS 2 -based high-quality water-soluble QDs should be promising for a wide range of applications in optoelectronics, environmental monitoring, medical imaging, and photocatalysis. Electronic supplementary material The online version of this article (10.1186/s11671-019-3109-5) contains supplementary material, which is available to authorized users.

show abstract

“…The linear regression plotted for F/F 0 relative intensity was calculated to be 0.9814 (the error bars indicate the standard deviation calculated up to three repetitions of the experiment) (Figure 7B). This limit of detection was calculated to be 1.17 nM which is significantly sensitive in comparison to previous reports 45 (Figure S10). Similar set of experiment was performed to observe the sensitivity of CME solution to detect H 2 O 2 in biological fluids (urine) shown in Figure 8.…”

Section: ■ Results and Discussionmentioning

confidence: 52%

“…It is known that an altered level of H 2 O 2 in the human body is a vital marker for several biological changes such as aging, tissue or membrane damage, nuclear material mutation, thereby leading to cancer, neurological disorders, and oxidative stress . In addition to the previous reports on sensing low levels of H 2 O 2 , , there is further room to develop facile and ultrasensitive techniques for detecting oxidative stress in biological samples. The CME perovskites were found to exhibit an enhanced fluorescence signal at low concentrations of H 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%

Ce_1.0Mo_0.15Eu_0.05O_x Aqueous Perovskites for Stable Near-Infrared Emission and Their Sensitivity toward Hydrogen Peroxide

Sharma

Pandey

et al. 2020

ACS Sustainable Chem. Eng.

Self Cite

View full text Add to dashboard Cite

We report a solvent free method to synthesize red fluorescent perovskites from oxide salts of cerium, molybdenum, and europium (CME perovskites). A combination of dry and wet grinding followed by annealing and calcination results in a crystalline and highly ordered structures of CME perovskites. The particle size obtained was surprisingly small (<100 nm) with aqueous dispersity and intense red fluorescence in the near-infrared (NIR) regime. The quantum yield of the CME perovskites was calculated to be 9.71%. We found that the metal oxide bond can be altered using hydrogen peroxide (H2O2) resulting in an enhanced fluorescence signal. Owing to its high sensitivity to low concentration levels of H2O2, the perovskites are utilized to detect hydrogen peroxide up to 1.17 nM in aqueous solution and 1.62 nM in a biological fluid (urine).

show abstract

Two dimensional α-MoO 3-x nanoflakes as bare eye probe for hydrogen peroxide in biological fluids

Cited by 30 publications

References 67 publications

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

Facile Bottom-up Preparation of WS2-Based Water-Soluble Quantum Dots as Luminescent Probes for Hydrogen Peroxide and Glucose

Ce_1.0Mo_0.15Eu_0.05O_x Aqueous Perovskites for Stable Near-Infrared Emission and Their Sensitivity toward Hydrogen Peroxide

Contact Info

Product

Resources

About

Two dimensional α-MoO 3-x nanoflakes as bare eye probe for hydrogen peroxide in biological fluids

Cited by 30 publications

References 67 publications

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

2D CTAB-MoSe2 Nanosheets and 0D MoSe2 Quantum Dots: Facile Top-Down Preparations and Their Peroxidase-Like Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide

Facile Bottom-up Preparation of WS2-Based Water-Soluble Quantum Dots as Luminescent Probes for Hydrogen Peroxide and Glucose

Ce1.0Mo0.15Eu0.05Ox Aqueous Perovskites for Stable Near-Infrared Emission and Their Sensitivity toward Hydrogen Peroxide

Contact Info

Product

Resources

About

Ce_1.0Mo_0.15Eu_0.05O_x Aqueous Perovskites for Stable Near-Infrared Emission and Their Sensitivity toward Hydrogen Peroxide