Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

Lecuit, Thomas; Brook, William J.; Ng, Medard; Calleja, M.; Sun, Henry; Cohen, Stephen M.

doi:10.1038/381387a0

Cited by 607 publications

(451 citation statements)

References 41 publications

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“…Second, activin and TGF-␤1 are able to signal across layers of cells lacking receptors (Gurdon et al, 1994), indicating that these factors were not inducers of other morphogens and, therefore, were acting directly on cells at some distance from their source. Elegant genetic studies using receptorless cells had previously led to similar conclusions for Dpp (BMP4) and Wingless (Wnt) signaling in Drosophila (Nellen et al, 1996;Zecca et al, 1996;Lecuit et al, 1996). A weakness of the Xenopus studies is that they relied on the use of ligands and receptors (activin and TGF-␤1 and a TGF-␤ receptor) that are not expressed in the embryo.…”

Section: Establishment Of Morphogen Gradients Part I: Evidence For Dmentioning

confidence: 99%

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

Green

2002

Developmental Dynamics

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The idea of morphogen gradients has long been an important one in developmental biology. Studies with amphibians and with Xenopus in particular have made significant contributions to demonstrating the existence, identity, and mechanisms of action of morphogens. Mesoderm induction and patterning by activin, nodals, bone morphogenetic proteins, and fibroblast growth factors have been analyzed thoroughly and reveal recurrent and combinatorial roles for these protein growth factor morphogens and their antagonists. The dynamics of nodal-type signaling and the intersection of VegT and ␤-catenin intracellular gradients reveal detailed steps in early long-range patterning. Interpretation of gradients requires sophisticated mechanisms for sharpening thresholds, and the activin-Xbra-Gsc system provides an example of this. The understanding of growth factor signal transduction has elucidated growth factor morphogen action and provided tools for dissecting their direct longrange action and distribution. The physical mechanisms of morphogen gradient establishment are the focus of new interest at both the experimental and theoretical level. General themes and emerging trends in morphogen gradient studies are discussed.

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Section: Establishment Of Morphogen Gradients Part I: Evidence For Dmentioning

confidence: 99%

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

Green

2002

Developmental Dynamics

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“…Both Spalt (Lecuit et al 1996;Nellen et al 1996) and the PRDII-BF1 family member Schnurri (Arora et al 1995;Grieder et al 1995) have been shown to be targets of signaling by the TGF-f3-1ike protein Decapentaplegic. The sequence similarities among SEM-4, Spalt, and PRDII-BF1 family members raise the possibility that SEM-4 activity might also be controlled by a signal transduction pathway.…”

Section: V5paapp Cell Death Pnp Hypodermal Cellsmentioning

confidence: 99%

The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.

Basson¹,

Horvitz²

1996

Genes Dev.

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The large number of different types of neurons in both vertebrate and invertebrate nervous systems raises the question of how the development of a particular neuronal cell type is specified. To pursue this question, Desai et al. (1988;Desai and Horvitz 1989) initiated a genetic analysis of the HSN serotonergic motor neurons in Caenorhabditis elegans. This analysis identified genes that are required for a number of distinct aspects of HSN development and placed these genes in a pathway of gene action. Some of these genes encode types of proteins that have been shown to control neuronal development in other organisms. Examples of such genes are egl-5, which encodes a homeo domain protein (Wang et al. 1993); unc-6, which encodes a member of the netrin family {Serafini et al. 1994); unc-33, which encodes a protein that is related to CRMP-62, a chick collapsin response mediator protein (Goshima et al. 1995); and unc-86, which encodes a POU homeo domain protein (Finney and Ruvkun 1990). This correlation between the types of proteins that control HSN development and the types of proteins that control neuronal development in other organisms suggests that study of HSN development will reveal general principles of how neuronal cell type is specified.~Corresponding author.The POU gene unc-86 is required for the normal pattern of HSN axonal outgrowth, normal HSN nuclear morphology, and HSN serotonin expression (Desai et al. 1988). POU homeo domain proteins have been shown to be required for neuronal development in both Drosophila (Bhat et al. 1995;Yeo et al. 1995) and mammals (for review, see Sharp and Morgan 1996). Mutation of the C. elegans gene sere-4 (sex muscle defective) causes the same spectrum of defects in HSN development as that caused by mutation of unc-86 (Desai et al. 1988). Because POU homeo domain proteins seem likely to play an evolutionarily conserved role in neuronal development, we are interested in determining how the SEM-4 and UNC-86 proteins interact in controlling HSN development. To understand how sem-4 functions in HSN development as well as in the development of other cell types, we have performed a genetic and molecular analysis of sere-4.

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“…Dpp acts as a long-range morphogen and regulates gene expression in imaginal discs in a concentration-dependent manner (Lecuit et al, 1996;Nellen et al, 1996). In response to Dpp signaling, an activated form of the Smad transcription factor, Mothers against dpp (Mad), is generated.…”

Section: Introductionmentioning

confidence: 99%

Opposing inputs by Hedgehog and Brinker define a stripe ofhairyexpression in theDrosophilaleg imaginal disc

et al. 2004

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Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

Cited by 607 publications

References 41 publications

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.

Opposing inputs by Hedgehog and Brinker define a stripe ofhairyexpression in theDrosophilaleg imaginal disc

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